Characterization of functional and morphological changes in a rat model of colitis induced by Trichinella spiralis
We intended to characterize the effect of inflammation on the spontaneous colonic motility pattern and the role of iNOS in its disruption in colitis. Colitis was induced by an intracolonic enema of T. spiralis larvae. Animals were studied 2-30 days postinfection (PI). Standard H&E and iNOS stain...
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| Veröffentlicht in: | Digestive diseases and sciences 2005-08, Vol.50 (8), p.1432-1443 |
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| description | We intended to characterize the effect of inflammation on the spontaneous colonic motility pattern and the role of iNOS in its disruption in colitis. Colitis was induced by an intracolonic enema of T. spiralis larvae. Animals were studied 2-30 days postinfection (PI). Standard H&E and iNOS staining was performed on colonic sections. Altered stool consistency was found from day 1 to day 21 PI; leukocytosis peaked on days 6-21 PI. Edema and cell infiltration were found in mucosa and submucosa (days 2-14 PI). Contractility displayed a disorganized pattern with decreased high-amplitude, low-frequency (HALF) contractions. A progressive fading of spontaneous activity was observed and was partly restored in strips devoid of submucosa. iNOS immunoreactivity increased in epithelial and infiltrating cells (days 2-14 PI). In this model of colonic inflammation, the decrease in spontaneous contractility, which might be caused by NO generated from mucosal and submucosal iNOS, bears some traits with changes observed in ulcerative colitis and might thus be useful to study the dismotility observed in this human disease. |
| doi_str_mv | 10.1007/s10620-005-2858-4 |
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Colitis was induced by an intracolonic enema of T. spiralis larvae. Animals were studied 2-30 days postinfection (PI). Standard H&E and iNOS staining was performed on colonic sections. Altered stool consistency was found from day 1 to day 21 PI; leukocytosis peaked on days 6-21 PI. Edema and cell infiltration were found in mucosa and submucosa (days 2-14 PI). Contractility displayed a disorganized pattern with decreased high-amplitude, low-frequency (HALF) contractions. A progressive fading of spontaneous activity was observed and was partly restored in strips devoid of submucosa. iNOS immunoreactivity increased in epithelial and infiltrating cells (days 2-14 PI). In this model of colonic inflammation, the decrease in spontaneous contractility, which might be caused by NO generated from mucosal and submucosal iNOS, bears some traits with changes observed in ulcerative colitis and might thus be useful to study the dismotility observed in this human disease.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-005-2858-4</identifier><identifier>PMID: 16110832</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Animals ; Biological and medical sciences ; Colitis, Ulcerative - enzymology ; Colitis, Ulcerative - pathology ; Colitis, Ulcerative - physiopathology ; Colon - enzymology ; Colon - pathology ; Colon - physiopathology ; Disease Models, Animal ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; Gastrointestinal Motility - physiology ; Male ; Muscle Contraction - physiology ; Muscle, Smooth - physiology ; Nitric Oxide Synthase - metabolism ; Nitric Oxide Synthase Type II ; Rats ; Rats, Sprague-Dawley ; Time Factors ; Trichinella spiralis ; Trichinellosis - enzymology ; Trichinellosis - pathology ; Trichinellosis - physiopathology ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Weight Loss</subject><ispartof>Digestive diseases and sciences, 2005-08, Vol.50 (8), p.1432-1443</ispartof><rights>2006 INIST-CNRS</rights><rights>Springer Science + Business Media, Inc. 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-65a5b89932add1759c9cbccec47f6fe26c3a5b920ffd774e8c6e05cabf01e1aa3</citedby><cites>FETCH-LOGICAL-c356t-65a5b89932add1759c9cbccec47f6fe26c3a5b920ffd774e8c6e05cabf01e1aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17299319$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16110832$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>AULI, Mariona</creatorcontrib><creatorcontrib>FERNANDEZ, Ester</creatorcontrib><title>Characterization of functional and morphological changes in a rat model of colitis induced by Trichinella spiralis</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><description>We intended to characterize the effect of inflammation on the spontaneous colonic motility pattern and the role of iNOS in its disruption in colitis. Colitis was induced by an intracolonic enema of T. spiralis larvae. Animals were studied 2-30 days postinfection (PI). Standard H&E and iNOS staining was performed on colonic sections. Altered stool consistency was found from day 1 to day 21 PI; leukocytosis peaked on days 6-21 PI. Edema and cell infiltration were found in mucosa and submucosa (days 2-14 PI). Contractility displayed a disorganized pattern with decreased high-amplitude, low-frequency (HALF) contractions. A progressive fading of spontaneous activity was observed and was partly restored in strips devoid of submucosa. iNOS immunoreactivity increased in epithelial and infiltrating cells (days 2-14 PI). In this model of colonic inflammation, the decrease in spontaneous contractility, which might be caused by NO generated from mucosal and submucosal iNOS, bears some traits with changes observed in ulcerative colitis and might thus be useful to study the dismotility observed in this human disease.