Stromelysin‐1 promoter 5A/6A polymorphism is an independent genetic prognostic risk factor and interacts with smoking cessation after index premature myocardial infarction

Objective: To evaluate the prognostic roles of multiple polymorphisms and smoking cessation for premature myocardial infarction (MI). Methods: We studied 170 patients with MI onset before the age of 45 years (range 27–45 years, 84% men) and analyzed the traditional risk factors and several candidate genes’ associations with their subsequent coronary events. Results: Follow‐up data were available for a total of 162 individuals (95.3%) with the other 38 individuals (4.7%) being lost‐to‐follow‐up premature MI patients. During a mean period of 4.43 years’ follow‐up, diabetes mellitus (DM), hypertension, hypercholesterolemia and Killip's status ≥II were more frequent among patients with subsequent cardiac events (all P‐values