In-situ preparation of poly(propylene fumarate)—hydroxyapatite composite
In-situ precipitation of hydroxyapatite (HAp) in the presence of poly(propylene fumarate) (PPF) is investigated. Amorphous calcium phosphate (ACP) precipitates in the presence of the polymer and remains in the amorphous form for a relatively long time, e.g. even after 24 h of coexistence with the mo...
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| Veröffentlicht in: | Biomaterials 2005-12, Vol.26 (35), p.7297-7303 |
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| creator | Hakimimehr, Dorna Liu, Dean-Mo Troczynski, Tom |
| description | In-situ precipitation of hydroxyapatite (HAp) in the presence of poly(propylene fumarate) (PPF) is investigated. Amorphous calcium phosphate (ACP) precipitates in the presence of the polymer and remains in the amorphous form for a relatively long time, e.g. even after 24
h of coexistence with the mother solution. Our observations suggest that PPF interacts with the surface of the ACP particles and prevents them from transformation to crystalline hydroxyapatite. The PPF polymer seems to be more efficient in hindering the ACP to HAp transformation at higher pH conditions. From spectroscopic observations we hypothesize that the C
O bond of the PPF molecules interact with the calcium ion of the ACP particles. In case of low molecular weight PPF this interaction may lead to the incorporation of the polymer within the growing ACP particles. |
| doi_str_mv | 10.1016/j.biomaterials.2005.05.065 |
| format | Article |
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h of coexistence with the mother solution. Our observations suggest that PPF interacts with the surface of the ACP particles and prevents them from transformation to crystalline hydroxyapatite. The PPF polymer seems to be more efficient in hindering the ACP to HAp transformation at higher pH conditions. From spectroscopic observations we hypothesize that the C
O bond of the PPF molecules interact with the calcium ion of the ACP particles. In case of low molecular weight PPF this interaction may lead to the incorporation of the polymer within the growing ACP particles.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/j.biomaterials.2005.05.065</identifier><identifier>PMID: 16026822</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Amorphous calcium phosphate ; Biocompatible Materials - chemistry ; Calcium Phosphates ; Chemical Precipitation ; Composite ; Crystallization - methods ; Durapatite - analysis ; Durapatite - chemistry ; Fumarates - analysis ; Fumarates - chemistry ; Hydrogen-Ion Concentration ; In-situ synthesis ; Materials Testing ; Molecular Conformation ; Molecular Weight ; Poly(propylene fumarate) ; Polypropylenes - analysis ; Polypropylenes - chemistry</subject><ispartof>Biomaterials, 2005-12, Vol.26 (35), p.7297-7303</ispartof><rights>2005 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-7f5bd2c89ed3f86d85b0e47a67d20d19ff4867c8ec2865743ceff1a74184065e3</citedby><cites>FETCH-LOGICAL-c506t-7f5bd2c89ed3f86d85b0e47a67d20d19ff4867c8ec2865743ceff1a74184065e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biomaterials.2005.05.065$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16026822$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hakimimehr, Dorna</creatorcontrib><creatorcontrib>Liu, Dean-Mo</creatorcontrib><creatorcontrib>Troczynski, Tom</creatorcontrib><title>In-situ preparation of poly(propylene fumarate)—hydroxyapatite composite</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>In-situ precipitation of hydroxyapatite (HAp) in the presence of poly(propylene fumarate) (PPF) is investigated. Amorphous calcium phosphate (ACP) precipitates in the presence of the polymer and remains in the amorphous form for a relatively long time, e.g. even after 24
h of coexistence with the mother solution. Our observations suggest that PPF interacts with the surface of the ACP particles and prevents them from transformation to crystalline hydroxyapatite. The PPF polymer seems to be more efficient in hindering the ACP to HAp transformation at higher pH conditions. From spectroscopic observations we hypothesize that the C
