Cell cycle, DNA replication, repair, and recombination in the dimorphic human pathogenic fungus Paracoccidioides brasiliensis
DNA replication, together with repair mechanisms and cell cycle control, are the most important cellular processes necessary to maintain correct transfer of genetic information to the progeny. These processes are well conserved throughout the Eukarya, and the genes that are involved provide essentia...
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| Veröffentlicht in: | Genetics and molecular research 2005-01, Vol.4 (2), p.232-250 |
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| creator | Reis, Viviane Castelo Branco Torres, Fernando Araripe Gonçalves Poças-Fonseca, Marcio José De-Souza, Marlene Teixeira Souza, Diorge Paulo de Almeida, João Ricardo Moreira Marinho-Silva, Camila Parachin, Nádia Skorupa Dantas, Alessandra da Silva Mello-de-Sousa, Thiago Machado Moraes, Lídia Maria Pepe de |
| description | DNA replication, together with repair mechanisms and cell cycle control, are the most important cellular processes necessary to maintain correct transfer of genetic information to the progeny. These processes are well conserved throughout the Eukarya, and the genes that are involved provide essential information for understanding the life cycle of an organism. We used computational tools for data mining of genes involved in these processes in the pathogenic fungus Paracoccidiodes brasiliensis. Data derived from transcriptome analysis revealed that the cell cycle of this fungus, as well as DNA replication and repair, and the recombination machineries, are highly similar to those of the yeast Saccharomyces cerevisiae. Among orthologs detected in both species, there are genes related to cytoskeleton structure and assembly, chromosome segregation, and cell cycle control genes. We identified at least one representative gene from each step of the initiation of DNA replication. Major players in the process of DNA damage and repair were also identified. |
| format | Article |
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| ispartof | Genetics and molecular research, 2005-01, Vol.4 (2), p.232-250 |
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| subjects | Cell Cycle - genetics Cell Cycle - physiology DNA Repair - genetics DNA Repair - physiology DNA Replication - genetics DNA Replication - physiology DNA, Fungal - genetics Genes, Fungal - genetics Humans Mutation - genetics Paracoccidioides - cytology Paracoccidioides - genetics Paracoccidioides brasiliensis Recombination, Genetic - genetics Recombination, Genetic - physiology Saccharomyces cerevisiae Transcription, Genetic - genetics |
| title | Cell cycle, DNA replication, repair, and recombination in the dimorphic human pathogenic fungus Paracoccidioides brasiliensis |
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