Quantitative determination of ketoprofen in gels and ampules by using flow-injection UV spectrophotometry and HPLC
A flow-injection UV spectrophotometric method for the determination of ketoprofen in gels and ampules was developed. Quantitative determination of ketoprofen was realized by using distilled water as a carrier for gels and citrate buffer, pH 6.5, for ampules at 261 nm. No spectrophotometric interfere...
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| Veröffentlicht in: | Journal of pharmaceutical and biomedical analysis 2005-09, Vol.39 (3), p.606-611 |
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| creator | Özlü, Cihad Basan, Hasan Şatana, Eda Ertaş, Nusret Göğer, Nilgün G. |
| description | A flow-injection UV spectrophotometric method for the determination of ketoprofen in gels and ampules was developed. Quantitative determination of ketoprofen was realized by using distilled water as a carrier for gels and citrate buffer, pH 6.5, for ampules at 261
nm. No spectrophotometric interferences from additives of gels, carboxypolymethylene and triethanolamine, were observed. There were also no spectrophotometric interferences resulting from additives of ampules named as benzyl alcohol and arginine. The detection limits were 0.436 and 0.303
μg/ml for gels and ampules, respectively. Throughout the study, the flow rate, loop volume and the number of injection per hour were 13.8
ml
min
−1, 193
μl and 85, respectively. Analytical signal of the ketoprofen was linear in the concentration range of 7.5–75
μg/ml. Quantitative results of ketoprofen in gels, 25.25
±
0.27 (mean
±
S.D.), and in ampules, 99.42
±
0.44 were in good agreement with the labeled quantities (25
mg/1
g gel, 100
mg/2
ml ampule). The recoveries were in the range of 98.65–100.63 and 99.1–101.5% for gels and ampules, respectively.
Results obtained were in accordance with those obtained by HPLC. It was seen that the proposed method was fast, accurate, precise and suitable for automation as an analytical method. |
| doi_str_mv | 10.1016/j.jpba.2005.04.002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68501194</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0731708505002517</els_id><sourcerecordid>68501194</sourcerecordid><originalsourceid>FETCH-LOGICAL-c450t-f014fc2cd3af55b775d4202af28776a3f10891028cd115e714a0143b72a1a0fb3</originalsourceid><addsrcrecordid>eNp9kUGP1CAYQInRuLOrf8CD4aK31g9aSifxYia6azKJmrjGG6H0Y6W2UKFdM_9eZmeSvXkCkve-wIOQVwxKBqx5N5TD3OmSA4gS6hKAPyEb1sqq4E398ynZgKxYIaEVF-QypQEyyLb1c3LBRLtttjVsSPy2ar-4RS_uHmmPC8bJ-XwKngZLf-MS5hgseuo8vcMxUe17qqd5HTHR7kDX5PwdtWP4Wzg_oHkwb3_QNOd9DPOvsIQJl3h4EG--7ncvyDOrx4Qvz-sVuf308fvupth_uf68-7AvTC1gKSyw2hpu-kpbITopRV9z4NryVspGV5ZBu2XAW9MzJlCyWmej6iTXTIPtqivy9jQ3P-DPimlRk0sGx1F7DGtSTSuA5R4Z5CfQxJBSRKvm6CYdD4qBOpZWgzqWVsfSCmqVS2fp9Xn62k3YPyrntBl4cwZ0Mnq0UXvj0iMnRf6qbZO59ycux8V7h1El49Ab7F3MCVUf3P_u8Q8W6J2X</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68501194</pqid></control><display><type>article</type><title>Quantitative determination of ketoprofen in gels and ampules by using flow-injection UV spectrophotometry and HPLC</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Özlü, Cihad ; Basan, Hasan ; Şatana, Eda ; Ertaş, Nusret ; Göğer, Nilgün G.</creator><creatorcontrib>Özlü, Cihad ; Basan, Hasan ; Şatana, Eda ; Ertaş, Nusret ; Göğer, Nilgün G.</creatorcontrib><description>A flow-injection UV spectrophotometric method for the determination of ketoprofen in gels and ampules was developed. Quantitative determination of ketoprofen was realized by using distilled water as a carrier for gels and citrate buffer, pH 6.5, for ampules at 261
nm. No spectrophotometric interferences from additives of gels, carboxypolymethylene and triethanolamine, were observed. There were also no spectrophotometric interferences resulting from additives of ampules named as benzyl alcohol and arginine. The detection limits were 0.436 and 0.303
μg/ml for gels and ampules, respectively. Throughout the study, the flow rate, loop volume and the number of injection per hour were 13.8
ml
min
−1, 193
μl and 85, respectively. Analytical signal of the ketoprofen was linear in the concentration range of 7.5–75
μg/ml. Quantitative results of ketoprofen in gels, 25.25
±
0.27 (mean
±
S.D.), and in ampules, 99.42
±
0.44 were in good agreement with the labeled quantities (25
mg/1
g gel, 100
mg/2
ml ampule). The recoveries were in the range of 98.65–100.63 and 99.1–101.5% for gels and ampules, respectively.
