Low serum LDL cholesterol levels and the risk of fever, sepsis, and malignancy
Lipid lowering therapy of serum LDL cholesterol (LDL) has proved beneficial in reducing cardiovascular morbidity and mortality. Lately the recommended target LDL level in very high risk patients was reduced to
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| Veröffentlicht in: | Annals of clinical and laboratory science 2007, Vol.37 (4), p.343-348 |
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| container_title | Annals of clinical and laboratory science |
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| creator | Shor, Renana Wainstein, Julio Oz, David Boaz, Mona Matas, Zipora Fux, Asora Halabe, Aaron |
| description | Lipid lowering therapy of serum LDL cholesterol (LDL) has proved beneficial in reducing cardiovascular morbidity and mortality. Lately the recommended target LDL level in very high risk patients was reduced to |
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Lately the recommended target LDL level in very high risk patients was reduced to <70 mg/dl, raising the question of what the price of such a low level will be. To elucidate this concern, we investigated the associations of low serum LDL cholesterol levels (< or = 70 mg/dl) and the incidences of fever, sepsis, and malignancy. Retrospective analysis of 203 patients' charts was carried out. Patients were divided into 2 groups: Group 1 (n = 79) had serum LDL levels < or = 70 mg/dl, while Group 2 (n = 124) had levels >70 mg/dl. The first group demonstrated increased odds of hematological cancer by more than 15-fold (OR 15.7, 95% CI 1.78-138.4, p = 0.01). Each 1 mg/dl increase in LDL was associated with a relative reduction of 2.4% in the odds of hematological cancer (OR 0.976, 95% CI 0.956-0.997, p = 0.026). Low LDL levels also increased the odds of fever and sepsis between the groups (OR 5.3, 95% CI 1.8-15.7, p = 0.02). In summary, low serum LDL cholesterol level was associated with increased risks of hematological cancer, fever, and sepsis.</description><identifier>ISSN: 0091-7370</identifier><identifier>PMID: 18000291</identifier><language>eng</language><publisher>United States</publisher><subject>Aged ; Causality ; Cholesterol, LDL - blood ; Female ; Fever - epidemiology ; Fever - etiology ; Hematologic Neoplasms - epidemiology ; Hematologic Neoplasms - etiology ; Humans ; Logistic Models ; Male ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Sepsis - epidemiology ; Sepsis - etiology</subject><ispartof>Annals of clinical and laboratory science, 2007, Vol.37 (4), p.343-348</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18000291$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shor, Renana</creatorcontrib><creatorcontrib>Wainstein, Julio</creatorcontrib><creatorcontrib>Oz, David</creatorcontrib><creatorcontrib>Boaz, Mona</creatorcontrib><creatorcontrib>Matas, Zipora</creatorcontrib><creatorcontrib>Fux, Asora</creatorcontrib><creatorcontrib>Halabe, Aaron</creatorcontrib><title>Low serum LDL cholesterol levels and the risk of fever, sepsis, and malignancy</title><title>Annals of clinical and laboratory science</title><addtitle>Ann Clin Lab Sci</addtitle><description>Lipid lowering therapy of serum LDL cholesterol (LDL) has proved beneficial in reducing cardiovascular morbidity and mortality. Lately the recommended target LDL level in very high risk patients was reduced to <70 mg/dl, raising the question of what the price of such a low level will be. To elucidate this concern, we investigated the associations of low serum LDL cholesterol levels (< or = 70 mg/dl) and the incidences of fever, sepsis, and malignancy. Retrospective analysis of 203 patients' charts was carried out. Patients were divided into 2 groups: Group 1 (n = 79) had serum LDL levels < or = 70 mg/dl, while Group 2 (n = 124) had levels >70 mg/dl. The first group demonstrated increased odds of hematological cancer by more than 15-fold (OR 15.7, 95% CI 1.78-138.4, p = 0.01). Each 1 mg/dl increase in LDL was associated with a relative reduction of 2.4% in the odds of hematological cancer (OR 0.976, 95% CI 0.956-0.997, p = 0.026). Low LDL levels also increased the odds of fever and sepsis between the groups (OR 5.3, 95% CI 1.8-15.7, p = 0.02). In summary, low serum LDL cholesterol level was associated with increased risks of hematological cancer, fever, and sepsis.