Effect of acetylsalicylic acid on nuclear factor-kappaB activation and on late preconditioning against infarction in the myocardium

Nuclear factor-kappaB (NF-kappaB) plays an essential role in the intracellular signal transduction of the second window of protection (SWOP). Acetylsalicylic acid (ASA) blocks NF-kappaB-dependent gene activation in leukocytes and endothelial cells through preventing phosphorylation and subsequent de...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 2005-09, Vol.46 (3), p.295-301
Hauptverfasser:	Jancso, Gabor, Cserepes, Barbara, Gasz, Balázs, Benko, Laszlo, Ferencz, Andrea, Borsiczky, Balazs, Lantos, Janos, Dureja, Anjali, Kiss, Katalin, Szeberényi, Jozsef, Roth, Elizabeth
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arrhythmias, Cardiac - physiopathology Aspirin - pharmacology Biotransformation - drug effects Cyclooxygenase Inhibitors - pharmacology Electrophoretic Mobility Shift Assay Ischemic Preconditioning, Myocardial Myocardial Infarction - pathology Myocardial Infarction - prevention & control Myocardium - pathology NF-kappa B - metabolism Rabbits Signal Transduction - drug effects Time Factors
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