The use of intranasal midazolam in the treatment of paediatric dental patients
Summary The aim of this study was to assess the use of intranasal midazolam in paediatric dental patients requiring extractions or simple surgical procedures who may otherwise have required a general anaesthetic. Twenty children aged between 2–9 years who required simple surgical procedures were giv...
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| Veröffentlicht in: | Anaesthesia 2007-12, Vol.62 (12), p.1262-1265 |
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| creator | Gilchrist, F. Cairns, A. M. Leitch, J. A. |
| description | Summary
The aim of this study was to assess the use of intranasal midazolam in paediatric dental patients requiring extractions or simple surgical procedures who may otherwise have required a general anaesthetic. Twenty children aged between 2–9 years who required simple surgical procedures were given 0.25 mg.kg−1 midazolam, administered using a MAD® (Mucosal Atomization Device; Wolfe Tory Medical Inc., Salt Lake City, UT, USA). Compliance with the full dose was achieved in 14 patients, 13 of whom completed the treatment. One of two patients who allowed only partial administration completed the treatment and three patients did not comply. The mean time to starting treatment was 13 min (range 6–25 min) and patients were discharged after a mean of 46 min (range 25–67 min). Physiological parameters remained stable throughout with no clinically significant episodes of desaturation. One patient vomited at home postoperatively. Midazolam in a dose of 0.25 mg.kg−1 administered intranasally provided adequate anxiolysis for the majority of children, allowing them to complete their treatment. |
| doi_str_mv | 10.1111/j.1365-2044.2007.05260.x |
| format | Article |
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The aim of this study was to assess the use of intranasal midazolam in paediatric dental patients requiring extractions or simple surgical procedures who may otherwise have required a general anaesthetic. Twenty children aged between 2–9 years who required simple surgical procedures were given 0.25 mg.kg−1 midazolam, administered using a MAD® (Mucosal Atomization Device; Wolfe Tory Medical Inc., Salt Lake City, UT, USA). Compliance with the full dose was achieved in 14 patients, 13 of whom completed the treatment. One of two patients who allowed only partial administration completed the treatment and three patients did not comply. The mean time to starting treatment was 13 min (range 6–25 min) and patients were discharged after a mean of 46 min (range 25–67 min). Physiological parameters remained stable throughout with no clinically significant episodes of desaturation. One patient vomited at home postoperatively. Midazolam in a dose of 0.25 mg.kg−1 administered intranasally provided adequate anxiolysis for the majority of children, allowing them to complete their treatment.</description><identifier>ISSN: 0003-2409</identifier><identifier>EISSN: 1365-2044</identifier><identifier>DOI: 10.1111/j.1365-2044.2007.05260.x</identifier><identifier>PMID: 17991264</identifier><identifier>CODEN: ANASAB</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Administration, Intranasal ; Anesthesia ; Anesthesia, Dental - instrumentation ; Anesthesia, Dental - methods ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Child ; Child, Preschool ; Conscious Sedation - instrumentation ; Conscious Sedation - methods ; Dental Care for Children - methods ; Dental research ; Drug dosages ; Female ; Humans ; Hypnotics and Sedatives - administration & dosage ; Male ; Medical sciences ; Midazolam - administration & dosage ; Nebulizers and Vaporizers ; Oral Surgical Procedures ; Pediatrics ; Pharmacology ; Tooth Extraction</subject><ispartof>Anaesthesia, 2007-12, Vol.62 (12), p.1262-1265</ispartof><rights>2008 INIST-CNRS</rights><rights>2007 The Authors Journal compilation 2007 The Association of Anaesthetists of Great Britain and Ireland</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4750-a3b48ad52508c5bdb1b523986da53e64026fdf6413df23c292e95014ea0bdaa13</citedby><cites>FETCH-LOGICAL-c4750-a3b48ad52508c5bdb1b523986da53e64026fdf6413df23c292e95014ea0bdaa13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2044.2007.05260.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2044.2007.05260.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,1428,27905,27906,45555,45556,46390,46814</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19866279$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17991264$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gilchrist, F.</creatorcontrib><creatorcontrib>Cairns, A. M.</creatorcontrib><creatorcontrib>Leitch, J. A.</creatorcontrib><title>The use of intranasal midazolam in the treatment of paediatric dental patients</title><title>Anaesthesia</title><addtitle>Anaesthesia</addtitle><description>Summary
