Cellular hamartoma resembling gastrointestinal stromal tumor: a solid tumor of the pancreas expressing c-kit (CD117)
Solid tumors of the pancreas are usually neoplastic. We report on two adult patients, each with a solid tumor of the pancreas that presented with an unusual histology and seemed to follow a benign course. The tumors, one located in the body and one in the tail, were well demarcated and composed of i...
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| Veröffentlicht in: | Modern pathology 2005-09, Vol.18 (9), p.1211-1216 |
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| creator | Pauser, Ursula da Silva, Maria T S Placke, Jörg Klimstra, David S Klöppel, Günter |
| description | Solid tumors of the pancreas are usually neoplastic. We report on two adult patients, each with a solid tumor of the pancreas that presented with an unusual histology and seemed to follow a benign course. The tumors, one located in the body and one in the tail, were well demarcated and composed of irregularly arranged but well-differentiated acini and small intralobular and interlobular ducts embedded in predominantly hypocellular fibrotic tissue that contained fascicles of cytologically bland spindle cells. Islets were lacking, but immunohistochemical staining for chromogranin A and insulin revealed individual scattered insulin-producing cells distributed between acinar and ductal cells. The spindle cell component tissue showed coexpression of CD34, c-kit (CD117) and bcl-2. The follow-up (2 and 4 years) of the patients was uneventful. We propose to designate the tumors as ‘cellular hamartoma resembling gastrointestinal stromal tumor.' |
| doi_str_mv | 10.1038/modpathol.3800406 |
| format | Article |
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We report on two adult patients, each with a solid tumor of the pancreas that presented with an unusual histology and seemed to follow a benign course. The tumors, one located in the body and one in the tail, were well demarcated and composed of irregularly arranged but well-differentiated acini and small intralobular and interlobular ducts embedded in predominantly hypocellular fibrotic tissue that contained fascicles of cytologically bland spindle cells. Islets were lacking, but immunohistochemical staining for chromogranin A and insulin revealed individual scattered insulin-producing cells distributed between acinar and ductal cells. The spindle cell component tissue showed coexpression of CD34, c-kit (CD117) and bcl-2. The follow-up (2 and 4 years) of the patients was uneventful. We propose to designate the tumors as ‘cellular hamartoma resembling gastrointestinal stromal tumor.'</description><identifier>ISSN: 0893-3952</identifier><identifier>EISSN: 1530-0285</identifier><identifier>DOI: 10.1038/modpathol.3800406</identifier><identifier>PMID: 15803185</identifier><identifier>CODEN: MODPEO</identifier><language>eng</language><publisher>New York: Elsevier Inc</publisher><subject>Antigens, CD34 - metabolism ; bcl-2 ; c-kit ; CD34 ; differential diagnosis ; Female ; Gastrointestinal Stromal Tumors - metabolism ; Gastrointestinal Stromal Tumors - pathology ; hamartoma ; Hamartoma - metabolism ; Hamartoma - pathology ; Humans ; Immunohistochemistry ; Laboratory Medicine ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; original-article ; Pancreatic Diseases - metabolism ; Pancreatic Diseases - pathology ; pancreatic tumor ; Pathology ; Proto-Oncogene Proteins c-bcl-2 - metabolism ; Stem Cell Factor - metabolism</subject><ispartof>Modern pathology, 2005-09, Vol.18 (9), p.1211-1216</ispartof><rights>2005 United States & Canadian Academy of Pathology</rights><rights>United States and Canadian Academy of Pathology, Inc. 2005</rights><rights>Copyright Nature Publishing Group Sep 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c552t-607bfa91362565838a162a5080b50e973c8eb3ca7f6af5ea50e439bc40b65033</citedby><cites>FETCH-LOGICAL-c552t-607bfa91362565838a162a5080b50e973c8eb3ca7f6af5ea50e439bc40b65033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/221149278?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15803185$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pauser, Ursula</creatorcontrib><creatorcontrib>da Silva, Maria T S</creatorcontrib><creatorcontrib>Placke, Jörg</creatorcontrib><creatorcontrib>Klimstra, David S</creatorcontrib><creatorcontrib>Klöppel, Günter</creatorcontrib><title>Cellular hamartoma resembling gastrointestinal stromal tumor: a solid tumor of the pancreas expressing c-kit (CD117)</title><title>Modern pathology</title><addtitle>Mod Pathol</addtitle><addtitle>Mod Pathol</addtitle><description>Solid tumors of the pancreas are usually neoplastic. We report on two adult patients, each with a solid tumor of the pancreas that presented with an unusual histology and seemed to follow a benign course. The tumors, one located in the body and one in the tail, were well demarcated and composed of irregularly arranged but well-differentiated acini and small intralobular and interlobular ducts embedded in predominantly hypocellular fibrotic tissue that contained fascicles of cytologically bland spindle cells. Islets were lacking, but immunohistochemical staining for chromogranin A and insulin revealed individual scattered insulin-producing cells distributed between acinar and ductal cells. The spindle cell component tissue showed coexpression of CD34, c-kit (CD117) and bcl-2. The follow-up (2 and 4 years) of the patients was uneventful. 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We report on two adult patients, each with a solid tumor of the pancreas that presented with an unusual histology and seemed to follow a benign course. The tumors, one located in the body and one in the tail, were well demarcated and composed of irregularly arranged but well-differentiated acini and small intralobular and interlobular ducts embedded in predominantly hypocellular fibrotic tissue that contained fascicles of cytologically bland spindle cells. Islets were lacking, but immunohistochemical staining for chromogranin A and insulin revealed individual scattered insulin-producing cells distributed between acinar and ductal cells. The spindle cell component tissue showed coexpression of CD34, c-kit (CD117) and bcl-2. The follow-up (2 and 4 years) of the patients was uneventful. We propose to designate the tumors as ‘cellular hamartoma resembling gastrointestinal stromal tumor.'</abstract><cop>New York</cop><pub>Elsevier Inc</pub><pmid>15803185</pmid><doi>10.1038/modpathol.3800406</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antigens, CD34 - metabolism bcl-2 c-kit CD34 differential diagnosis Female Gastrointestinal Stromal Tumors - metabolism Gastrointestinal Stromal Tumors - pathology hamartoma Hamartoma - metabolism Hamartoma - pathology Humans Immunohistochemistry Laboratory Medicine Male Medicine Medicine & Public Health Middle Aged original-article Pancreatic Diseases - metabolism Pancreatic Diseases - pathology pancreatic tumor Pathology Proto-Oncogene Proteins c-bcl-2 - metabolism Stem Cell Factor - metabolism |
| title | Cellular hamartoma resembling gastrointestinal stromal tumor: a solid tumor of the pancreas expressing c-kit (CD117) |
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