Cytotoxic activity and effect on nitric oxide production of tirucallane-type triterpenes
Hexane extract from the bark of Amphipterygium adstringens, as well as its principal constituents, masticadienonic acid (1) and 3α‐hydroxymasticadienolic acid (2), inhibited the growth of five human cancer cell lines. Derivatives of 1, namely 24,25S‐dihydromasticadienonic acid (3) and masticadienoli...
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| Veröffentlicht in: | Journal of pharmacy and pharmacology 2005-09, Vol.57 (9), p.1087-1091 |
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| container_title | Journal of pharmacy and pharmacology |
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| creator | Chávez, Ibeth Oviedo Apan, Teresa Ramírez Martínez-Vázquez, Mariano |
| description | Hexane extract from the bark of Amphipterygium adstringens, as well as its principal constituents, masticadienonic acid (1) and 3α‐hydroxymasticadienolic acid (2), inhibited the growth of five human cancer cell lines. Derivatives of 1, namely 24,25S‐dihydromasticadienonic acid (3) and masticadienolic acid (4), were also evaluated. The results showed that both 3 and 4 had greater activity than 1 on colon cancer cell lines. The effects of 1–4 on the production of nitric oxide (NO) from both resting and lipopolysaccharide‐activated macrophages were determined. It was found that 1, 2 and 4 caused an increase in NO release from resting macrophages; in lipopolysaccharide‐activated macrophages, only 2 and 4 caused an increase in NO production. |
| doi_str_mv | 10.1211/jpp.57.9.0003 |
| format | Article |
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Derivatives of 1, namely 24,25S‐dihydromasticadienonic acid (3) and masticadienolic acid (4), were also evaluated. The results showed that both 3 and 4 had greater activity than 1 on colon cancer cell lines. The effects of 1–4 on the production of nitric oxide (NO) from both resting and lipopolysaccharide‐activated macrophages were determined. It was found that 1, 2 and 4 caused an increase in NO release from resting macrophages; in lipopolysaccharide‐activated macrophages, only 2 and 4 caused an increase in NO production.</description><identifier>ISSN: 0022-3573</identifier><identifier>EISSN: 2042-7158</identifier><identifier>DOI: 10.1211/jpp.57.9.0003</identifier><identifier>PMID: 16105229</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Anacardiaceae ; Animals ; Antineoplastic Agents, Phytogenic - pharmacology ; Antineoplastic Agents, Phytogenic - therapeutic use ; Breast Neoplasms - pathology ; Cell Death - drug effects ; Cell Line, Tumor ; Central Nervous System Neoplasms - pathology ; Colonic Neoplasms - pathology ; Drug Screening Assays, Antitumor - methods ; Female ; Hexanes - chemistry ; Hexanes - pharmacology ; Humans ; Leukemia - pathology ; Lipopolysaccharides - pharmacology ; Macrophages, Peritoneal - drug effects ; Macrophages, Peritoneal - metabolism ; Male ; Medicine, Traditional ; Mexico - ethnology ; Mice ; Nitric Oxide - metabolism ; Plant Extracts - chemistry ; Plant Extracts - isolation & purification ; Prostatic Neoplasms - pathology ; Rhodamines - pharmacology ; Triterpenes - isolation & purification ; Triterpenes - pharmacology ; Triterpenes - therapeutic use ; Ursolic Acid</subject><ispartof>Journal of pharmacy and pharmacology, 2005-09, Vol.57 (9), p.1087-1091</ispartof><rights>2005 Royal Pharmaceutical Society of Great Britain</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3728-84ab6738f8f2dad8b2a42a63a57ed2b62b860981de6496857384b59aee87822c3</citedby><cites>FETCH-LOGICAL-c3728-84ab6738f8f2dad8b2a42a63a57ed2b62b860981de6496857384b59aee87822c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1211%2Fjpp.57.9.0003$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1211%2Fjpp.57.9.0003$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16105229$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chávez, Ibeth Oviedo</creatorcontrib><creatorcontrib>Apan, Teresa Ramírez</creatorcontrib><creatorcontrib>Martínez-Vázquez, Mariano</creatorcontrib><title>Cytotoxic activity and effect on nitric oxide production of tirucallane-type triterpenes</title><title>Journal of pharmacy and pharmacology</title><addtitle>J Pharm Pharmacol</addtitle><description>Hexane extract from the bark of Amphipterygium adstringens, as well as its principal constituents, masticadienonic acid (1) and 3α‐hydroxymasticadienolic acid (2), inhibited the growth of five human cancer cell lines. Derivatives of 1, namely 24,25S‐dihydromasticadienonic acid (3) and masticadienolic acid (4), were also evaluated. The results showed that both 3 and 4 had greater activity than 1 on colon cancer cell lines. The effects of 1–4 on the production of nitric oxide (NO) from both resting and lipopolysaccharide‐activated macrophages were determined. It was found that 1, 2 and 4 caused an increase in NO release from resting macrophages; in lipopolysaccharide‐activated macrophages, only 2 and 4 caused an increase in NO production.