The aim of this study was to assess the use of intranasal midazolam in paediatric dental patients requiring extractions or simple surgical procedures who may otherwise have required a general anaesthetic. Twenty children aged between 2–9 years who required simple surgical procedures were given 0.25 mg.kg−1 midazolam, administered using a MAD® (Mucosal Atomization Device; Wolfe Tory Medical Inc., Salt Lake City, UT, USA). Compliance with the full dose was achieved in 14 patients, 13 of whom completed the treatment. One of two patients who allowed only partial administration completed the treatment and three patients did not comply. The mean time to starting treatment was 13 min (range 6–25 min) and patients were discharged after a mean of 46 min (range 25–67 min). Physiological parameters remained stable throughout with no clinically significant episodes of desaturation. One patient vomited at home postoperatively. Midazolam in a dose of 0.25 mg.kg−1 administered intranasally provided adequate anxiolysis for the majority of children, allowing them to complete their treatment.</description><subject>Administration, Intranasal</subject><subject>Anesthesia</subject><subject>Anesthesia, Dental - instrumentation</subject><subject>Anesthesia, Dental - methods</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Conscious Sedation - instrumentation</subject><subject>Conscious Sedation - methods</subject><subject>Dental Care for Children - methods</subject><subject>Dental research</subject><subject>Drug dosages</subject><subject>Female</subject><subject>Humans</subject><subject>Hypnotics and Sedatives - administration & dosage</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Midazolam - administration & dosage</subject><subject>Nebulizers and Vaporizers</subject><subject>Oral Surgical Procedures</subject><subject>Pediatrics</subject><subject>Pharmacology</subject><subject>Tooth Extraction</subject><issn>0003-2409</issn><issn>1365-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtr3DAQgEVoaTab_oViAu3Nzuhp61JYQpoGwvaSnMXYkokWPzaSTZP--srdpYGcMpcZRt8Mo4-QjEJBU1zuCsqVzBkIUTCAsgDJFBTPJ2T1_-EDWQEAz5kAfUrOYtwBUFbR6hM5paXWlCmxItv7R5fN0WVjm_lhCjhgxC7rvcU_Y4d9amZTQqbgcOrdMC3gHp31OAXfZDa1Er_HyacqnpOPLXbRfT7mNXn4cX1_9TO_-3Vze7W5yxtRSsiR16JCK5mEqpG1rWktGdeVsii5UwKYam2rBOW2ZbxhmjktgQqHUFtEytfk22HvPoxPs4uT6X1sXNfh4MY5GlUJzZgsE3jxBtyNcxjSbYbqkkstKCSoOkBNGGMMrjX74HsML4aCWYSbnVm8msWrWYSbf8LNcxr9ctw_172zr4NHwwn4egQwNti1yXDj4yuXPq1YqRP3_cD99p17efcBZrPdXC8l_wtphprr</recordid><startdate>200712</startdate><enddate>200712</enddate><creator>Gilchrist, F.</creator><creator>Cairns, A. M.</creator><creator>Leitch, J. A.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200712</creationdate><title>The use of intranasal midazolam in the treatment of paediatric dental patients</title><author>Gilchrist, F. ; Cairns, A. M. ; Leitch, J. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4750-a3b48ad52508c5bdb1b523986da53e64026fdf6413df23c292e95014ea0bdaa13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Administration, Intranasal</topic><topic>Anesthesia</topic><topic>Anesthesia, Dental - instrumentation</topic><topic>Anesthesia, Dental - methods</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Conscious Sedation - instrumentation</topic><topic>Conscious Sedation - methods</topic><topic>Dental Care for Children - methods</topic><topic>Dental research</topic><topic>Drug dosages</topic><topic>Female</topic><topic>Humans</topic><topic>Hypnotics and Sedatives - administration & dosage</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Midazolam - administration & dosage</topic><topic>Nebulizers and Vaporizers</topic><topic>Oral Surgical Procedures</topic><topic>Pediatrics</topic><topic>Pharmacology</topic><topic>Tooth Extraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gilchrist, F.</creatorcontrib><creatorcontrib>Cairns, A. M.</creatorcontrib><creatorcontrib>Leitch, J. A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Anaesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gilchrist, F.</au><au>Cairns, A. M.</au><au>Leitch, J. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The use of intranasal midazolam in the treatment of paediatric dental patients</atitle><jtitle>Anaesthesia</jtitle><addtitle>Anaesthesia</addtitle><date>2007-12</date><risdate>2007</risdate><volume>62</volume><issue>12</issue><spage>1262</spage><epage>1265</epage><pages>1262-1265</pages><issn>0003-2409</issn><eissn>1365-2044</eissn><coden>ANASAB</coden><abstract>Summary
The aim of this study was to assess the use of intranasal midazolam in paediatric dental patients requiring extractions or simple surgical procedures who may otherwise have required a general anaesthetic. Twenty children aged between 2–9 years who required simple surgical procedures were given 0.25 mg.kg−1 midazolam, administered using a MAD® (Mucosal Atomization Device; Wolfe Tory Medical Inc., Salt Lake City, UT, USA). Compliance with the full dose was achieved in 14 patients, 13 of whom completed the treatment. One of two patients who allowed only partial administration completed the treatment and three patients did not comply. The mean time to starting treatment was 13 min (range 6–25 min) and patients were discharged after a mean of 46 min (range 25–67 min). Physiological parameters remained stable throughout with no clinically significant episodes of desaturation. One patient vomited at home postoperatively. Midazolam in a dose of 0.25 mg.kg−1 administered intranasally provided adequate anxiolysis for the majority of children, allowing them to complete their treatment.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17991264</pmid><doi>10.1111/j.1365-2044.2007.05260.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley-Blackwell Journals; MEDLINE; Wiley Journals Open Access; EZB Electronic Journals Library |
| subjects | Administration, Intranasal Anesthesia Anesthesia, Dental - instrumentation Anesthesia, Dental - methods Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Child Child, Preschool Conscious Sedation - instrumentation Conscious Sedation - methods Dental Care for Children - methods Dental research Drug dosages Female Humans Hypnotics and Sedatives - administration & dosage Male Medical sciences Midazolam - administration & dosage Nebulizers and Vaporizers Oral Surgical Procedures Pediatrics Pharmacology Tooth Extraction |
| title | The use of intranasal midazolam in the treatment of paediatric dental patients |
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