11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice

The enzyme 11beta-hydroxysteroid dehydrogenase (HSD) type 1 converts inactive cortisone into active cortisol in cells, thereby raising the effective glucocorticoid (GC) tone above serum levels. We report that pharmacologic inhibition of 11beta-HSD1 has a therapeutic effect in mouse models of metabol...

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Veröffentlicht in:	The Journal of experimental medicine 2005-08, Vol.202 (4), p.517-527
Hauptverfasser:	Hermanowski-Vosatka, Anne, Balkovec, James M, Cheng, Kang, Chen, Howard Y, Hernandez, Melba, Koo, Gloria C, Le Grand, Cheryl B, Li, Zhihua, Metzger, Joseph M, Mundt, Steven S, Noonan, Heather, Nunes, Christian N, Olson, Steven H, Pikounis, Bill, Ren, Ning, Robertson, Nancy, Schaeffer, James M, Shah, Kashmira, Springer, Martin S, Strack, Alison M, Strowski, Matthias, Wu, Kenneth, Wu, Tsueiju, Xiao, Jianying, Zhang, Bei B, Wright, Samuel D, Thieringer, Rolf
Format:	Artikel
Sprache:	eng
Schlagworte:	11-beta-Hydroxysteroid Dehydrogenase Type 1 - antagonists & inhibitors 11-beta-Hydroxysteroid Dehydrogenase Type 1 - metabolism Adamantane - administration & dosage Adamantane - analogs & derivatives Animals Aorta - metabolism Arteriosclerosis - complications Arteriosclerosis - drug therapy Arteriosclerosis - enzymology Azepines - administration & dosage Blood Glucose - drug effects Cortisone - metabolism Diet, Atherogenic Disease Models, Animal Enzyme Activation - drug effects Enzyme Inhibitors - administration & dosage Fatty Acids - blood Hydrocortisone Insulin - blood Insulin Resistance Male Mice Mice, Inbred ICR Mice, Knockout Syndrome Triazoles - administration & dosage Triglycerides - blood
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