The 2,5 oligoadenylate synthetase/RNaseL pathway is a novel effector of BRCA1- and interferon-γ-mediated apoptosis

BRCA1 has been reported to have roles in DNA damage repair, cell cycle checkpoint control, transcriptional regulation and ubiquitination. We have previously demonstrated that BRCA1 is a potent activator of a subset of interferon (IFN)-regulated genes and that BRCA1 synergistically activated a number...

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Veröffentlicht in:	Oncogene 2005-08, Vol.24 (35), p.5492-5501
Hauptverfasser:	Mullan, Paul B, Hosey, Alison M, Buckley, Niamh E, Quinn, Jennifer E, Kennedy, Richard D, Johnston, Patrick G, Harkin, D Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	2',5'-Oligoadenylate Synthetase - metabolism Apoptosis Apoptosis - physiology Blotting, Northern Blotting, Western BRCA1 protein BRCA1 Protein - metabolism Breast cancer Breast Neoplasms - enzymology Cell Biology Cell cycle Cell Line, Tumor DNA damage DNA repair DNA-Binding Proteins - metabolism Enzyme Activation - physiology Female Gene regulation Human Genetics Humans Interferon-gamma - metabolism Internal Medicine Medicine Medicine & Public Health Oncology original-paper Prostate Prostate cancer Signal Transduction - physiology Stat1 protein STAT1 Transcription Factor Trans-Activators - metabolism Transcription Transfection Tumor cell lines Tumor suppressor genes Tumors Ubiquitination γ-Interferon
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