Imiquimod and S-27609 as adjuvants of DNA vaccination in a transgenic murine model of HER2/neu-positive mammary carcinoma

DNA vaccination against HER-2/neu is an effective way to induce an immune response able to oppose the spontaneous development of mammary tumours occurring in HER-2/neu transgenic mice. In this study, we have evaluated the potential of Imiquimod and the analogue S-27609 as adjuvants of DNA vaccinatio...

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Veröffentlicht in:	Gene therapy 2005-09, Vol.12 (17), p.1324-1332
Hauptverfasser:	Smorlesi, A, Papalini, F, Orlando, F, Donnini, A, Re, F, Provinciali, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants Adjuvants, Immunologic - administration & dosage Adoptive Transfer Aminoquinolines - administration & dosage Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animal models Animals Antiviral drugs Applied cell therapy and gene therapy Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotechnology Breast cancer Cancer Vaccines - administration & dosage Carcinoma Cell Biology Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cytotoxicity Deoxyribonucleic acid DNA DNA vaccines ErbB-2 protein Female Fundamental and applied biological sciences. Psychology Gene Expression Gene Therapy Genes, erbB-2 Genetic Therapy - methods Health. Pharmaceutical industry Human Genetics Imiquimod Immune response Immunoglobulin G Immunoregulation Industrial applications and implications. Economical aspects Interferon-gamma - immunology Interleukin 2 Interleukin 4 Interleukin-10 - immunology Interleukin-2 - immunology Lymphocytes T Mammary gland Mammary Neoplasms, Experimental - genetics Mammary Neoplasms, Experimental - immunology Mammary Neoplasms, Experimental - therapy Medical sciences Mice Mice, Transgenic Models, Animal Molecular and cellular biology Nanotechnology Phenotypes research-article Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transgenic animals Transgenic mice Tumors Vaccines Vaccines, DNA - administration & dosage γ-Interferon
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