Topography-biased compound library design: the shape of things to come?

The design and synthesis of quality compound libraries is of critical importance to any pharmaceutical company that relies on high throughput screening efforts for the identification of lead compounds. In this perspective, we use a moment of inertia derived shape analysis to interrogate potential li...

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Veröffentlicht in:	Drug discovery today 2007-11, Vol.12 (21), p.948-952
Hauptverfasser:	Akritopoulou-Zanze, Irini, Metz, James T., Djuric, Stevan W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry, Pharmaceutical Drug Design Molecular Conformation
Online-Zugang:	Volltext
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