Cleft Lip and Palate versus Cleft Lip Only: Are They Distinct Defects?
Cleft lip defects are usually regarded as a single entity, with the assumption that an accompanying cleft palate represents the more severe form. The authors linked data from the Medical Birth Registry of Norway with medical records from two centralized centers to provide a population-based data set...
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| Veröffentlicht in: | American journal of epidemiology 2005-09, Vol.162 (5), p.448-453 |
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| creator | Harville, Emily W. Wilcox, Allen J. Lie, Rolv Terje Vindenes, Hallvard Åbyholm, Frank |
| description | Cleft lip defects are usually regarded as a single entity, with the assumption that an accompanying cleft palate represents the more severe form. The authors linked data from the Medical Birth Registry of Norway with medical records from two centralized centers to provide a population-based data set. They assessed the distribution of cleft lip only and cleft lip with cleft palate by covariate. Among 1.8 million Norwegian livebirths between 1967 and 1998, there were 1,572 cases of cleft lip with cleft palate and 1,122 cases with cleft lip only. Seventeen percent of those with cleft lip and palate had another defect compared with 9% of those with cleft lip only. For boys, the risk was greater for cleft lip and palate than for cleft lip only (odds ratio = 2.4 vs. 1.8, p < 0.001 for difference). The risk of cleft lip only, but not of cleft lip and palate, was increased for twins (odds ratio = 1.6 vs. 1.1, p = 0.11) and infants whose parents were first cousins (odds ratio = 2.7 vs. 0.7, p = 0.07). Although cleft lip with cleft palate may simply represent a more severe form of the defect, epidemiologic assessments of cleft lip should, when possible, include separate analyses of these two groups. |
| doi_str_mv | 10.1093/aje/kwi214 |
| format | Article |
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The authors linked data from the Medical Birth Registry of Norway with medical records from two centralized centers to provide a population-based data set. They assessed the distribution of cleft lip only and cleft lip with cleft palate by covariate. Among 1.8 million Norwegian livebirths between 1967 and 1998, there were 1,572 cases of cleft lip with cleft palate and 1,122 cases with cleft lip only. Seventeen percent of those with cleft lip and palate had another defect compared with 9% of those with cleft lip only. For boys, the risk was greater for cleft lip and palate than for cleft lip only (odds ratio = 2.4 vs. 1.8, p < 0.001 for difference). The risk of cleft lip only, but not of cleft lip and palate, was increased for twins (odds ratio = 1.6 vs. 1.1, p = 0.11) and infants whose parents were first cousins (odds ratio = 2.7 vs. 0.7, p = 0.07). Although cleft lip with cleft palate may simply represent a more severe form of the defect, epidemiologic assessments of cleft lip should, when possible, include separate analyses of these two groups.</description><identifier>ISSN: 0002-9262</identifier><identifier>EISSN: 1476-6256</identifier><identifier>DOI: 10.1093/aje/kwi214</identifier><identifier>PMID: 16076837</identifier><identifier>CODEN: AJEPAS</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>abnormalities ; Abnormalities, Multiple - epidemiology ; Analysis. Health state ; Biological and medical sciences ; Birth defects ; Chi-Square Distribution ; cleft lip ; Cleft Lip - epidemiology ; cleft lip and palate ; cleft lip only ; cleft palate ; Cleft Palate - epidemiology ; CLO ; CLP ; Eighth Revision ; Epidemiology ; Facial bones, jaws, teeth, parodontium: diseases, semeiology ; Female ; General aspects ; Humans ; ICD-8 ; Infant, Newborn ; Infant, Premature ; International Classification of Diseases ; Logistic Models ; Male ; Medical sciences ; Mouth ; Non tumoral diseases ; Norway ; Norway - epidemiology ; Otorhinolaryngology. Stomatology ; Prevalence ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Registries ; Risk Factors</subject><ispartof>American journal of epidemiology, 2005-09, Vol.162 (5), p.448-453</ispartof><rights>2006 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Sep 1, 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-d02472cee6992e1698d3f565c0c9e4371a393f853bade898a2930526b01e7dce3</citedby><cites>FETCH-LOGICAL-c416t-d02472cee6992e1698d3f565c0c9e4371a393f853bade898a2930526b01e7dce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17433337$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16076837$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harville, Emily W.