Kallikrein–kinin system in inflammatory bowel diseases: Intestinal involvement and correlation with the degree of tissue inflammation
Tissue kallikrein and its natural inhibitor, kallistatin, play opposite roles in the generation of bradykinin, a potent mediator of inflammation. Observations on experimental models and humans with ulcerative colitis suggest a pathogenetic role of the kallikrein–kinin system in inflammatory bowel di...
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| Veröffentlicht in: | Digestive and liver disease 2005-09, Vol.37 (9), p.665-673 |
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| container_title | Digestive and liver disease |
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| creator | Devani, M. Vecchi, M. Ferrero, S. Avesani, E. Contessini Arizzi, C. Chao, L. Colman, R.W. Cugno, M. |
| description | Tissue kallikrein and its natural inhibitor, kallistatin, play opposite roles in the generation of bradykinin, a potent mediator of inflammation. Observations on experimental models and humans with ulcerative colitis suggest a pathogenetic role of the kallikrein–kinin system in inflammatory bowel diseases.
To evaluate tissue kallikrein and kallistatin in intestinal tissue samples from Crohn's disease and ulcerative colitis patients with different degrees of disease involvement.
Full-thickness surgical intestinal samples were obtained from 144 subjects (38 normal controls, 32 inflammatory controls, 38 Crohn's disease, 36 ulcerative colitis) and tested for kallikrein and kallistatin by immunoperoxidase techniques.
Compared with controls, kallikrein immunoreactivity was significantly weaker in goblet cells (
p
=
0.0001) and significantly stronger in interstitium (
p
=
0.0001) of the Crohn's disease and ulcerative colitis samples. Kallistatin colocalised with kallikrein, with almost no reactivity in goblet cells but strong reactivity in interstitium of inflammatory bowel disease patients (
p
=
0.0001 versus controls). The kallikrein and kallistatin depletion of goblet cells and the increased interstitial kallikrein and kallistatin reactivity correlated with the degree of tissue inflammation (
p
=
0.0001). Disease-free samples had normal kallikrein and kallistatin patterns.
Kallikrein–kinin system is actively involved in inflammatory bowel disease as a result of the release of kallikrein in the intestinal extracellular space; this involvement correlates with the degree of tissue inflammation. The normal pattern observed in the disease-free samples seems to rule out a genetic defect of kallikrein and kallistatin in inflammatory bowel diseases. |
| doi_str_mv | 10.1016/j.dld.2005.01.021 |
| format | Article |
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To evaluate tissue kallikrein and kallistatin in intestinal tissue samples from Crohn's disease and ulcerative colitis patients with different degrees of disease involvement.
Full-thickness surgical intestinal samples were obtained from 144 subjects (38 normal controls, 32 inflammatory controls, 38 Crohn's disease, 36 ulcerative colitis) and tested for kallikrein and kallistatin by immunoperoxidase techniques.
Compared with controls, kallikrein immunoreactivity was significantly weaker in goblet cells (
p
=
0.0001) and significantly stronger in interstitium (
p
=
0.0001) of the Crohn's disease and ulcerative colitis samples. Kallistatin colocalised with kallikrein, with almost no reactivity in goblet cells but strong reactivity in interstitium of inflammatory bowel disease patients (
p
=
0.0001 versus controls). The kallikrein and kallistatin depletion of goblet cells and the increased interstitial kallikrein and kallistatin reactivity correlated with the degree of tissue inflammation (
p
=
0.0001). Disease-free samples had normal kallikrein and kallistatin patterns.
