Impact of the CYP2D6 genotype on steady-state serum concentrations of aripiprazole and dehydroaripiprazole

Aripiprazole is an atypical antipsychotic drug which is metabolized by the polymorphic enzyme cytochrome P450 2D6 (CYP2D6). The aim of the present study was to investigate the impact of the CYP2D6 genotype on serum concentrations of aripiprazole (ARI) and to determine the sum of ARI and the active m...

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Veröffentlicht in:	European journal of clinical pharmacology 2007-12, Vol.63 (12), p.1147-1151
Hauptverfasser:	HENDSET, Magnhild, HERMANN, Monica, LUNDE, Hilde, REFSUM, Helge, MOLDEN, Espen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Antipsychotic Agents - blood Aripiprazole Biological and medical sciences Cellular biology Cytochrome P-450 CYP2D6 - genetics Drug dosages Drug Monitoring - methods Enzymes Female Genotype Genotype & phenotype Humans Male Medical sciences Middle Aged Pharmacogenetics Pharmacology Pharmacology. Drug treatments Piperazines - blood Psychotropic drugs Quinolones - blood Retrospective Studies
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