Cumulative and Bolus In Vitro Contracture Testing with 4-Chloro-3-Ethylphenol in Malignant Hyperthermia Positive and Negative Human Skeletal Muscles
In this study we evaluated the in vitro effects of 4-chloro-3-ethylphenol (CEP) using cumulative (12.5–200 μmol/L) or bolus (75 and 100 μmol/L) administrations, on muscle specimens from malignant hyperthermia (MH) susceptible and MH nonsusceptible patients, respectively. In the cumulative CEP in vit...
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| Veröffentlicht in: | Anesthesia and analgesia 2005-09, Vol.101 (3), p.710-714 |
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| container_title | Anesthesia and analgesia |
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| creator | Gerbershagen, Mark Ulrich Fiege, Marko Weisshorn, Ralf Kolodzie, Kerstin Esch, Jochen Schulte am Wappler, Frank |
| description | In this study we evaluated the in vitro effects of 4-chloro-3-ethylphenol (CEP) using cumulative (12.5–200 μmol/L) or bolus (75 and 100 μmol/L) administrations, on muscle specimens from malignant hyperthermia (MH) susceptible and MH nonsusceptible patients, respectively. In the cumulative CEP in vitro contracture test, contractures were significantly greater in the MH susceptible compared with the MH nonsusceptible muscles in all concentrations between 25 and 100 μmol/L. There was no overlap between the diagnostic groups at 75 μmol/L of CEP, so this test appears to be feasible for diagnosis of MH susceptibility. The two bolus tests are not diagnostically useful, as overlaps between the diagnostic groups were observed. |
| doi_str_mv | 10.1213/01.ANE.0000160534.23519.1B |
| format | Article |
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In the cumulative CEP in vitro contracture test, contractures were significantly greater in the MH susceptible compared with the MH nonsusceptible muscles in all concentrations between 25 and 100 μmol/L. There was no overlap between the diagnostic groups at 75 μmol/L of CEP, so this test appears to be feasible for diagnosis of MH susceptibility. The two bolus tests are not diagnostically useful, as overlaps between the diagnostic groups were observed.</description><identifier>ISSN: 0003-2999</identifier><identifier>EISSN: 1526-7598</identifier><identifier>DOI: 10.1213/01.ANE.0000160534.23519.1B</identifier><identifier>PMID: 16115979</identifier><identifier>CODEN: AACRAT</identifier><language>eng</language><publisher>Hagerstown, MD: International Anesthesia Research Society</publisher><subject>Adolescent ; Adult ; Aged ; Anesthesia ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Child ; Child, Preschool ; Chlorophenols - pharmacology ; Dimethyl Sulfoxide ; Female ; Humans ; In Vitro Techniques ; Male ; Malignant Hyperthermia - diagnosis ; Malignant Hyperthermia - physiopathology ; Medical sciences ; Middle Aged ; Muscle, Skeletal - drug effects ; Predictive Value of Tests</subject><ispartof>Anesthesia and analgesia, 2005-09, Vol.101 (3), p.710-714</ispartof><rights>International Anesthesia Research Society</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4440-9811b392429a92b73a53794eaaccdb18a8701d76edfbeab3ba2b3f9d4a40a9513</citedby><cites>FETCH-LOGICAL-c4440-9811b392429a92b73a53794eaaccdb18a8701d76edfbeab3ba2b3f9d4a40a9513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf><![CDATA[$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&PDF=y&D=ovft&AN=00000539-200509000-00020$$EPDF$$P50$$Gwolterskluwer$$H]]></linktopdf><linktohtml>$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00000539-200509000-00020$$EHTML$$P50$$Gwolterskluwer$$H</linktohtml><link.rule.ids>314,780,784,4609,27924,27925,64666,65461</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17201162$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16115979$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gerbershagen, Mark Ulrich</creatorcontrib><creatorcontrib>Fiege, Marko</creatorcontrib><creatorcontrib>Weisshorn, Ralf</creatorcontrib><creatorcontrib>Kolodzie, Kerstin</creatorcontrib><creatorcontrib>Esch, Jochen Schulte am</creatorcontrib><creatorcontrib>Wappler, Frank</creatorcontrib><title>Cumulative and Bolus In Vitro Contracture Testing with 4-Chloro-3-Ethylphenol in Malignant Hyperthermia Positive and Negative Human Skeletal Muscles</title><title>Anesthesia and analgesia</title><addtitle>Anesth Analg</addtitle><description>In this study we evaluated the in vitro effects of 4-chloro-3-ethylphenol (CEP) using cumulative (12.5–200 μmol/L) or bolus (75 and 100 μmol/L) administrations, on muscle specimens from malignant hyperthermia (MH) susceptible and MH nonsusceptible patients, respectively. In the cumulative CEP in vitro contracture test, contractures were significantly greater in the MH susceptible compared with the MH nonsusceptible muscles in all concentrations between 25 and 100 μmol/L. There was no overlap between the diagnostic groups at 75 μmol/L of CEP, so this test appears to be feasible for diagnosis of MH susceptibility. The two bolus tests are not diagnostically useful, as overlaps between the diagnostic groups were observed.