CAML is a p56Lck-interacting protein that is required for thymocyte development

Calcium modulating cyclophilin ligand (CAML) is a ubiquitously expressed protein implicated in T cell signaling, although its mechanism and physiologic role in the immune system are unknown. We show here that CAML is essential for peripheral T cell development. Inactivation of CAML in mouse thymocyt...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2005-08, Vol.23 (2), p.139-152
Hauptverfasser:	Tran, David D, Edgar, Contessa E, Heckman, Karin L, Sutor, Shari L, Huntoon, Catherine J, van Deursen, Jan, McKean, David L, Bram, Richard J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - deficiency Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Adaptor Proteins, Signal Transducing - physiology Animals Apoptosis Apoptosis - physiology Cell Differentiation - genetics Cell Differentiation - immunology Efficiency Gene Transfer Techniques Humans Jurkat Cells Kinases Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - genetics Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - physiology Lymphocytes Mice Mice, Knockout Protein Structure, Tertiary Proteins Signal Transduction - genetics Signal Transduction - immunology T cell receptors T-Lymphocytes - cytology T-Lymphocytes - enzymology T-Lymphocytes - physiology Thymus Gland - cytology Thymus Gland - enzymology Thymus Gland - physiology
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