Kallikrein–kinin system is actively involved in inflammatory bowel disease as a result of the release of kallikrein in the intestinal extracellular space; this involvement correlates with the degree of tissue inflammation. The normal pattern observed in the disease-free samples seems to rule out a genetic defect of kallikrein and kallistatin in inflammatory bowel diseases.</description><identifier>ISSN: 1590-8658</identifier><identifier>EISSN: 1878-3562</identifier><identifier>DOI: 10.1016/j.dld.2005.01.021</identifier><identifier>PMID: 15949977</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Carrier Proteins - analysis ; Colon - chemistry ; Colon - pathology ; Crohn's disease ; Female ; Humans ; Immunohistochemistry ; Inflammatory Bowel Diseases - pathology ; Inflammatory Bowel Diseases - physiopathology ; Intestinal tissue kallikrein ; Kallikrein-Kinin System ; Kallikreins - analysis ; Kallistatin ; Male ; Middle Aged ; Serpins - analysis ; Ulcerative colitis</subject><ispartof>Digestive and liver disease, 2005-09, Vol.37 (9), p.665-673</ispartof><rights>2005 Editrice Gastroenterologica Italiana S.r.l.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c351t-2d6ae04f45a046b1fea484be67ef2cce4ca249f6ae741de42d73d7c80ed0a1b73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.dld.2005.01.021$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15949977$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Devani, M.</creatorcontrib><creatorcontrib>Vecchi, M.</creatorcontrib><creatorcontrib>Ferrero, S.</creatorcontrib><creatorcontrib>Avesani, E. Contessini</creatorcontrib><creatorcontrib>Arizzi, C.</creatorcontrib><creatorcontrib>Chao, L.</creatorcontrib><creatorcontrib>Colman, R.W.</creatorcontrib><creatorcontrib>Cugno, M.</creatorcontrib><title>Kallikrein–kinin system in inflammatory bowel diseases: Intestinal involvement and correlation with the degree of tissue inflammation</title><title>Digestive and liver disease</title><addtitle>Dig Liver Dis</addtitle><description>Tissue kallikrein and its natural inhibitor, kallistatin, play opposite roles in the generation of bradykinin, a potent mediator of inflammation. Observations on experimental models and humans with ulcerative colitis suggest a pathogenetic role of the kallikrein–kinin system in inflammatory bowel diseases.
To evaluate tissue kallikrein and kallistatin in intestinal tissue samples from Crohn's disease and ulcerative colitis patients with different degrees of disease involvement.
Full-thickness surgical intestinal samples were obtained from 144 subjects (38 normal controls, 32 inflammatory controls, 38 Crohn's disease, 36 ulcerative colitis) and tested for kallikrein and kallistatin by immunoperoxidase techniques.
Compared with controls, kallikrein immunoreactivity was significantly weaker in goblet cells (
p
=
0.0001) and significantly stronger in interstitium (
p
=
0.0001) of the Crohn's disease and ulcerative colitis samples. Kallistatin colocalised with kallikrein, with almost no reactivity in goblet cells but strong reactivity in interstitium of inflammatory bowel disease patients (
p
=
0.0001 versus controls). The kallikrein and kallistatin depletion of goblet cells and the increased interstitial kallikrein and kallistatin reactivity correlated with the degree of tissue inflammation (
p
=
0.0001). Disease-free samples had normal kallikrein and kallistatin patterns.
Kallikrein–kinin system is actively involved in inflammatory bowel disease as a result of the release of kallikrein in the intestinal extracellular space; this involvement correlates with the degree of tissue inflammation. The normal pattern observed in the disease-free samples seems to rule out a genetic defect of kallikrein and kallistatin in inflammatory bowel diseases.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carrier Proteins - analysis</subject><subject>Colon - chemistry</subject><subject>Colon - pathology</subject><subject>Crohn's disease</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Inflammatory Bowel Diseases - pathology</subject><subject>Inflammatory Bowel Diseases - physiopathology</subject><subject>Intestinal tissue kallikrein</subject><subject>Kallikrein-Kinin System</subject><subject>Kallikreins - analysis</subject><subject>Kallistatin</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Serpins - analysis</subject><subject>Ulcerative colitis</subject><issn>1590-8658</issn><issn>1878-3562</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM9OGzEQh62qCGjKA_RS-dTbbse73j8pJxS1FDUSFzhbXnu2OHhtajtBuXHjAXhDnqSOEokbpxlpvvlp5iPkC4OSAWu_r0ptdVkBNCWwEir2gZyyvuuLummrj7lv5lD0bdOfkE8xriATbQPH5CQP-Hzedafk-Y-01twHNO716eXeOONo3MaEE82dcaOV0ySTD1s6-Ee0VJuIMmL8Qa9cwpiMkzZzG283OKFLVDpNlQ8BrUzGO_po0h1Nd0g1_g2I1I80mRjX-Jaesc_kaJQ24tmhzsjtr583i9_F8vryanGxLFTdsFRUupUIfOSNBN4ObETJez5g2-FYKYVcyYrPxwx1nGnkle5q3akeUINkQ1fPyLd97kPw_9b5fjGZqNBa6dCvo2j7BqoadiDbgyr4GAOO4iGYSYatYCB29sVKZPtiZ18AE9lt3vl6CF8PE-q3jYPuDJzvAcwvbgwGEZVBp1CbgCoJ7c078f8Bhj-a5g</recordid><startdate>20050901</startdate><enddate>20050901</enddate><creator>Devani, M.