</description><subject>Aged</subject><subject>Causality</subject><subject>Cholesterol, LDL - blood</subject><subject>Female</subject><subject>Fever - epidemiology</subject><subject>Fever - etiology</subject><subject>Hematologic Neoplasms - epidemiology</subject><subject>Hematologic Neoplasms - etiology</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Sepsis - epidemiology</subject><subject>Sepsis - etiology</subject><issn>0091-7370</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1UMtOxCAUZaFxxtFfMKxcTRMoUGBpxmfS6EbXDS0XW6WlQquZv7fquDo59zxyc47QmhBNM8kkWaHTlN4IyTXn5AStqCI_hK7RYxm-cII497i8LnHTBg9pghg89vAJPmEzWDy1gGOX3nFw2C3nuF0yY-rS9lfuje9eBzM0-zN07IxPcH7ADXq5vXne3Wfl093D7qrM2pzpKVONobKwsm6cYYUAal1RWyqUAW1rK6mWhrvaKbBUc-uEEQq0IkByyyG3bIMu_3rHGD7m5eOq71ID3psBwpyqQgnCBOOL8eJgnOsebDXGrjdxX_0vwL4Bv-xXEg</recordid><startdate>2007</startdate><enddate>2007</enddate><creator>Shor, Renana</creator><creator>Wainstein, Julio</creator><creator>Oz, David</creator><creator>Boaz, Mona</creator><creator>Matas, Zipora</creator><creator>Fux, Asora</creator><creator>Halabe, Aaron</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2007</creationdate><title>Low serum LDL cholesterol levels and the risk of fever, sepsis, and malignancy</title><author>Shor, Renana ; Wainstein, Julio ; Oz, David ; Boaz, Mona ; Matas, Zipora ; Fux, Asora ; Halabe, Aaron</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h239t-8ca176d7bcfa365e1df6bd158ae9dbd7197a4fbf8ed194df5a58e980e02d4e2d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Causality</topic><topic>Cholesterol, LDL - blood</topic><topic>Female</topic><topic>Fever - epidemiology</topic><topic>Fever - etiology</topic><topic>Hematologic Neoplasms - epidemiology</topic><topic>Hematologic Neoplasms - etiology</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Sepsis - epidemiology</topic><topic>Sepsis - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shor, Renana</creatorcontrib><creatorcontrib>Wainstein, Julio</creatorcontrib><creatorcontrib>Oz, David</creatorcontrib><creatorcontrib>Boaz, Mona</creatorcontrib><creatorcontrib>Matas, Zipora</creatorcontrib><creatorcontrib>Fux, Asora</creatorcontrib><creatorcontrib>Halabe, Aaron</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of clinical and laboratory science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shor, Renana</au><au>Wainstein, Julio</au><au>Oz, David</au><au>Boaz, Mona</au><au>Matas, Zipora</au><au>Fux, Asora</au><au>Halabe, Aaron</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low serum LDL cholesterol levels and the risk of fever, sepsis, and malignancy</atitle><jtitle>Annals of clinical and laboratory science</jtitle><addtitle>Ann Clin Lab Sci</addtitle><date>2007</date><risdate>2007</risdate><volume>37</volume><issue>4</issue><spage>343</spage><epage>348</epage><pages>343-348</pages><issn>0091-7370</issn><abstract>Lipid lowering therapy of serum LDL cholesterol (LDL) has proved beneficial in reducing cardiovascular morbidity and mortality. Lately the recommended target LDL level in very high risk patients was reduced to <70 mg/dl, raising the question of what the price of such a low level will be. To elucidate this concern, we investigated the associations of low serum LDL cholesterol levels (< or = 70 mg/dl) and the incidences of fever, sepsis, and malignancy. Retrospective analysis of 203 patients' charts was carried out. Patients were divided into 2 groups: Group 1 (n = 79) had serum LDL levels < or = 70 mg/dl, while Group 2 (n = 124) had levels >70 mg/dl. The first group demonstrated increased odds of hematological cancer by more than 15-fold (OR 15.7, 95% CI 1.78-138.4, p = 0.01). Each 1 mg/dl increase in LDL was associated with a relative reduction of 2.4% in the odds of hematological cancer (OR 0.976, 95% CI 0.956-0.997, p = 0.026). Low LDL levels also increased the odds of fever and sepsis between the groups (OR 5.3, 95% CI 1.8-15.7, p = 0.02). In summary, low serum LDL cholesterol level was associated with increased risks of hematological cancer, fever, and sepsis.</abstract><cop>United States</cop><pmid>18000291</pmid><tpages>6</tpages></addata></record> |
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| ispartof | Annals of clinical and laboratory science, 2007, Vol.37 (4), p.343-348 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Aged Causality Cholesterol, LDL - blood Female Fever - epidemiology Fever - etiology Hematologic Neoplasms - epidemiology Hematologic Neoplasms - etiology Humans Logistic Models Male Retrospective Studies Risk Assessment Risk Factors Sepsis - epidemiology Sepsis - etiology |
| title | Low serum LDL cholesterol levels and the risk of fever, sepsis, and malignancy |
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