Expression of p53 and its homolog, p73, in HPV DNA positive oesophageal squamous cell carcinomas
Abstract Several studies have detected human papilloma virus (HPV) DNA in squamous cell carcinoma of the oesophagus (OSCC). In this study, we analysed OSCC specimens from 114 patients for the presence of HPV DNA, and p53 and p73 expression. HPV DNA was detected in 44.7% of cases, with the low risk H...
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| Veröffentlicht in: | Virology (New York, N.Y.) N.Y.), 2007-12, Vol.369 (1), p.182-190 |
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| creator | Matsha, T Donninger, H Erasmus, R.T Hendricks, D Stepien, A Parker, M.I |
| description | Abstract Several studies have detected human papilloma virus (HPV) DNA in squamous cell carcinoma of the oesophagus (OSCC). In this study, we analysed OSCC specimens from 114 patients for the presence of HPV DNA, and p53 and p73 expression. HPV DNA was detected in 44.7% of cases, with the low risk HPV11 occurring most frequently. p53 and p73 expression was detected in 70% and 61.4% of cases, respectively. There was no correlation between expression of p53, p73 or HPV infection and tumour grade, or between p53 expression and the presence of HPV DNA. There was, however, significant correlation between p73 expression and the presence of HPV DNA ( p < 0.01) and p53 and p73 co-expression ( p < 0.001), as well as co-expression of p53 and p73 with HPV status ( p < 0.05). These data support previous studies suggesting a role for HPV infection in OSCC and also indicate that HPV infection and p53 and p73 overexpression are not mutually exclusive. In addition, the data implicate a role for p73 in OSCC and suggest a complex interaction between p53, p73 and HPV in the aetiology of the disease. |
| doi_str_mv | 10.1016/j.virol.2007.07.025 |
| format | Article |
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In this study, we analysed OSCC specimens from 114 patients for the presence of HPV DNA, and p53 and p73 expression. HPV DNA was detected in 44.7% of cases, with the low risk HPV11 occurring most frequently. p53 and p73 expression was detected in 70% and 61.4% of cases, respectively. There was no correlation between expression of p53, p73 or HPV infection and tumour grade, or between p53 expression and the presence of HPV DNA. There was, however, significant correlation between p73 expression and the presence of HPV DNA ( p < 0.01) and p53 and p73 co-expression ( p < 0.001), as well as co-expression of p53 and p73 with HPV status ( p < 0.05). These data support previous studies suggesting a role for HPV infection in OSCC and also indicate that HPV infection and p53 and p73 overexpression are not mutually exclusive. 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| subjects | Carcinoma, Squamous Cell - chemistry Carcinoma, Squamous Cell - virology DNA, Viral - analysis DNA, Viral - genetics DNA-Binding Proteins - biosynthesis Esophageal Neoplasms - chemistry Esophageal Neoplasms - virology Human papilloma virus Human papilloma virus 11 Human papillomavirus Humans Infectious Disease Nuclear Proteins - biosynthesis Oesophageal cancer p53 p73 Papillomaviridae - classification Papillomaviridae - genetics Papillomaviridae - isolation & purification Tumor Protein p73 Tumor Suppressor Protein p53 - biosynthesis Tumor Suppressor Proteins - biosynthesis |
| title | Expression of p53 and its homolog, p73, in HPV DNA positive oesophageal squamous cell carcinomas |
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