Thyroxine (T4 ) transfer from CSF to choroid plexus and ventricular brain regions in rabbit: Contributory role of P-glycoprotein and organic anion transporting polypeptides

Abstract This study investigated the transfer of T4 from cerebrospinal fluid (CSF) into the choroid plexuses (CP) and ventricular brain regions, and the role of P-glycoprotein (P-gp), multidrug resistance protein 1 (mrp1) and organic anion transporting polypeptides (oatps). During in vivo ventriculo...

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Veröffentlicht in:	Brain research 2007-11, Vol.1181, p.44-50
Hauptverfasser:	Kassem, Nouhad A, Deane, Rashid, Segal, Malcolm B, Chen, RuoLi, Preston, Jane E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP-Binding Cassette, Sub-Family B, Member 1 - physiology Biological and medical sciences Blood–brain barrier Blood–CSF barrier Brain - blood supply Brain - metabolism Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Cerebral Ventricles - blood supply Cerebral Ventricles - metabolism Cerebrovascular Circulation - physiology Choroid plexus Choroid Plexus - metabolism Female Fundamental and applied biological sciences. Psychology In Vitro Techniques Male mrp1 Multidrug Resistance-Associated Proteins - physiology Neurology Organic Anion Transporters - physiology P-gp Rabbits Statistics, Nonparametric Thyroxine - blood Thyroxine - cerebrospinal fluid Thyroxine - metabolism Vertebrates: nervous system and sense organs
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