The effect of hyoscine butylbromide on the first stage of labour in term pregnancies
Objective To determine whether hyoscine butylbromide shortens the first stage of labour, without an increase in maternal or neonatal complications. Design Randomised, double‐blinded, controlled trial. Setting The Antenatal clinics and Labour and Delivery ward of the University Hospital of the Wes...
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| Veröffentlicht in: | BJOG : an international journal of obstetrics and gynaecology 2007-12, Vol.114 (12), p.1542-1546 |
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| creator | Samuels, LA Christie, L Roberts‐Gittens, B Fletcher, H Frederick, J |
| description | Objective To determine whether hyoscine butylbromide shortens the first stage of labour, without an increase in maternal or neonatal complications.
Design Randomised, double‐blinded, controlled trial.
Setting The Antenatal clinics and Labour and Delivery ward of the University Hospital of the West Indies, Kingston, Jamaica.
Population Women in spontaneous labour at term.
Methods Either drug or placebo was given intravenously once the women entered active labour.
Main outcome measures The duration of the first stage of labour. Secondary outcomes included comparisons of the duration of the second and third stages of labour, blood loss at delivery, rate of caesarean section, and APGAR scores in the neonates between the two groups.
Results A total of 129 women yielded data for analysis. Of these, 69 women received the placebo and 60 received hyoscine butylbromide. The mean time for the first stage in the control group was 228 minutes, compared with 156 minutes in the drug group, representing a decrease of 31.7% (P = 0.001). There was no significant change in the duration of the second and third stages of labour, and no difference in blood loss or in APGAR scores. There was a slight (but statistically insignificant) increase in the caesarean section rate.
Conclusion Hyoscine butylbromide is effective in significantly reducing the duration of the first stage of labour, and it is not associated with any obvious adverse outcomes in mother or neonate. |
| doi_str_mv | 10.1111/j.1471-0528.2007.01497.x |
| format | Article |
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Design Randomised, double‐blinded, controlled trial.
Setting The Antenatal clinics and Labour and Delivery ward of the University Hospital of the West Indies, Kingston, Jamaica.
Population Women in spontaneous labour at term.
Methods Either drug or placebo was given intravenously once the women entered active labour.
Main outcome measures The duration of the first stage of labour. Secondary outcomes included comparisons of the duration of the second and third stages of labour, blood loss at delivery, rate of caesarean section, and APGAR scores in the neonates between the two groups.
Results A total of 129 women yielded data for analysis. Of these, 69 women received the placebo and 60 received hyoscine butylbromide. The mean time for the first stage in the control group was 228 minutes, compared with 156 minutes in the drug group, representing a decrease of 31.7% (P = 0.001). There was no significant change in the duration of the second and third stages of labour, and no difference in blood loss or in APGAR scores. There was a slight (but statistically insignificant) increase in the caesarean section rate.
Conclusion Hyoscine butylbromide is effective in significantly reducing the duration of the first stage of labour, and it is not associated with any obvious adverse outcomes in mother or neonate.</description><identifier>ISSN: 1470-0328</identifier><identifier>EISSN: 1471-0528</identifier><identifier>DOI: 10.1111/j.1471-0528.2007.01497.x</identifier><identifier>PMID: 17903230</identifier><identifier>CODEN: BIOGFQ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Apgar Score ; Biological and medical sciences ; Buscopan ; Butylscopolammonium Bromide - therapeutic use ; Cesarean Section - statistics & numerical data ; Childbirth & labor ; Clinical outcomes ; Clinical trials ; Double-Blind Method ; Drug therapy ; Female ; first stage ; Gynecology. Andrology. Obstetrics ; Humans ; Hyoscine ; Labor Stage, First - drug effects ; Labor, Induced - methods ; labour ; Medical sciences ; Obstetrics ; Parasympatholytics - therapeutic use ; Postpartum Hemorrhage - chemically induced ; Pregnancy ; Pregnancy Outcome ; shortens ; Time Factors</subject><ispartof>BJOG : an international journal of obstetrics and gynaecology, 2007-12, Vol.114 (12), p.1542-1546</ispartof><rights>RCOG 2007 BJOG An International Journal of Obstetrics and Gynaecology</rights><rights>2008 INIST-CNRS</rights><rights>2007 The Authors Journal compilation</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4247-1a8d85c578d6000a7a07dab9c13362f8ce4de04fdeaa7c8276c5ec5b8031baf73</citedby><cites>FETCH-LOGICAL-c4247-1a8d85c578d6000a7a07dab9c13362f8ce4de04fdeaa7c8276c5ec5b8031baf73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1471-0528.2007.01497.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1471-0528.2007.01497.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19438441$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17903230$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Samuels, LA</creatorcontrib><creatorcontrib>Christie, L</creatorcontrib><creatorcontrib>Roberts‐Gittens, B</creatorcontrib><creatorcontrib>Fletcher, H</creatorcontrib><creatorcontrib>Frederick, J</creatorcontrib><title>The effect of hyoscine butylbromide on the first stage of labour in term pregnancies</title><title>BJOG : an international journal of obstetrics and gynaecology</title><addtitle>BJOG</addtitle><description>Objective To determine whether hyoscine butylbromide shortens the first stage of labour, without an increase in maternal or neonatal complications.
