Oxycodone and morphine have distinctly different pharmacological profiles: Radioligand binding and behavioural studies in two rat models of neuropathic pain

Previously, we reported that oxycodone is a putative κ-opioid agonist based on studies where intracerebroventricular (i.c.v.) pre-treatment of rats with the κ-selective opioid antagonist, nor-binaltorphimine (nor-BNI), abolished i.c.v. oxycodone but not morphine antinociception, whereas pretreatment...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Pain (Amsterdam) 2007-12, Vol.132 (3), p.289-300
Hauptverfasser:	Nielsen, Carsten K., Ross, Fraser B., Lotfipour, Shahrdad, Saini, Kamal S., Edwards, Stephen R., Smith, Maree T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Animals Behavior, Animal - drug effects Behavior, Animal - physiology Biological and medical sciences Chronic constriction injury (CCI) Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction Disease Models, Animal Guinea Pigs Male Medical sciences Morphine Morphine - metabolism Morphine - pharmacology Morphine - therapeutic use Nervous system (semeiology, syndromes) Neuralgia - drug therapy Neuralgia - metabolism Neuralgia - psychology Neurology Neuropharmacology Oxycodone Oxycodone - metabolism Oxycodone - pharmacology Oxycodone - therapeutic use Pain - drug therapy Pain - metabolism Pain - psychology Pain Measurement - methods Painful diabetic neuropathy Pharmacology. Drug treatments Radioligand Assay - methods Radioligand binding Rats Rats, Sprague-Dawley Streptozotocin (STZ) κ 2-opioid receptors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!