Multiple genetic and epigenetic biomarkers for lung cancer detection in cytologically negative sputum and a nested case-control study for risk assessment

The purpose of this study was to define a biomarker panel for detection of cancer cells in cytologically negative sputum and to evaluate the panel for assessment of lung cancer risk. We examined 19 genetic and epigenetic markers using a sensitive fluorescence-based method in cytologically negative s...

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Veröffentlicht in:	The Journal of pathology 2007-12, Vol.213 (4), p.412-419
Hauptverfasser:	Hsu, H.S, Chen, T.P, Wen, C.K, Hung, C.H, Chen, C.Y, Chen, J.T, Wang, Y.C
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Anhydride Hydrolases - genetics Base Sequence Biological and medical sciences Biomarkers, Tumor - genetics Carcinoma, Non-Small-Cell Lung - diagnosis Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Case-Control Studies case-control study DNA Methylation Epigenesis, Genetic Female Genes, p16 Genetic Markers Humans Investigative techniques, diagnostic techniques (general aspects) LOH Loss of Heterozygosity Lung Neoplasms - diagnosis Lung Neoplasms - genetics Lung Neoplasms - pathology Male Medical sciences Microsatellite Instability Molecular Sequence Data MSI MSP Neoplasm Proteins - genetics Neoplasm Staging NSCLC Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Pneumology Promoter Regions, Genetic - genetics Receptors, Retinoic Acid - genetics Risk Assessment - methods Sensitivity and Specificity sputum Sputum - cytology Tumors of the respiratory system and mediastinum
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