Design Randomised, double‐blinded, controlled trial.
Setting The Antenatal clinics and Labour and Delivery ward of the University Hospital of the West Indies, Kingston, Jamaica.
Population Women in spontaneous labour at term.
Methods Either drug or placebo was given intravenously once the women entered active labour.
Main outcome measures The duration of the first stage of labour. Secondary outcomes included comparisons of the duration of the second and third stages of labour, blood loss at delivery, rate of caesarean section, and APGAR scores in the neonates between the two groups.
Results A total of 129 women yielded data for analysis. Of these, 69 women received the placebo and 60 received hyoscine butylbromide. The mean time for the first stage in the control group was 228 minutes, compared with 156 minutes in the drug group, representing a decrease of 31.7% (P = 0.001). There was no significant change in the duration of the second and third stages of labour, and no difference in blood loss or in APGAR scores. There was a slight (but statistically insignificant) increase in the caesarean section rate.
Conclusion Hyoscine butylbromide is effective in significantly reducing the duration of the first stage of labour, and it is not associated with any obvious adverse outcomes in mother or neonate.</description><subject>Apgar Score</subject><subject>Biological and medical sciences</subject><subject>Buscopan</subject><subject>Butylscopolammonium Bromide - therapeutic use</subject><subject>Cesarean Section - statistics & numerical data</subject><subject>Childbirth & labor</subject><subject>Clinical outcomes</subject><subject>Clinical trials</subject><subject>Double-Blind Method</subject><subject>Drug therapy</subject><subject>Female</subject><subject>first stage</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Hyoscine</subject><subject>Labor Stage, First - drug effects</subject><subject>Labor, Induced - methods</subject><subject>labour</subject><subject>Medical sciences</subject><subject>Obstetrics</subject><subject>Parasympatholytics - therapeutic use</subject><subject>Postpartum Hemorrhage - chemically induced</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>shortens</subject><subject>Time Factors</subject><issn>1470-0328</issn><issn>1471-0528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1P3DAQhq0KVL76FyoLqb0ljD8SO4ceWlSgFRKX5Ww5zhiyysdiJyr773HYFUg94YtHM8-MXj2EUAY5S-9inTOpWAYF1zkHUDkwWan8-RM5fhscvNaQgeD6iJzEuAZgJQfxmRwxVaW2gGOyWj0iRe_RTXT09HE7RtcOSOt52nZ1GPu2QToOdEqYb0OcaJzsAy5sZ-txDrRNQww93QR8GOzgWoxn5NDbLuKX_X9K7q9-ry5vstu76z-XP28zJ7lUGbO60YUrlG5KALDKgmpsXTkmRMm9digbBOkbtFY5zVXpCnRFrUGw2nolTsn33d1NGJ9mjJPp2-iw6-yA4xxNqaWudLWA5_-B6xR9SNkM50UJBVRlgvQOcmGMMaA3m9D2NmwNA7NoN2uz2DWLXbNoN6_azXNa_bq_P9c9Nu-Le88J-LYHbHS282ERFd-5SgotJUvcjx33r-1w--EA5tffu6USL6mYnWs</recordid><startdate>200712</startdate><enddate>200712</enddate><creator>Samuels, LA</creator><creator>Christie, L</creator><creator>Roberts‐Gittens, B</creator><creator>Fletcher, H</creator><creator>Frederick, J</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200712</creationdate><title>The effect of hyoscine butylbromide on the first stage of labour in term pregnancies</title><author>Samuels, LA ; Christie, L ; Roberts‐Gittens, B ; Fletcher, H ; Frederick, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4247-1a8d85c578d6000a7a07dab9c13362f8ce4de04fdeaa7c8276c5ec5b8031baf73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Apgar Score</topic><topic>Biological and medical sciences</topic><topic>Buscopan</topic><topic>Butylscopolammonium Bromide - therapeutic use</topic><topic>Cesarean Section - statistics & numerical data</topic><topic>Childbirth & labor</topic><topic>Clinical outcomes</topic><topic>Clinical trials</topic><topic>Double-Blind