Functional significance of vascular endothelial growth factor receptors on gastrointestinal cancer cells

Vascular endothelial growth factor (VEGF) has been shown to be the major mediator of physiologic and pathologic angiogenesis. VEGF was initially thought to be an endothelial cell specific ligand, but recently, VEGF has been shown to mediate tumor cell function via activation of receptors on tumor ce...

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Veröffentlicht in:	Cancer and metastasis reviews 2007-12, Vol.26 (3-4), p.433-441, Article 433
Hauptverfasser:	Dallas, Nikolaos A, Fan, Fan, Gray, Michael J, Van Buren, 2nd, George, Lim, Sherry J, Xia, Ling, Ellis, Lee M
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Cell activation Colorectal cancer Colorectal Neoplasms - blood supply Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology Endothelial cells Gastric cancer Gastrointestinal Neoplasms - blood supply Gastrointestinal Neoplasms - drug therapy Gastrointestinal Neoplasms - pathology Growth factor receptors Humans Neuropilin-1 - analysis Neuropilin-1 - physiology Pancreatic cancer Pancreatic Neoplasms - blood supply Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - pathology Receptor mechanisms Receptors, Vascular Endothelial Growth Factor - analysis Receptors, Vascular Endothelial Growth Factor - physiology Tumor cells Vascular endothelial growth factor Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular Endothelial Growth Factor A - physiology Vascular endothelial growth factor receptors
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