Results obtained were in accordance with those obtained by HPLC. It was seen that the proposed method was fast, accurate, precise and suitable for automation as an analytical method.</description><identifier>ISSN: 0731-7085</identifier><identifier>EISSN: 1873-264X</identifier><identifier>DOI: 10.1016/j.jpba.2005.04.002</identifier><identifier>PMID: 15896940</identifier><identifier>CODEN: JPBADA</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Acrylic Resins ; Ampules ; Analysis ; Analytical, structural and metabolic biochemistry ; Anti-Inflammatory Agents, Non-Steroidal - analysis ; Anti-Inflammatory Agents, Non-Steroidal - chemistry ; Arginine - analysis ; Benzyl Alcohols - analysis ; Biological and medical sciences ; Buffers ; Calibration ; Chemistry, Pharmaceutical - methods ; Chromatography, High Pressure Liquid - methods ; Chromatography, Thin Layer ; Dose-Response Relationship, Drug ; Drug Stability ; Ethanolamines - analysis ; Flow-injection analysis ; Fundamental and applied biological sciences. Psychology ; Gels ; General pharmacology ; Hydrogen-Ion Concentration ; Ketoprofen ; Ketoprofen - analysis ; Ketoprofen - chemistry ; Medical sciences ; Models, Chemical ; Pharmacology. Drug treatments ; Polyvinyls - analysis ; Reproducibility of Results ; Spectrophotometry ; Spectrophotometry, Ultraviolet - methods ; Tablets ; Technology, Pharmaceutical - methods ; Ultraviolet Rays ; UV–vis spectrophotometry</subject><ispartof>Journal of pharmaceutical and biomedical analysis, 2005-09, Vol.39 (3), p.606-611</ispartof><rights>2005</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-f014fc2cd3af55b775d4202af28776a3f10891028cd115e714a0143b72a1a0fb3</citedby><cites>FETCH-LOGICAL-c450t-f014fc2cd3af55b775d4202af28776a3f10891028cd115e714a0143b72a1a0fb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpba.2005.04.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3554,27933,27934,46004</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17518796$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15896940$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Özlü, Cihad</creatorcontrib><creatorcontrib>Basan, Hasan</creatorcontrib><creatorcontrib>Şatana, Eda</creatorcontrib><creatorcontrib>Ertaş, Nusret</creatorcontrib><creatorcontrib>Göğer, Nilgün G.</creatorcontrib><title>Quantitative determination of ketoprofen in gels and ampules by using flow-injection UV spectrophotometry and HPLC</title><title>Journal of pharmaceutical and biomedical analysis</title><addtitle>J Pharm Biomed Anal</addtitle><description>A flow-injection UV spectrophotometric method for the determination of ketoprofen in gels and ampules was developed. Quantitative determination of ketoprofen was realized by using distilled water as a carrier for gels and citrate buffer, pH 6.5, for ampules at 261
nm. No spectrophotometric interferences from additives of gels, carboxypolymethylene and triethanolamine, were observed. There were also no spectrophotometric interferences resulting from additives of ampules named as benzyl alcohol and arginine. The detection limits were 0.436 and 0.303
μg/ml for gels and ampules, respectively. Throughout the study, the flow rate, loop volume and the number of injection per hour were 13.8
ml
min
−1, 193
μl and 85, respectively. Analytical signal of the ketoprofen was linear in the concentration range of 7.5–75
μg/ml. Quantitative results of ketoprofen in gels, 25.25
±
0.27 (mean
±
S.D.), and in ampules, 99.42
±
0.44 were in good agreement with the labeled quantities (25
mg/1
g gel, 100
mg/2
ml ampule). The recoveries were in the range of 98.65–100.63 and 99.1–101.5% for gels and ampules, respectively.
