Peptide hormones and histamine in plasma and synovial fluid of patients with rheumatoid arthritis and osteoarthrosis
Hormones other than adrenal and gonadal steroids may play also a significant role in the pathogenesis of rheumatoid arthritis. The aim of this study was to investigate the levels of selected peptide hormones and histamine in synovial fluid of knee joints and in plasma of patients with rheumatoid art...
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| Veröffentlicht in: | Endocrine regulations (Bratislava) 2005-01, Vol.39 (1), p.1-6 |
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| creator | Rovensky, J Imrich, R Radikova, Z Simorova, E Greguska, O Vigas, M Macho, L |
| description | Hormones other than adrenal and gonadal steroids may play also a significant role in the pathogenesis of rheumatoid arthritis. The aim of this study was to investigate the levels of selected peptide hormones and histamine in synovial fluid of knee joints and in plasma of patients with rheumatoid arthritis and with osteoarthrosis.
The concentrations of insulin, C-peptide, prolactin, growth hormone, free triiodothyronine (FT3), thyrotropin (TSH), and histamine were determined in synovial fluid and plasma of 27 patients with rheumatoid arthritis (RA) and in 12 patients with osteoarthrosis (OA).
The presence of peptide hormones in synovial fluid was demonstrated. The levels of TSH and growth hormone were lower in synovial fluid than in plasma in both groups, while those of prolactin were comparable in synovial fluid and in plasma. The levels of C-peptide (p < 0.05), insulin and FT3 were higher in synovial fluid than in plasma of OA patients, but lower in synovial fluid of RA patients as compared to their levels in plasma. Significant positive correlations between the levels in plasma and synovial fluid were observed in prolactin (p < 0.001, r = 0.741) and TSH (p < 0.05, r = 0.88) only. After age adjustment, no significant differences in synovial fluid and in plasma levels of all hormones were found between OA and RA patients. The levels of histamine in plasma were similar in RA and OA patients, in synovial fluid of both groups histamine was found in almost undetectable amounts.
The selected peptide hormones, e.g. insulin, C-peptide, prolactin, growth hormone, FT3 and TSH, are present in synovial fluid of RA and OA patients, some of them in the concentrations comparable to these in plasma. The role of the locally present hormones in pathogenesis of RA has to be investigated in further studies and analyses. |
| format | Article |
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The concentrations of insulin, C-peptide, prolactin, growth hormone, free triiodothyronine (FT3), thyrotropin (TSH), and histamine were determined in synovial fluid and plasma of 27 patients with rheumatoid arthritis (RA) and in 12 patients with osteoarthrosis (OA).
The presence of peptide hormones in synovial fluid was demonstrated. The levels of TSH and growth hormone were lower in synovial fluid than in plasma in both groups, while those of prolactin were comparable in synovial fluid and in plasma. The levels of C-peptide (p < 0.05), insulin and FT3 were higher in synovial fluid than in plasma of OA patients, but lower in synovial fluid of RA patients as compared to their levels in plasma. Significant positive correlations between the levels in plasma and synovial fluid were observed in prolactin (p < 0.001, r = 0.741) and TSH (p < 0.05, r = 0.88) only. After age adjustment, no significant differences in synovial fluid and in plasma levels of all hormones were found between OA and RA patients. The levels of histamine in plasma were similar in RA and OA patients, in synovial fluid of both groups histamine was found in almost undetectable amounts.
The selected peptide hormones, e.g. insulin, C-peptide, prolactin, growth hormone, FT3 and TSH, are present in synovial fluid of RA and OA patients, some of them in the concentrations comparable to these in plasma. The role of the locally present hormones in pathogenesis of RA has to be investigated in further studies and analyses.</description><identifier>ISSN: 1210-0668</identifier><identifier>PMID: 16107132</identifier><language>eng</language><publisher>Germany</publisher><subject>Arthritis, Rheumatoid - blood ; Arthritis, Rheumatoid - metabolism ; C-Peptide - analysis ; C-Peptide - blood ; Female ; Histamine - analysis ; Histamine - blood ; Human Growth Hormone - analysis ; Human Growth Hormone - blood ; Humans ; Insulin - analysis ; Insulin - blood ; Knee Joint ; Male ; Middle Aged ; Osteoarthritis - blood ; Osteoarthritis - metabolism ; Peptide Hormones - analysis ; Peptide Hormones - blood ; Prolactin - analysis ; Prolactin - blood ; Synovial Fluid - chemistry ; Thyrotropin - analysis ; Thyrotropin - blood ; Triiodothyronine - analysis ; Triiodothyronine - blood</subject><ispartof>Endocrine regulations (Bratislava), 2005-01, Vol.39 (1), p.1-6</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16107132$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rovensky, J</creatorcontrib><creatorcontrib>Imrich, R</creatorcontrib><creatorcontrib>Radikova, Z</creatorcontrib><creatorcontrib>Simorova, E</creatorcontrib><creatorcontrib>Greguska, O</creatorcontrib><creatorcontrib>Vigas, M</creatorcontrib><creatorcontrib>Macho, L</creatorcontrib><title>Peptide hormones and histamine in plasma and synovial fluid of patients with rheumatoid arthritis and osteoarthrosis</title><title>Endocrine regulations (Bratislava)</title><addtitle>Endocr Regul</addtitle><description>Hormones other than adrenal and gonadal steroids may play also a significant role in the pathogenesis of rheumatoid arthritis. The aim of this study was to investigate the levels of selected peptide hormones and histamine in synovial fluid of knee joints and in plasma of patients with rheumatoid arthritis and with osteoarthrosis.