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Colitis, Ulcerative - enzymology</subject><subject>Colitis, Ulcerative - pathology</subject><subject>Colitis, Ulcerative - physiopathology</subject><subject>Colon - enzymology</subject><subject>Colon - pathology</subject><subject>Colon - physiopathology</subject><subject>Disease Models, Animal</subject><subject>Feeding. Feeding behavior</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastrointestinal Motility - physiology</subject><subject>Male</subject><subject>Muscle Contraction - physiology</subject><subject>Muscle, Smooth - physiology</subject><subject>Nitric Oxide Synthase - metabolism</subject><subject>Nitric Oxide Synthase Type II</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Time Factors</subject><subject>Trichinella spiralis</subject><subject>Trichinellosis - enzymology</subject><subject>Trichinellosis - pathology</subject><subject>Trichinellosis - physiopathology</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Weight Loss</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkcGO1DAMhiMEYmcXHoALipDgVoiTJmmPaAQs0kpclnPkuslOVp1mSNrD8vSkmpFW4mTL_vzL9s_YOxCfQQj7pYAwUjRC6EZ2umvaF2wH2qpGatO9ZDsBpuYA5opdl_IohOgtmNfsCgyA6JTcsbw_YEZafI5_cYlp5inwsM605ThxnEd-TPl0SFN6iFQrdMD5wRceZ44841Lbo5-2MUpTXOLWGVfyIx-e-H2OdIiznybk5RQzTrG8Ya8CTsW_vcQb9vv7t_v9bXP368fP_de7hpQ2S2M06qHreyVxHMHqnnoaiDy1NpjgpSFVgV6KEEZrW9-R8UITDkGAB0R1wz6ddU85_Vl9WdwxFtpWmX1aizOdFiBlW8EP_4GPac31-uIktEpZ0KJCcIYop1KyD-6U4xHzkwPhNjfc2Q1X3XCbG24Tfn8RXoejH58nLu-vwMcLgKX-NmScKZZnzsp6P_TqH7HplCg</recordid><startdate>20050801</startdate><enddate>20050801</enddate><creator>AULI, Mariona</creator><creator>FERNANDEZ, Ester</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20050801</creationdate><title>Characterization of functional and morphological changes in a rat model of colitis induced by Trichinella spiralis</title><author>AULI, Mariona ; FERNANDEZ, Ester</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-65a5b89932add1759c9cbccec47f6fe26c3a5b920ffd774e8c6e05cabf01e1aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Colitis, Ulcerative - enzymology</topic><topic>Colitis, Ulcerative - pathology</topic><topic>Colitis, Ulcerative - physiopathology</topic><topic>Colon - enzymology</topic><topic>Colon - pathology</topic><topic>Colon - physiopathology</topic><topic>Disease Models, Animal</topic><topic>Feeding. Feeding behavior</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastrointestinal Motility - physiology</topic><topic>Male</topic><topic>Muscle Contraction - physiology</topic><topic>Muscle, Smooth - physiology</topic><topic>Nitric Oxide Synthase - metabolism</topic><topic>Nitric Oxide Synthase Type II</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Time Factors</topic><topic>Trichinella spiralis</topic><topic>Trichinellosis - enzymology</topic><topic>Trichinellosis - pathology</topic><topic>Trichinellosis - physiopathology</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Weight Loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>AULI, Mariona</creatorcontrib><creatorcontrib>FERNANDEZ, Ester</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>AULI, Mariona</au><au>FERNANDEZ, Ester</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of functional and morphological changes in a rat model of colitis induced by Trichinella spiralis</atitle><jtitle>Digestive diseases and sciences</jtitle><addtitle>Dig Dis Sci</addtitle><date>2005-08-01</date><risdate>2005</risdate><volume>50</volume><issue>8</issue><spage>1432</spage><epage>1443</epage><pages>1432-1443</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>We intended to characterize the effect of inflammation on the spontaneous colonic motility pattern and the role of iNOS in its disruption in colitis. Colitis was induced by an intracolonic enema of T. spiralis larvae. Animals were studied 2-30 days postinfection (PI). Standard H&E and iNOS staining was performed on colonic sections. Altered stool consistency was found from day 1 to day 21 PI; leukocytosis peaked on days 6-21 PI. Edema and cell infiltration were found in mucosa and submucosa (days 2-14 PI). Contractility displayed a disorganized pattern with decreased high-amplitude, low-frequency (HALF) contractions. A progressive fading of spontaneous activity was observed and was partly restored in strips devoid of submucosa. iNOS immunoreactivity increased in epithelial and infiltrating cells (days 2-14 PI). In this model of colonic inflammation, the decrease in spontaneous contractility, which might be caused by NO generated from mucosal and submucosal iNOS, bears some traits with changes observed in ulcerative colitis and might thus be useful to study the dismotility observed in this human disease.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>16110832</pmid><doi>10.1007/s10620-005-2858-4</doi><tpages>12</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Colitis, Ulcerative - enzymology Colitis, Ulcerative - pathology Colitis, Ulcerative - physiopathology Colon - enzymology Colon - pathology Colon - physiopathology Disease Models, Animal Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Gastrointestinal Motility - physiology Male Muscle Contraction - physiology Muscle, Smooth - physiology Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type II Rats Rats, Sprague-Dawley Time Factors Trichinella spiralis Trichinellosis - enzymology Trichinellosis - pathology Trichinellosis - physiopathology Vertebrates: anatomy and physiology, studies on body, several organs or systems Weight Loss |
| title | Characterization of functional and morphological changes in a rat model of colitis induced by Trichinella spiralis |
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