Tocilizumab inhibits signal transduction mediated by both mIL-6R and sIL-6R, but not by the receptors of other members of IL-6 cytokine family

To characterize the biological activity of tocilizumab, a humanized anti-human interleukin-6 receptor (IL-6R) monoclonal antibody, we examined its binding activity to both soluble IL-6R (sIL-6R) and membrane bound IL-6R (mIL-6R) and its neutralizing activity to other IL-6 family cytokines. ELISA ass...

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Veröffentlicht in:	International immunopharmacology 2005-11, Vol.5 (12), p.1731-1740
Hauptverfasser:	Mihara, Masahiko, Kasutani, Keiko, Okazaki, Makoto, Nakamura, Akito, Kawai, Shigeto, Sugimoto, Masamichi, Matsumoto, Yoshihiro, Ohsugi, Yoshiyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal, Humanized Biological and medical sciences Cell Proliferation - drug effects Cercopithecus aethiops COS Cells Cytokines - immunology Cytokines - metabolism Dose-Response Relationship, Drug Humans IL-6 IL-6 family cytokine IL-6 receptor Interleukin-6 - immunology Interleukin-6 - metabolism Medical sciences Pharmacology. Drug treatments Protein Binding Receptors, Cytokine - immunology Receptors, Cytokine - metabolism Receptors, Interleukin-6 - immunology Receptors, Interleukin-6 - metabolism Signal Transduction - drug effects Signal Transduction - immunology Tocilizumab Transfection
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