Intercellular Gamma‐Herpesvirus Dissemination Involves Co‐Ordinated Intracellular Membrane Protein Transport

The murine gamma‐herpesvirus‐68 (MHV‐68) ORF27 encodes gp48, a type 2 transmembrane glycoprotein that contributes to intercellular viral spread. Gp48 is expressed on the surface of infected cells but is retained intracellularly after transfection. In this study, we show that the multimembrane spanni...

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Veröffentlicht in:	Traffic (Copenhagen, Denmark) Denmark), 2005-09, Vol.6 (9), p.780-793
Hauptverfasser:	May, Janet S., de Lima, Brigitte D., Colaco, Susanna, Stevenson, Philip G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies Antibodies, Monoclonal - metabolism Cell Line Cell surface Cricetinae Endoplasmic reticulum Endoplasmic Reticulum - ultrastructure Endoplasmic Reticulum - virology Fibroblasts - ultrastructure Fibroblasts - virology Fluorescent Antibody Technique, Indirect gamma‐herpesvirus glycoprotein expression glycoprotein traffic Glycoproteins Glycoproteins - metabolism Glycoproteins - physiology Humans immune evasion Immunoblotting Immunohistochemistry Intracellular Membranes - metabolism Intracellular Membranes - ultrastructure Kidney - cytology Kidney - embryology Membrane proteins Mice Microscopy, Confocal Molecular Sequence Data Mutation NIH 3T3 Cells Precipitin Tests Protein Structure, Tertiary Protein Transport Rhadinovirus - genetics Rhadinovirus - physiology Transfection Viral Proteins - chemistry Viral Proteins - physiology viral spread Virus Replication
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