</description><subject>Anacardiaceae</subject><subject>Animals</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Antineoplastic Agents, Phytogenic - therapeutic use</subject><subject>Breast Neoplasms - pathology</subject><subject>Cell Death - drug effects</subject><subject>Cell Line, Tumor</subject><subject>Central Nervous System Neoplasms - pathology</subject><subject>Colonic Neoplasms - pathology</subject><subject>Drug Screening Assays, Antitumor - methods</subject><subject>Female</subject><subject>Hexanes - chemistry</subject><subject>Hexanes - pharmacology</subject><subject>Humans</subject><subject>Leukemia - pathology</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Macrophages, Peritoneal - drug effects</subject><subject>Macrophages, Peritoneal - metabolism</subject><subject>Male</subject><subject>Medicine, Traditional</subject><subject>Mexico - ethnology</subject><subject>Mice</subject><subject>Nitric Oxide - metabolism</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - isolation & purification</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Rhodamines - pharmacology</subject><subject>Triterpenes - isolation & purification</subject><subject>Triterpenes - pharmacology</subject><subject>Triterpenes - therapeutic use</subject><subject>Ursolic Acid</subject><issn>0022-3573</issn><issn>2042-7158</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kElPwzAQRi0EomU5ckU5cUuxnXjJEZWloIpFgKh6sZxkIrm0SbAdIP8eQyu4cRrJ8_zpm4fQEcEjQgk5XbTtiIlRNsIYJ1toSHFKY0GY3EZDjCmNEyaSAdpzbhEIwTnfRQPCCWaUZkM0G_e-8c2nKSJdePNufB_puoygqqDwUVNHtfE2bANSQtTapuwCF96bKvLGdoVeLnUNse9biALpwbZQgztAO5VeOjjczH30fHnxNJ7E07ur6_HZNC4SQWUsU51zkchKVrTUpcypTqnmiWYCSppzmkuOM0lK4GnGZbhFpjnLNIAUktIi2Ucn69xQ7a0D59XKuAJ-SjWdU1ymkqWYBTBeg4VtnLNQqdaalba9Ilh9q1RBpWJCZepbZeCPN8FdvoLyj964CwBdAx9mCf3_aermfnIvifxrYZyHz99P2r6qoEEw9XJ7peaT8_n8YfagHpMvZ7uPzQ</recordid><startdate>200509</startdate><enddate>200509</enddate><creator>Chávez, Ibeth Oviedo</creator><creator>Apan, Teresa Ramírez</creator><creator>Martínez-Vázquez, Mariano</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200509</creationdate><title>Cytotoxic activity and effect on nitric oxide production of tirucallane-type triterpenes</title><author>Chávez, Ibeth Oviedo ; Apan, Teresa Ramírez ; Martínez-Vázquez, Mariano</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3728-84ab6738f8f2dad8b2a42a63a57ed2b62b860981de6496857384b59aee87822c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Anacardiaceae</topic><topic>Animals</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Antineoplastic Agents, Phytogenic - therapeutic use</topic><topic>Breast Neoplasms - pathology</topic><topic>Cell Death - drug effects</topic><topic>Cell Line, Tumor</topic><topic>Central Nervous System Neoplasms - pathology</topic><topic>Colonic Neoplasms - pathology</topic><topic>Drug Screening Assays, Antitumor - methods</topic><topic>Female</topic><topic>Hexanes - chemistry</topic><topic>Hexanes - pharmacology</topic><topic>Humans</topic><topic>Leukemia - pathology</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Macrophages, Peritoneal - drug effects</topic><topic>Macrophages, Peritoneal - metabolism</topic><topic>Male</topic><topic>Medicine, Traditional</topic><topic>Mexico - ethnology</topic><topic>Mice</topic><topic>Nitric Oxide - metabolism</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - isolation & purification</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Rhodamines - pharmacology</topic><topic>Triterpenes - isolation & purification</topic><topic>Triterpenes - pharmacology</topic><topic>Triterpenes - therapeutic use</topic><topic>Ursolic Acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chávez, Ibeth Oviedo</creatorcontrib><creatorcontrib>Apan, Teresa Ramírez</creatorcontrib><creatorcontrib>Martínez-Vázquez, Mariano</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmacy and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chávez, Ibeth Oviedo</au><au>Apan, Teresa Ramírez</au><au>Martínez-Vázquez, Mariano</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytotoxic activity and effect on nitric oxide production of tirucallane-type triterpenes</atitle><jtitle>Journal of pharmacy and pharmacology</jtitle><addtitle>J Pharm Pharmacol</addtitle><date>2005-09</date><risdate>2005</risdate><volume>57</volume><issue>9</issue><spage>1087</spage><epage>1091</epage><pages>1087-1091</pages><issn>0022-3573</issn><eissn>2042-7158</eissn><abstract>Hexane extract from the bark of Amphipterygium adstringens, as well as its principal constituents, masticadienonic acid (1) and 3α‐hydroxymasticadienolic acid (2), inhibited the growth of five human cancer cell lines. Derivatives of 1, namely 24,25S‐dihydromasticadienonic acid (3) and masticadienolic acid (4), were also evaluated. The results showed that both 3 and 4 had greater activity than 1 on colon cancer cell lines. The effects of 1–4 on the production of nitric oxide (NO) from both resting and lipopolysaccharide‐activated macrophages were determined. It was found that 1, 2 and 4 caused an increase in NO release from resting macrophages; in lipopolysaccharide‐activated macrophages, only 2 and 4 caused an increase in NO production.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>16105229</pmid><doi>10.1211/jpp.57.9.0003</doi><tpages>5</tpages></addata></record> |
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| subjects | Anacardiaceae Animals Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Agents, Phytogenic - therapeutic use Breast Neoplasms - pathology Cell Death - drug effects Cell Line, Tumor Central Nervous System Neoplasms - pathology Colonic Neoplasms - pathology Drug Screening Assays, Antitumor - methods Female Hexanes - chemistry Hexanes - pharmacology Humans Leukemia - pathology Lipopolysaccharides - pharmacology Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - metabolism Male Medicine, Traditional Mexico - ethnology Mice Nitric Oxide - metabolism Plant Extracts - chemistry Plant Extracts - isolation & purification Prostatic Neoplasms - pathology Rhodamines - pharmacology Triterpenes - isolation & purification Triterpenes - pharmacology Triterpenes - therapeutic use Ursolic Acid |
| title | Cytotoxic activity and effect on nitric oxide production of tirucallane-type triterpenes |
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