</creatorcontrib><creatorcontrib>Wilcox, Allen J.</creatorcontrib><creatorcontrib>Lie, Rolv Terje</creatorcontrib><creatorcontrib>Vindenes, Hallvard</creatorcontrib><creatorcontrib>Åbyholm, Frank</creatorcontrib><title>Cleft Lip and Palate versus Cleft Lip Only: Are They Distinct Defects?</title><title>American journal of epidemiology</title><addtitle>Am. J. Epidemiol</addtitle><description>Cleft lip defects are usually regarded as a single entity, with the assumption that an accompanying cleft palate represents the more severe form. The authors linked data from the Medical Birth Registry of Norway with medical records from two centralized centers to provide a population-based data set. They assessed the distribution of cleft lip only and cleft lip with cleft palate by covariate. Among 1.8 million Norwegian livebirths between 1967 and 1998, there were 1,572 cases of cleft lip with cleft palate and 1,122 cases with cleft lip only. Seventeen percent of those with cleft lip and palate had another defect compared with 9% of those with cleft lip only. For boys, the risk was greater for cleft lip and palate than for cleft lip only (odds ratio = 2.4 vs. 1.8, p < 0.001 for difference). The risk of cleft lip only, but not of cleft lip and palate, was increased for twins (odds ratio = 1.6 vs. 1.1, p = 0.11) and infants whose parents were first cousins (odds ratio = 2.7 vs. 0.7, p = 0.07). Although cleft lip with cleft palate may simply represent a more severe form of the defect, epidemiologic assessments of cleft lip should, when possible, include separate analyses of these two groups.</description><subject>abnormalities</subject><subject>Abnormalities, Multiple - epidemiology</subject><subject>Analysis. Health state</subject><subject>Biological and medical sciences</subject><subject>Birth defects</subject><subject>Chi-Square Distribution</subject><subject>cleft lip</subject><subject>Cleft Lip - epidemiology</subject><subject>cleft lip and palate</subject><subject>cleft lip only</subject><subject>cleft palate</subject><subject>Cleft Palate - epidemiology</subject><subject>CLO</subject><subject>CLP</subject><subject>Eighth Revision</subject><subject>Epidemiology</subject><subject>Facial bones, jaws, teeth, parodontium: diseases, semeiology</subject><subject>Female</subject><subject>General aspects</subject><subject>Humans</subject><subject>ICD-8</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>International Classification of Diseases</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mouth</subject><subject>Non tumoral diseases</subject><subject>Norway</subject><subject>Norway - epidemiology</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Prevalence</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Registries</subject><subject>Risk Factors</subject><issn>0002-9262</issn><issn>1476-6256</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0F1LwzAUBuAgis7pjT9AgqAXQjUfTdJ4I2PzCyZ-TRBvQpaeYmfXzqRV9--tbDjw3JyL8_ByeBHao-SEEs1P7QRO379yRuM11KGxkpFkQq6jDiGERZpJtoW2Q5gQQqkWZBNtUUmUTLjqoMt-AVmNh_kM2zLF97awNeBP8KEJeHW7K4v5Ge55wKM3mONBHuq8dDUeQAauDuc7aCOzRYDd5e6i58uLUf86Gt5d3fR7w8jFVNZRSlismAOQWjOgUicpz4QUjjgNMVfUcs2zRPCxTSHRiWWaE8HkmFBQqQPeRUeL3JmvPhoItZnmwUFR2BKqJhiZxFrQNqSLDv7BSdX4sv3NMC4SEpNEtuh4gZyvQvCQmZnPp9bPDSXmt1rTVmsW1bZ4f5nYjKeQruiyyxYcLoENzhaZt6XLw8qpmLfz66KFa0uE77-79e9GKq6EuX55NaOHp6tH9SjMLf8BCdmObw</recordid><startdate>20050901</startdate><enddate>20050901</enddate><creator>Harville, Emily W.</creator><creator>Wilcox, Allen J.</creator><creator>Lie, Rolv Terje</creator><creator>Vindenes, Hallvard</creator><creator>Åbyholm, Frank</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T2</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20050901</creationdate><title>Cleft Lip and Palate versus Cleft Lip Only: Are They Distinct Defects?