IFN-gamma amplifies NFkappaB-dependent Neisseria meningitidis invasion of epithelial cells via specific upregulation of CEA-related cell adhesion molecule 1

Temporal relationship between viral and bacterial infections has been observed, and may arise via the action of virus-induced inflammatory cytokines. These, by upregulating epithelial receptors targeted by bacteria, may encourage greater bacterial infiltration. In this study, human epithelial cells...

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Veröffentlicht in:	Cellular microbiology 2007-12, Vol.9 (12), p.2968-2983
Hauptverfasser:	Griffiths, Natalie J, Bradley, Christopher J, Heyderman, Robert S, Virji, Mumtaz
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesins, Bacterial - physiology Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antigens, CD - biosynthesis Bacterial Adhesion Bacterial Outer Membrane Proteins - physiology Carrier Proteins - pharmacology Cell Adhesion Molecules - biosynthesis Cell Line Curcumin - pharmacology Epithelial Cells - microbiology Humans Interferon-gamma - antagonists & inhibitors Interferon-gamma - immunology Neisseria meningitidis - physiology NF-kappa B - physiology Peptide Fragments - pharmacology Peptides - pharmacology Up-Regulation Virus Diseases - immunology
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