Results obtained were in accordance with those obtained by HPLC. It was seen that the proposed method was fast, accurate, precise and suitable for automation as an analytical method.</description><subject>Acrylic Resins</subject><subject>Ampules</subject><subject>Analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - analysis</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - chemistry</subject><subject>Arginine - analysis</subject><subject>Benzyl Alcohols - analysis</subject><subject>Biological and medical sciences</subject><subject>Buffers</subject><subject>Calibration</subject><subject>Chemistry, Pharmaceutical - methods</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Chromatography, Thin Layer</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Stability</subject><subject>Ethanolamines - analysis</subject><subject>Flow-injection analysis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gels</subject><subject>General pharmacology</subject><subject>Hydrogen-Ion Concentration</subject><subject>Ketoprofen</subject><subject>Ketoprofen - analysis</subject><subject>Ketoprofen - chemistry</subject><subject>Medical sciences</subject><subject>Models, Chemical</subject><subject>Pharmacology. Drug treatments</subject><subject>Polyvinyls - analysis</subject><subject>Reproducibility of Results</subject><subject>Spectrophotometry</subject><subject>Spectrophotometry, Ultraviolet - methods</subject><subject>Tablets</subject><subject>Technology, Pharmaceutical - methods</subject><subject>Ultraviolet Rays</subject><subject>UV–vis spectrophotometry</subject><issn>0731-7085</issn><issn>1873-264X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUGP1CAYQInRuLOrf8CD4aK31g9aSifxYia6azKJmrjGG6H0Y6W2UKFdM_9eZmeSvXkCkve-wIOQVwxKBqx5N5TD3OmSA4gS6hKAPyEb1sqq4E398ynZgKxYIaEVF-QypQEyyLb1c3LBRLtttjVsSPy2ar-4RS_uHmmPC8bJ-XwKngZLf-MS5hgseuo8vcMxUe17qqd5HTHR7kDX5PwdtWP4Wzg_oHkwb3_QNOd9DPOvsIQJl3h4EG--7ncvyDOrx4Qvz-sVuf308fvupth_uf68-7AvTC1gKSyw2hpu-kpbITopRV9z4NryVspGV5ZBu2XAW9MzJlCyWmej6iTXTIPtqivy9jQ3P-DPimlRk0sGx1F7DGtSTSuA5R4Z5CfQxJBSRKvm6CYdD4qBOpZWgzqWVsfSCmqVS2fp9Xn62k3YPyrntBl4cwZ0Mnq0UXvj0iMnRf6qbZO59ycux8V7h1El49Ab7F3MCVUf3P_u8Q8W6J2X</recordid><startdate>20050915</startdate><enddate>20050915</enddate><creator>Özlü, Cihad</creator><creator>Basan, Hasan</creator><creator>Şatana, Eda</creator><creator>Ertaş, Nusret</creator><creator>Göğer, Nilgün G.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050915</creationdate><title>Quantitative determination of ketoprofen in gels and ampules by using flow-injection UV spectrophotometry and HPLC</title><author>Özlü, Cihad ; Basan, Hasan ; Şatana, Eda ; Ertaş, Nusret ; Göğer, Nilgün G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-f014fc2cd3af55b775d4202af28776a3f10891028cd115e714a0143b72a1a0fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acrylic Resins</topic><topic>Ampules</topic><topic>Analysis</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - analysis</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - chemistry</topic><topic>Arginine - analysis</topic><topic>Benzyl Alcohols - analysis</topic><topic>Biological and medical sciences</topic><topic>Buffers</topic><topic>Calibration</topic><topic>Chemistry, Pharmaceutical - methods</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Chromatography, Thin Layer</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Stability</topic><topic>Ethanolamines - analysis</topic><topic>Flow-injection analysis</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gels</topic><topic>General pharmacology</topic><topic>Hydrogen-Ion Concentration</topic><topic>Ketoprofen</topic><topic>Ketoprofen - analysis</topic><topic>Ketoprofen - chemistry</topic><topic>Medical sciences</topic><topic>Models, Chemical</topic><topic>Pharmacology. Drug treatments</topic><topic>Polyvinyls - analysis</topic><topic>Reproducibility of