</title><author>Harville, Emily W. ; Wilcox, Allen J. ; Lie, Rolv Terje ; Vindenes, Hallvard ; Åbyholm, Frank</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-d02472cee6992e1698d3f565c0c9e4371a393f853bade898a2930526b01e7dce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>abnormalities</topic><topic>Abnormalities, Multiple - epidemiology</topic><topic>Analysis. Health state</topic><topic>Biological and medical sciences</topic><topic>Birth defects</topic><topic>Chi-Square Distribution</topic><topic>cleft lip</topic><topic>Cleft Lip - epidemiology</topic><topic>cleft lip and palate</topic><topic>cleft lip only</topic><topic>cleft palate</topic><topic>Cleft Palate - epidemiology</topic><topic>CLO</topic><topic>CLP</topic><topic>Eighth Revision</topic><topic>Epidemiology</topic><topic>Facial bones, jaws, teeth, parodontium: diseases, semeiology</topic><topic>Female</topic><topic>General aspects</topic><topic>Humans</topic><topic>ICD-8</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>International Classification of Diseases</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mouth</topic><topic>Non tumoral diseases</topic><topic>Norway</topic><topic>Norway - epidemiology</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Prevalence</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Registries</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harville, Emily W.</creatorcontrib><creatorcontrib>Wilcox, Allen J.</creatorcontrib><creatorcontrib>Lie, Rolv Terje</creatorcontrib><creatorcontrib>Vindenes, Hallvard</creatorcontrib><creatorcontrib>Åbyholm, Frank</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harville, Emily W.</au><au>Wilcox, Allen J.</au><au>Lie, Rolv Terje</au><au>Vindenes, Hallvard</au><au>Åbyholm, Frank</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cleft Lip and Palate versus Cleft Lip Only: Are They Distinct Defects?</atitle><jtitle>American journal of epidemiology</jtitle><addtitle>Am. J. Epidemiol</addtitle><date>2005-09-01</date><risdate>2005</risdate><volume>162</volume><issue>5</issue><spage>448</spage><epage>453</epage><pages>448-453</pages><issn>0002-9262</issn><eissn>1476-6256</eissn><coden>AJEPAS</coden><abstract>Cleft lip defects are usually regarded as a single entity, with the assumption that an accompanying cleft palate represents the more severe form. The authors linked data from the Medical Birth Registry of Norway with medical records from two centralized centers to provide a population-based data set. They assessed the distribution of cleft lip only and cleft lip with cleft palate by covariate. Among 1.8 million Norwegian livebirths between 1967 and 1998, there were 1,572 cases of cleft lip with cleft palate and 1,122 cases with cleft lip only. Seventeen percent of those with cleft lip and palate had another defect compared with 9% of those with cleft lip only. For boys, the risk was greater for cleft lip and palate than for cleft lip only (odds ratio = 2.4 vs. 1.8, p < 0.001 for difference). The risk of cleft lip only, but not of cleft lip and palate, was increased for twins (odds ratio = 1.6 vs. 1.1, p = 0.11) and infants whose parents were first cousins (odds ratio = 2.7 vs. 0.7, p = 0.07). Although cleft lip with cleft palate may simply represent a more severe form of the defect, epidemiologic assessments of cleft lip should, when possible, include separate analyses of these two groups.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>16076837</pmid><doi>10.1093/aje/kwi214</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | abnormalities Abnormalities, Multiple - epidemiology Analysis. Health state Biological and medical sciences Birth defects Chi-Square Distribution cleft lip Cleft Lip - epidemiology cleft lip and palate cleft lip only cleft palate Cleft Palate - epidemiology CLO CLP Eighth Revision Epidemiology Facial bones, jaws, teeth, parodontium: diseases, semeiology Female General aspects Humans ICD-8 Infant, Newborn Infant, Premature International Classification of Diseases Logistic Models Male Medical sciences Mouth Non tumoral diseases Norway Norway - epidemiology Otorhinolaryngology. Stomatology Prevalence Public health. Hygiene Public health. Hygiene-occupational medicine Registries Risk Factors |
| title | Cleft Lip and Palate versus Cleft Lip Only: Are They Distinct Defects? |
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