The concentrations of insulin, C-peptide, prolactin, growth hormone, free triiodothyronine (FT3), thyrotropin (TSH), and histamine were determined in synovial fluid and plasma of 27 patients with rheumatoid arthritis (RA) and in 12 patients with osteoarthrosis (OA).
The presence of peptide hormones in synovial fluid was demonstrated. The levels of TSH and growth hormone were lower in synovial fluid than in plasma in both groups, while those of prolactin were comparable in synovial fluid and in plasma. The levels of C-peptide (p < 0.05), insulin and FT3 were higher in synovial fluid than in plasma of OA patients, but lower in synovial fluid of RA patients as compared to their levels in plasma. Significant positive correlations between the levels in plasma and synovial fluid were observed in prolactin (p < 0.001, r = 0.741) and TSH (p < 0.05, r = 0.88) only. After age adjustment, no significant differences in synovial fluid and in plasma levels of all hormones were found between OA and RA patients. The levels of histamine in plasma were similar in RA and OA patients, in synovial fluid of both groups histamine was found in almost undetectable amounts.
The selected peptide hormones, e.g. insulin, C-peptide, prolactin, growth hormone, FT3 and TSH, are present in synovial fluid of RA and OA patients, some of them in the concentrations comparable to these in plasma. The role of the locally present hormones in pathogenesis of RA has to be investigated in further studies and analyses.</description><subject>Arthritis, Rheumatoid - blood</subject><subject>Arthritis, Rheumatoid - metabolism</subject><subject>C-Peptide - analysis</subject><subject>C-Peptide - blood</subject><subject>Female</subject><subject>Histamine - analysis</subject><subject>Histamine - blood</subject><subject>Human Growth Hormone - analysis</subject><subject>Human Growth Hormone - blood</subject><subject>Humans</subject><subject>Insulin - analysis</subject><subject>Insulin - blood</subject><subject>Knee Joint</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Osteoarthritis - blood</subject><subject>Osteoarthritis - metabolism</subject><subject>Peptide Hormones - analysis</subject><subject>Peptide Hormones - blood</subject><subject>Prolactin - analysis</subject><subject>Prolactin - blood</subject><subject>Synovial Fluid - chemistry</subject><subject>Thyrotropin - analysis</subject><subject>Thyrotropin - blood</subject><subject>Triiodothyronine - analysis</subject><subject>Triiodothyronine - blood</subject><issn>1210-0668</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kE1LxDAYhHNQ3HX1L0hO3gpJm2aToyx-wYIe9Fzetm9opElqkir77y2762ngmWFg5oKseclZwaRUK3Kd0hdjpaqVvCIrLjnb8qpck_yOU7Y90iFEFzwmCr6ng00ZnPVIrafTCMnBkaeDDz8WRmrG2fY0GDpBtuhzor82DzQOODvIYfEg5iHabE-FIWUMRxSSTTfk0sCY8PasG_L59Pixeyn2b8-vu4d9MfFS5KJDoUVXm5aj6ngte6O1QMAtas60YaUxWJesVXqBoIB3qDQItQwTVSW6akPuT71TDN8zptw4mzocR_AY5tRIJXTNKrkE787BuXXYN1O0DuKh-f-p-gN-3GaZ</recordid><startdate>200501</startdate><enddate>200501</enddate><creator>Rovensky, J</creator><creator>Imrich, R</creator><creator>Radikova, Z</creator><creator>Simorova, E</creator><creator>Greguska, O</creator><creator>Vigas, M</creator><creator>Macho, L</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200501</creationdate><title>Peptide hormones and histamine in plasma and synovial fluid of patients with rheumatoid arthritis and osteoarthrosis</title><author>Rovensky, J ; Imrich, R ; Radikova, Z ; Simorova, E ; Greguska, O ; Vigas, M ; Macho, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p124t-ce494c5fb1e8c156df994eae7e9109f02ffe520b89eaea8a1ce89a481324334c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Arthritis, Rheumatoid - blood</topic><topic>Arthritis, Rheumatoid - metabolism</topic><topic>C-Peptide - analysis</topic><topic>C-Peptide - blood</topic><topic>Female</topic><topic>Histamine - analysis</topic><topic>Histamine - blood</topic><topic>Human Growth Hormone - analysis</topic><topic>Human Growth Hormone - blood</topic><topic>Humans</topic><topic>Insulin - analysis</topic><topic>Insulin - blood</topic><topic>Knee Joint</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Osteoarthritis - blood</topic><topic>Osteoarthritis - metabolism</topic><topic>Peptide Hormones - analysis</topic><topic>Peptide Hormones - blood</topic><topic>Prolactin - analysis</topic><topic>Prolactin - blood</topic><topic>Synovial Fluid - chemistry</topic><topic>Thyrotropin - analysis</topic><topic>Thyrotropin - blood</topic><topic>Triiodothyronine - analysis</topic><topic>Triiodothyronine - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rovensky, J</creatorcontrib><creatorcontrib>Imrich, R</creatorcontrib><creatorcontrib>Radikova, Z</creatorcontrib><creatorcontrib>Simorova, E</creatorcontrib><creatorcontrib>Greguska, O</creatorcontrib><creatorcontrib>Vigas, M</creatorcontrib><creatorcontrib>Macho, L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrine regulations (Bratislava)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rovensky, J</au><au>Imrich, R</au><au>Radikova, Z</au><au>Simorova, E</au><au>Greguska, O</au><au>Vigas, M</au><au>Macho, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peptide hormones and histamine in plasma and synovial fluid of patients with rheumatoid arthritis and osteoarthrosis</atitle><jtitle>Endocrine regulations (Bratislava)</jtitle><addtitle>Endocr Regul</addtitle><date>2005-01</date><risdate>2005</risdate><volume>39</volume><issue>1</issue><spage>1</spage><epage>6</epage><pages>1-6</pages><issn>1210-0668</issn><abstract>Hormones other than adrenal and gonadal steroids may play also a significant role in the pathogenesis of rheumatoid arthritis. The aim of this study was to investigate the levels of selected peptide hormones and histamine in synovial fluid of knee joints and in plasma of patients with rheumatoid arthritis and with osteoarthrosis.
The concentrations of insulin, C-peptide, prolactin, growth hormone, free triiodothyronine (FT3), thyrotropin (TSH), and histamine were determined in synovial fluid and plasma of 27 patients with rheumatoid arthritis (RA) and in 12 patients with osteoarthrosis (OA).
The presence of peptide hormones in synovial fluid was demonstrated. The levels of TSH and growth hormone were lower in synovial fluid than in plasma in both groups, while those of prolactin were comparable in synovial fluid and in plasma. The levels of C-peptide (p < 0.05), insulin and FT3 were higher in synovial fluid than in plasma of OA patients, but lower in synovial fluid of RA patients as compared to their levels in plasma. Significant positive correlations between the levels in plasma and synovial fluid were observed in prolactin (p < 0.001, r = 0.741) and TSH (p < 0.05, r = 0.88) only. After age adjustment, no significant differences in synovial fluid and in plasma levels of all hormones were found between OA and RA patients. The levels of histamine in plasma were similar in RA and OA patients, in synovial fluid of both groups histamine was found in almost undetectable amounts.
The selected peptide hormones, e.g. insulin, C-peptide, prolactin, growth hormone, FT3 and TSH, are present in synovial fluid of RA and OA patients, some of them in the concentrations comparable to these in plasma. The role of the locally present hormones in pathogenesis of RA has to be investigated in further studies and analyses.</abstract><cop>Germany</cop><pmid>16107132</pmid><tpages>6</tpages></addata></record> |
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| subjects | Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - metabolism C-Peptide - analysis C-Peptide - blood Female Histamine - analysis Histamine - blood Human Growth Hormone - analysis Human Growth Hormone - blood Humans Insulin - analysis Insulin - blood Knee Joint Male Middle Aged Osteoarthritis - blood Osteoarthritis - metabolism Peptide Hormones - analysis Peptide Hormones - blood Prolactin - analysis Prolactin - blood Synovial Fluid - chemistry Thyrotropin - analysis Thyrotropin - blood Triiodothyronine - analysis Triiodothyronine - blood |
| title | Peptide hormones and histamine in plasma and synovial fluid of patients with rheumatoid arthritis and osteoarthrosis |
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