Results</topic><topic>Spectrophotometry</topic><topic>Spectrophotometry, Ultraviolet - methods</topic><topic>Tablets</topic><topic>Technology, Pharmaceutical - methods</topic><topic>Ultraviolet Rays</topic><topic>UV–vis spectrophotometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Özlü, Cihad</creatorcontrib><creatorcontrib>Basan, Hasan</creatorcontrib><creatorcontrib>Şatana, Eda</creatorcontrib><creatorcontrib>Ertaş, Nusret</creatorcontrib><creatorcontrib>Göğer, Nilgün G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Özlü, Cihad</au><au>Basan, Hasan</au><au>Şatana, Eda</au><au>Ertaş, Nusret</au><au>Göğer, Nilgün G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative determination of ketoprofen in gels and ampules by using flow-injection UV spectrophotometry and HPLC</atitle><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle><addtitle>J Pharm Biomed Anal</addtitle><date>2005-09-15</date><risdate>2005</risdate><volume>39</volume><issue>3</issue><spage>606</spage><epage>611</epage><pages>606-611</pages><issn>0731-7085</issn><eissn>1873-264X</eissn><coden>JPBADA</coden><abstract>A flow-injection UV spectrophotometric method for the determination of ketoprofen in gels and ampules was developed. Quantitative determination of ketoprofen was realized by using distilled water as a carrier for gels and citrate buffer, pH 6.5, for ampules at 261
nm. No spectrophotometric interferences from additives of gels, carboxypolymethylene and triethanolamine, were observed. There were also no spectrophotometric interferences resulting from additives of ampules named as benzyl alcohol and arginine. The detection limits were 0.436 and 0.303
μg/ml for gels and ampules, respectively. Throughout the study, the flow rate, loop volume and the number of injection per hour were 13.8
ml
min
−1, 193
μl and 85, respectively. Analytical signal of the ketoprofen was linear in the concentration range of 7.5–75
μg/ml. Quantitative results of ketoprofen in gels, 25.25
±
0.27 (mean
±
S.D.), and in ampules, 99.42
±
0.44 were in good agreement with the labeled quantities (25
mg/1
g gel, 100
mg/2
ml ampule). The recoveries were in the range of 98.65–100.63 and 99.1–101.5% for gels and ampules, respectively.
Results obtained were in accordance with those obtained by HPLC. It was seen that the proposed method was fast, accurate, precise and suitable for automation as an analytical method.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>15896940</pmid><doi>10.1016/j.jpba.2005.04.002</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0731-7085 |
| ispartof | Journal of pharmaceutical and biomedical analysis, 2005-09, Vol.39 (3), p.606-611 |
| issn | 0731-7085 1873-264X |
| language | eng |
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| subjects | Acrylic Resins Ampules Analysis Analytical, structural and metabolic biochemistry Anti-Inflammatory Agents, Non-Steroidal - analysis Anti-Inflammatory Agents, Non-Steroidal - chemistry Arginine - analysis Benzyl Alcohols - analysis Biological and medical sciences Buffers Calibration Chemistry, Pharmaceutical - methods Chromatography, High Pressure Liquid - methods Chromatography, Thin Layer Dose-Response Relationship, Drug Drug Stability Ethanolamines - analysis Flow-injection analysis Fundamental and applied biological sciences. Psychology Gels General pharmacology Hydrogen-Ion Concentration Ketoprofen Ketoprofen - analysis Ketoprofen - chemistry Medical sciences Models, Chemical Pharmacology. Drug treatments Polyvinyls - analysis Reproducibility of Results Spectrophotometry Spectrophotometry, Ultraviolet - methods Tablets Technology, Pharmaceutical - methods Ultraviolet Rays UV–vis spectrophotometry |
| title | Quantitative determination of ketoprofen in gels and ampules by using flow-injection UV spectrophotometry and HPLC |
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