Cell Penetrating Agents Based on a Polyproline Helix Scaffold

Cell penetrating agents were designed and synthesized that introduce cationic and hydrophobic moieties along the backbone of a polyproline helix (PPII) in an amphiphilic manner. The CD profile has the features that are expected for a PPII helix, demonstrating that the addition of these groups had li...

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Veröffentlicht in:	Journal of the American Chemical Society 2005-08, Vol.127 (33), p.11798-11803
Hauptverfasser:	Fillon, Yannick A, Anderson, Jason P, Chmielewski, Jean
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Breast Neoplasms - metabolism Cell Membrane - drug effects Cell Membrane - metabolism Cell Proliferation - drug effects Crystallography, X-Ray Drug Carriers - chemical synthesis Drug Carriers - chemistry Drug Carriers - pharmacokinetics Drug Delivery Systems Female Flow Cytometry Fundamental and applied biological sciences. Psychology Humans Models, Molecular Molecular and cellular biology Molecular Conformation Molecular genetics Peptides - chemistry Protein Structure, Secondary Transcription. Transcription factor. Splicing. Rna processing
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