</creator><creator>Vecchi, M.</creator><creator>Ferrero, S.</creator><creator>Avesani, E. Contessini</creator><creator>Arizzi, C.</creator><creator>Chao, L.</creator><creator>Colman, R.W.</creator><creator>Cugno, M.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050901</creationdate><title>Kallikrein–kinin system in inflammatory bowel diseases: Intestinal involvement and correlation with the degree of tissue inflammation</title><author>Devani, M. ; Vecchi, M. ; Ferrero, S. ; Avesani, E. Contessini ; Arizzi, C. ; Chao, L. ; Colman, R.W. ; Cugno, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-2d6ae04f45a046b1fea484be67ef2cce4ca249f6ae741de42d73d7c80ed0a1b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carrier Proteins - analysis</topic><topic>Colon - chemistry</topic><topic>Colon - pathology</topic><topic>Crohn's disease</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Inflammatory Bowel Diseases - pathology</topic><topic>Inflammatory Bowel Diseases - physiopathology</topic><topic>Intestinal tissue kallikrein</topic><topic>Kallikrein-Kinin System</topic><topic>Kallikreins - analysis</topic><topic>Kallistatin</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Serpins - analysis</topic><topic>Ulcerative colitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Devani, M.</creatorcontrib><creatorcontrib>Vecchi, M.</creatorcontrib><creatorcontrib>Ferrero, S.</creatorcontrib><creatorcontrib>Avesani, E. Contessini</creatorcontrib><creatorcontrib>Arizzi, C.</creatorcontrib><creatorcontrib>Chao, L.</creatorcontrib><creatorcontrib>Colman, R.W.</creatorcontrib><creatorcontrib>Cugno, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive and liver disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Devani, M.</au><au>Vecchi, M.</au><au>Ferrero, S.</au><au>Avesani, E. Contessini</au><au>Arizzi, C.</au><au>Chao, L.</au><au>Colman, R.W.</au><au>Cugno, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Kallikrein–kinin system in inflammatory bowel diseases: Intestinal involvement and correlation with the degree of tissue inflammation</atitle><jtitle>Digestive and liver disease</jtitle><addtitle>Dig Liver Dis</addtitle><date>2005-09-01</date><risdate>2005</risdate><volume>37</volume><issue>9</issue><spage>665</spage><epage>673</epage><pages>665-673</pages><issn>1590-8658</issn><eissn>1878-3562</eissn><abstract>Tissue kallikrein and its natural inhibitor, kallistatin, play opposite roles in the generation of bradykinin, a potent mediator of inflammation. Observations on experimental models and humans with ulcerative colitis suggest a pathogenetic role of the kallikrein–kinin system in inflammatory bowel diseases.
To evaluate tissue kallikrein and kallistatin in intestinal tissue samples from Crohn's disease and ulcerative colitis patients with different degrees of disease involvement.
Full-thickness surgical intestinal samples were obtained from 144 subjects (38 normal controls, 32 inflammatory controls, 38 Crohn's disease, 36 ulcerative colitis) and tested for kallikrein and kallistatin by immunoperoxidase techniques.
Compared with controls, kallikrein immunoreactivity was significantly weaker in goblet cells (
p
=
0.0001) and significantly stronger in interstitium (
p
=
0.0001) of the Crohn's disease and ulcerative colitis samples. Kallistatin colocalised with kallikrein, with almost no reactivity in goblet cells but strong reactivity in interstitium of inflammatory bowel disease patients (
p
=
0.0001 versus controls). The kallikrein and kallistatin depletion of goblet cells and the increased interstitial kallikrein and kallistatin reactivity correlated with the degree of tissue inflammation (
p
=
0.0001). Disease-free samples had normal kallikrein and kallistatin patterns.
Kallikrein–kinin system is actively involved in inflammatory bowel disease as a result of the release of kallikrein in the intestinal extracellular space; this involvement correlates with the degree of tissue inflammation. The normal pattern observed in the disease-free samples seems to rule out a genetic defect of kallikrein and kallistatin in inflammatory bowel diseases.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>15949977</pmid><doi>10.1016/j.dld.2005.01.021</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1590-8658 |
| ispartof | Digestive and liver disease, 2005-09, Vol.37 (9), p.665-673 |
| issn | 1590-8658 1878-3562 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68502307 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Aged Aged, 80 and over Carrier Proteins - analysis Colon - chemistry Colon - pathology Crohn's disease Female Humans Immunohistochemistry Inflammatory Bowel Diseases - pathology Inflammatory Bowel Diseases - physiopathology Intestinal tissue kallikrein Kallikrein-Kinin System Kallikreins - analysis Kallistatin Male Middle Aged Serpins - analysis Ulcerative colitis |
| title | Kallikrein–kinin system in inflammatory bowel diseases: Intestinal involvement and correlation with the degree of tissue inflammation |
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