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anesthesia</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chlorophenols - pharmacology</subject><subject>Dimethyl Sulfoxide</subject><subject>Female</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Malignant Hyperthermia - diagnosis</subject><subject>Malignant Hyperthermia - physiopathology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Muscle, Skeletal - drug effects</subject><subject>Predictive Value of Tests</subject><issn>0003-2999</issn><issn>1526-7598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkW-LEzEQhxdRvPP0K0gQ9N3WTLL_4rtrqfbg7hQ8fRtmd9NuvGxSk6yl38MPbHotdiAMgWfmx_Bk2TugM2DAP1KYXd8vZzQVVLTkxYzxEsQM5s-ySyhZldelaJ5nlwngORNCXGSvQvh14GlTvcwuoAIoRS0us7-LaZwMRv1HEbQ9mTszBXJjyU8dvSMLZ6PHLk5ekQcVorYbstNxIEW-GIzzLuf5Mg57sx2UdYZoS-7Q6I1FG8lqv1U-DsqPGsk3F_T_lHu1OUauphEt-f6ojIpoyN0UOqPC6-zFGk1Qb079KvvxefmwWOW3X7_cLK5v864oCpqLBqDlghVMoGBtzbHktSgUYtf1LTTY1BT6ulL9ulXY8hZZy9eiL7CgKErgV9mH496td7-ndJ4cdeiUMWiVm4KsmpIyEAfw0xHsvAvBq7Xcej2i30ug8uBEUpDJiTw7kU9OJMzT8NtTytSOqj-PniQk4P0JwNChWXu0nQ5nrmYUoGKJK47czpmofHg00055OSg0cXiKTsEiZ6lRkT55eozyf4Hsprw</recordid><startdate>20050901</startdate><enddate>20050901</enddate><creator>Gerbershagen, Mark Ulrich</creator><creator>Fiege, Marko</creator><creator>Weisshorn, Ralf</creator><creator>Kolodzie, Kerstin</creator><creator>Esch, Jochen Schulte am</creator><creator>Wappler, Frank</creator><general>International Anesthesia Research Society</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050901</creationdate><title>Cumulative and Bolus In Vitro Contracture Testing with 4-Chloro-3-Ethylphenol in Malignant Hyperthermia Positive and Negative Human Skeletal Muscles</title><author>Gerbershagen, Mark Ulrich ; Fiege, Marko ; Weisshorn, Ralf ; Kolodzie, Kerstin ; Esch, Jochen Schulte am ; Wappler, Frank</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4440-9811b392429a92b73a53794eaaccdb18a8701d76edfbeab3ba2b3f9d4a40a9513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anesthesia</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chlorophenols - pharmacology</topic><topic>Dimethyl Sulfoxide</topic><topic>Female</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Malignant Hyperthermia - diagnosis</topic><topic>Malignant Hyperthermia - physiopathology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Muscle, Skeletal - drug effects</topic><topic>Predictive Value of Tests</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gerbershagen, Mark Ulrich</creatorcontrib><creatorcontrib>Fiege, Marko</creatorcontrib><creatorcontrib>Weisshorn, Ralf</creatorcontrib><creatorcontrib>Kolodzie, Kerstin</creatorcontrib><creatorcontrib>Esch, Jochen Schulte am</creatorcontrib><creatorcontrib>Wappler, Frank</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Anesthesia and analgesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gerbershagen, Mark Ulrich</au><au>Fiege, Marko</au><au>Weisshorn, Ralf</au><au>Kolodzie, Kerstin</au><au>Esch, Jochen Schulte am</au><au>Wappler, Frank</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cumulative and Bolus In Vitro Contracture Testing with 4-Chloro-3-Ethylphenol in Malignant Hyperthermia Positive and Negative Human Skeletal Muscles</atitle><jtitle>Anesthesia and analgesia</jtitle><addtitle>Anesth Analg</addtitle><date>2005-09-01</date><risdate>2005</risdate><volume>101</volume><issue>3</issue><spage>710</spage><epage>714</epage><pages>710-714</pages><issn>0003-2999</issn><eissn>1526-7598</eissn><coden>AACRAT</coden><abstract>In this study we evaluated the in vitro effects of 4-chloro-3-ethylphenol (CEP) using cumulative (12.5–200 μmol/L) or bolus (75 and 100 μmol/L) administrations, on muscle specimens from malignant hyperthermia (MH) susceptible and MH nonsusceptible patients, respectively. In the cumulative CEP in vitro contracture test, contractures were significantly greater in the MH susceptible compared with the MH nonsusceptible muscles in all concentrations between 25 and 100 μmol/L. There was no overlap between the diagnostic groups at 75 μmol/L of CEP, so this test appears to be feasible for diagnosis of MH susceptibility. The two bolus tests are not diagnostically useful, as overlaps between the diagnostic groups were observed.</abstract><cop>Hagerstown, MD</cop><pub>International Anesthesia Research Society</pub><pmid>16115979</pmid><doi>10.1213/01.ANE.0000160534.23519.1B</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Anesthesia and analgesia, 2005-09, Vol.101 (3), p.710-714 |
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| source | Ovid Lippincott Williams and Wilkins Journal Legacy Archive; MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adult Aged Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Child Child, Preschool Chlorophenols - pharmacology Dimethyl Sulfoxide Female Humans In Vitro Techniques Male Malignant Hyperthermia - diagnosis Malignant Hyperthermia - physiopathology Medical sciences Middle Aged Muscle, Skeletal - drug effects Predictive Value of Tests |
| title | Cumulative and Bolus In Vitro Contracture Testing with 4-Chloro-3-Ethylphenol in Malignant Hyperthermia Positive and Negative Human Skeletal Muscles |
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