O bond of the PPF molecules interact with the calcium ion of the ACP particles. In case of low molecular weight PPF this interaction may lead to the incorporation of the polymer within the growing ACP particles.</description><subject>Amorphous calcium phosphate</subject><subject>Biocompatible Materials - chemistry</subject><subject>Calcium Phosphates</subject><subject>Chemical Precipitation</subject><subject>Composite</subject><subject>Crystallization - methods</subject><subject>Durapatite - analysis</subject><subject>Durapatite - chemistry</subject><subject>Fumarates - analysis</subject><subject>Fumarates - chemistry</subject><subject>Hydrogen-Ion Concentration</subject><subject>In-situ synthesis</subject><subject>Materials Testing</subject><subject>Molecular Conformation</subject><subject>Molecular Weight</subject><subject>Poly(propylene fumarate)</subject><subject>Polypropylenes - analysis</subject><subject>Polypropylenes - chemistry</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1KxDAUhYMoOv68ghQXoouOSdqkGXcy_iO40XXoJDeYoW1q0ord-RA-oU9iygzoTuFCCPnuOTf3IHRE8JRgws-W04V1ddmBt2UVphRjNh2Lsw00IaIQKZthtokmmOQ0nXFCd9BuCEsc7zin22iHcEy5oHSC7u-aNNiuT1oPbenLzromcSZpXTWctN61QwUNJKavx0c4_fr4fBm0d-9D2Ua4g0S5unVRAvbRlonzwMH63EPP11dP89v04fHmbn7xkCqGeZcWhi00VWIGOjOCa8EWGPKi5IWmWJOZMbnghRKgqOCsyDMFxpCyyInI4xch20PHK9043msPoZO1DQqqqmzA9UFyEQUyRv8EqSgygnPxD5CJaM8ieL4ClXcheDCy9TZuZpAEyzEbuZS_s5FjNnIsPjYfrl36RQ36p3UdRgQuVwDE7b1Z8DIoC40CbT2oTmpn_-PzDcNOqPY</recordid><startdate>20051201</startdate><enddate>20051201</enddate><creator>Hakimimehr, Dorna</creator><creator>Liu, Dean-Mo</creator><creator>Troczynski, Tom</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope><scope>7QQ</scope><scope>7X8</scope></search><sort><creationdate>20051201</creationdate><title>In-situ preparation of poly(propylene fumarate)—hydroxyapatite composite</title><author>Hakimimehr, Dorna ; Liu, Dean-Mo ; Troczynski, Tom</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-7f5bd2c89ed3f86d85b0e47a67d20d19ff4867c8ec2865743ceff1a74184065e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Amorphous calcium phosphate</topic><topic>Biocompatible Materials - chemistry</topic><topic>Calcium Phosphates</topic><topic>Chemical Precipitation</topic><topic>Composite</topic><topic>Crystallization - methods</topic><topic>Durapatite - analysis</topic><topic>Durapatite - chemistry</topic><topic>Fumarates - analysis</topic><topic>Fumarates - chemistry</topic><topic>Hydrogen-Ion Concentration</topic><topic>In-situ synthesis</topic><topic>Materials Testing</topic><topic>Molecular Conformation</topic><topic>Molecular Weight</topic><topic>Poly(propylene fumarate)</topic><topic>Polypropylenes - analysis</topic><topic>Polypropylenes - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hakimimehr, Dorna</creatorcontrib><creatorcontrib>Liu, Dean-Mo</creatorcontrib><creatorcontrib>Troczynski, Tom</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Ceramic Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hakimimehr, Dorna</au><au>Liu, Dean-Mo</au><au>Troczynski, Tom</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In-situ preparation of poly(propylene fumarate)—hydroxyapatite composite</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>2005-12-01</date><risdate>2005</risdate><volume>26</volume><issue>35</issue><spage>7297</spage><epage>7303</epage><pages>7297-7303</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>In-situ precipitation of hydroxyapatite (HAp) in the presence of poly(propylene fumarate) (PPF) is investigated. Amorphous calcium phosphate (ACP) precipitates in the presence of the polymer and remains in the amorphous form for a relatively long time, e.g. even after 24
h of coexistence with the mother solution. Our observations suggest that PPF interacts with the surface of the ACP particles and prevents them from transformation to crystalline hydroxyapatite. The PPF polymer seems to be more efficient in hindering the ACP to HAp transformation at higher pH conditions. From spectroscopic observations we hypothesize that the C
O bond of the PPF molecules interact with the calcium ion of the ACP particles. In case of low molecular weight PPF this interaction may lead to the incorporation of the polymer within the growing ACP particles.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>16026822</pmid><doi>10.1016/j.biomaterials.2005.05.065</doi><tpages>7</tpages></addata></record> |
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| issn | 0142-9612 1878-5905 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Amorphous calcium phosphate Biocompatible Materials - chemistry Calcium Phosphates Chemical Precipitation Composite Crystallization - methods Durapatite - analysis Durapatite - chemistry Fumarates - analysis Fumarates - chemistry Hydrogen-Ion Concentration In-situ synthesis Materials Testing Molecular Conformation Molecular Weight Poly(propylene fumarate) Polypropylenes - analysis Polypropylenes - chemistry |
| title | In-situ preparation of poly(propylene fumarate)—hydroxyapatite composite |
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