Method</topic><topic>Drug therapy</topic><topic>Female</topic><topic>first stage</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Hyoscine</topic><topic>Labor Stage, First - drug effects</topic><topic>Labor, Induced - methods</topic><topic>labour</topic><topic>Medical sciences</topic><topic>Obstetrics</topic><topic>Parasympatholytics - therapeutic use</topic><topic>Postpartum Hemorrhage - chemically induced</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>shortens</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Samuels, LA</creatorcontrib><creatorcontrib>Christie, L</creatorcontrib><creatorcontrib>Roberts‐Gittens, B</creatorcontrib><creatorcontrib>Fletcher, H</creatorcontrib><creatorcontrib>Frederick, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Samuels, LA</au><au>Christie, L</au><au>Roberts‐Gittens, B</au><au>Fletcher, H</au><au>Frederick, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of hyoscine butylbromide on the first stage of labour in term pregnancies</atitle><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle><addtitle>BJOG</addtitle><date>2007-12</date><risdate>2007</risdate><volume>114</volume><issue>12</issue><spage>1542</spage><epage>1546</epage><pages>1542-1546</pages><issn>1470-0328</issn><eissn>1471-0528</eissn><coden>BIOGFQ</coden><abstract>Objective To determine whether hyoscine butylbromide shortens the first stage of labour, without an increase in maternal or neonatal complications.
Design Randomised, double‐blinded, controlled trial.
Setting The Antenatal clinics and Labour and Delivery ward of the University Hospital of the West Indies, Kingston, Jamaica.
Population Women in spontaneous labour at term.
Methods Either drug or placebo was given intravenously once the women entered active labour.
Main outcome measures The duration of the first stage of labour. Secondary outcomes included comparisons of the duration of the second and third stages of labour, blood loss at delivery, rate of caesarean section, and APGAR scores in the neonates between the two groups.
Results A total of 129 women yielded data for analysis. Of these, 69 women received the placebo and 60 received hyoscine butylbromide. The mean time for the first stage in the control group was 228 minutes, compared with 156 minutes in the drug group, representing a decrease of 31.7% (P = 0.001). There was no significant change in the duration of the second and third stages of labour, and no difference in blood loss or in APGAR scores. There was a slight (but statistically insignificant) increase in the caesarean section rate.
Conclusion Hyoscine butylbromide is effective in significantly reducing the duration of the first stage of labour, and it is not associated with any obvious adverse outcomes in mother or neonate.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17903230</pmid><doi>10.1111/j.1471-0528.2007.01497.x</doi><tpages>5</tpages></addata></record> |
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| issn | 1470-0328 1471-0528 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals |
| subjects | Apgar Score Biological and medical sciences Buscopan Butylscopolammonium Bromide - therapeutic use Cesarean Section - statistics & numerical data Childbirth & labor Clinical outcomes Clinical trials Double-Blind Method Drug therapy Female first stage Gynecology. Andrology. Obstetrics Humans Hyoscine Labor Stage, First - drug effects Labor, Induced - methods labour Medical sciences Obstetrics Parasympatholytics - therapeutic use Postpartum Hemorrhage - chemically induced Pregnancy Pregnancy Outcome shortens Time Factors |
| title | The effect of hyoscine butylbromide on the first stage of labour in term pregnancies |
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