Effects of Histone Acetylation on Sodium Iodide Symporter Promoter and Expression of Thyroid-Specific Transcription Factors
Inhibitors of histone deacetylases (HDACs) activate the sodium iodide symporter (NIS) expression in thyroid tumor cells. In this study, mechanisms accounting for these effects were investigated. Various human thyroid tumor cell lines (ARO, BCPAP, FRO, TPC-1) were treated with the HDAC inhibitors Na...
Gespeichert in:
| Veröffentlicht in: | Endocrinology (Philadelphia) 2005-09, Vol.146 (9), p.3967-3974 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3974 |
|---|---|
| container_issue | 9 |
| container_start_page | 3967 |
| container_title | Endocrinology (Philadelphia) |
| container_volume | 146 |
| creator | Puppin, Cinzia D’Aurizio, Federica D’Elia, Angela V Cesaratto, Laura Tell, Gianluca Russo, Diego Filetti, Sebastiano Ferretti, Elisabetta Tosi, Emanuele Mattei, Tiziana Pianta, Annalisa Pellizzari, Lucia Damante, Giuseppe |
| description | Inhibitors of histone deacetylases (HDACs) activate the sodium iodide symporter (NIS) expression in thyroid tumor cells. In this study, mechanisms accounting for these effects were investigated. Various human thyroid tumor cell lines (ARO, BCPAP, FRO, TPC-1) were treated with the HDAC inhibitors Na butyrate (NaB) and tricostatin A (TSA), and the effects on the expression of NIS and several thyroid-specific transcription factors together with the activity of NIS promoter were evaluated. TSA and NaB increased NIS mRNA levels in all cell lines. Among thyroid-specific transcription factors, only expression of PAX8 in ARO cells was increased. Down-regulation of thyroid-specific transcription factor-1 expression was observed in BCPAP and TPC-1 cell lines. Thyroid-specific transcription factor-2 mRNA was reduced in FRO, BCPAP, and TPC-1 cells. Histone acetylation had no significant effects on HEX expression. Altogether, these data indicate that the increase of NIS expression is not mediated by modification of expression of thyroid-specific transcription factors. Accordingly, in transfection experiments performed in the HeLa cell line (which does not express thyroid-specific transcription factors), treatment with TSA and NaB increased NIS promoter activity. Stimulation of NIS promoter activity was also obtained by overexpressing histone acetylating proteins pCAF and p300 in HeLa cells. Conversely, overexpression of the HDAC 1 enzyme inhibited basal activity of the NIS promoter. Effects of TSA and NaB on NIS expression were also evaluated in nonthyroid cell lines MCF-7, Hep-G2, and SAOS-2. In all cell lines TSA and NaB greatly increased NIS mRNA levels. We concluded that control of NIS expression by inhibition of HDAC appears not to be mediated by cell-specific mechanisms, suggesting it as a potential strategy to induce radioiodine sensitivity in different human tumors. |
| doi_str_mv | 10.1210/en.2005-0128 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68483116</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1210/en.2005-0128</oup_id><sourcerecordid>68483116</sourcerecordid><originalsourceid>FETCH-LOGICAL-c457t-16ba88e2efddcc8e26afbf1309992a2b08dfbdf160f893de88c0076ef5770f5a3</originalsourceid><addsrcrecordid>eNp1kd2L1DAUxYMo7rj65rMERH2xaz7apn1clll3YUFhxueQJjeYpU1q0sIO_vOmM4UBUQjcG_jlnJt7EHpLyRVllHwBf8UIqQpCWfMMbWhbVoWggjxHG0IoLwRj4gK9SukxX8uy5C_RBa1a2oqq3KDfW2tBTwkHi-9cmoIHfK1hOvRqcsHjfHbBuHnA97kYwLvDMIY4QcTfYxjC0ihv8PZpjJDS8YnF-5-HGJwpdiNoZ53G-6h80tGNR9FbpacQ02v0wqo-wZu1XqIft9v9zV3x8O3r_c31Q6HLSkwFrTvVNMDAGqN1bmplO0s5aduWKdaRxtjOWFoT27TcQNNoQkQNthKC2ErxS_TxpDvG8GuGNMnBJQ19rzyEOcm6KRtOaZ3B93-Bj2GOPs8mefarBG2ZyNTnE6VjSCmClWN0g4oHSYlcIpHg5RKJXCLJ-LtVdO4GMGd4zSADH1ZAJa16m1elXTpzgnBR0kXo04kL8_g_y2K15CcSvAl56x6O4Zx_889B_wAeObKf</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3130571927</pqid></control><display><type>article</type><title>Effects of Histone Acetylation on Sodium Iodide Symporter Promoter and Expression of Thyroid-Specific Transcription Factors</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Puppin, Cinzia ; D’Aurizio, Federica ; D’Elia, Angela V ; Cesaratto, Laura ; Tell, Gianluca ; Russo, Diego ; Filetti, Sebastiano ; Ferretti, Elisabetta ; Tosi, Emanuele ; Mattei, Tiziana ; Pianta, Annalisa ; Pellizzari, Lucia ; Damante, Giuseppe</creator><creatorcontrib>Puppin, Cinzia ; D’Aurizio, Federica ; D’Elia, Angela V ; Cesaratto, Laura ; Tell, Gianluca ; Russo, Diego ; Filetti, Sebastiano ; Ferretti, Elisabetta ; Tosi, Emanuele ; Mattei, Tiziana ; Pianta, Annalisa ; Pellizzari, Lucia ; Damante, Giuseppe</creatorcontrib><description>Inhibitors of histone deacetylases (HDACs) activate the sodium iodide symporter (NIS) expression in thyroid tumor cells. In this study, mechanisms accounting for these effects were investigated. Various human thyroid tumor cell lines (ARO, BCPAP, FRO, TPC-1) were treated with the HDAC inhibitors Na butyrate (NaB) and tricostatin A (TSA), and the effects on the expression of NIS and several thyroid-specific transcription factors together with the activity of NIS promoter were evaluated. TSA and NaB increased NIS mRNA levels in all cell lines. Among thyroid-specific transcription factors, only expression of PAX8 in ARO cells was increased. Down-regulation of thyroid-specific transcription factor-1 expression was observed in BCPAP and TPC-1 cell lines. Thyroid-specific transcription factor-2 mRNA was reduced in FRO, BCPAP, and TPC-1 cells. Histone acetylation had no significant effects on HEX expression. Altogether, these data indicate that the increase of NIS expression is not mediated by modification of expression of thyroid-specific transcription factors. Accordingly, in transfection experiments performed in the HeLa cell line (which does not express thyroid-specific transcription factors), treatment with TSA and NaB increased NIS promoter activity. Stimulation of NIS promoter activity was also obtained by overexpressing histone acetylating proteins pCAF and p300 in HeLa cells. Conversely, overexpression of the HDAC 1 enzyme inhibited basal activity of the NIS promoter. Effects of TSA and NaB on NIS expression were also evaluated in nonthyroid cell lines MCF-7, Hep-G2, and SAOS-2. In all cell lines TSA and NaB greatly increased NIS mRNA levels. We concluded that control of NIS expression by inhibition of HDAC appears not to be mediated by cell-specific mechanisms, suggesting it as a potential strategy to induce radioiodine sensitivity in different human tumors.</description><identifier>ISSN: 0013-7227</identifier><identifier>EISSN: 1945-7170</identifier><identifier>DOI: 10.1210/en.2005-0128</identifier><identifier>PMID: 15919754</identifier><identifier>CODEN: ENDOAO</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Acetylation ; Biological and medical sciences ; Breast Neoplasms ; Carcinoma, Hepatocellular ; Cell Line, Tumor ; Enzyme Inhibitors - pharmacology ; Fundamental and applied biological sciences. Psychology ; Gene expression ; Gene Expression - physiology ; Gene Expression Regulation, Neoplastic ; Gene regulation ; Histone deacetylase ; Histone Deacetylase Inhibitors ; Histone Deacetylases - metabolism ; Histones ; Histones - metabolism ; Humans ; Inhibitors ; Iodides ; Iodine 131 ; Iodine radioisotopes ; Liver Neoplasms ; Osteosarcoma ; Pax8 protein ; Promoter Regions, Genetic - physiology ; Sodium ; Sodium iodide ; Sodium iodide symporter ; Symporters - genetics ; Thyroid ; Thyroid gland ; Thyroid Neoplasms - genetics ; Thyroid Neoplasms - metabolism ; Transcription factors ; Transcription Factors - metabolism ; Transfection ; Tumor cell lines ; Tumor cells ; Tumors ; Vertebrates: endocrinology</subject><ispartof>Endocrinology (Philadelphia), 2005-09, Vol.146 (9), p.3967-3974</ispartof><rights>Copyright © 2005 by The Endocrine Society 2005</rights><rights>2005 INIST-CNRS</rights><rights>Copyright © 2005 by The Endocrine Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-16ba88e2efddcc8e26afbf1309992a2b08dfbdf160f893de88c0076ef5770f5a3</citedby><cites>FETCH-LOGICAL-c457t-16ba88e2efddcc8e26afbf1309992a2b08dfbdf160f893de88c0076ef5770f5a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17037418$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15919754$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Puppin, Cinzia</creatorcontrib><creatorcontrib>D’Aurizio, Federica</creatorcontrib><creatorcontrib>D’Elia, Angela V</creatorcontrib><creatorcontrib>Cesaratto, Laura</creatorcontrib><creatorcontrib>Tell, Gianluca</creatorcontrib><creatorcontrib>Russo, Diego</creatorcontrib><creatorcontrib>Filetti, Sebastiano</creatorcontrib><creatorcontrib>Ferretti, Elisabetta</creatorcontrib><creatorcontrib>Tosi, Emanuele</creatorcontrib><creatorcontrib>Mattei, Tiziana</creatorcontrib><creatorcontrib>Pianta, Annalisa</creatorcontrib><creatorcontrib>Pellizzari, Lucia</creatorcontrib><creatorcontrib>Damante, Giuseppe</creatorcontrib><title>Effects of Histone Acetylation on Sodium Iodide Symporter Promoter and Expression of Thyroid-Specific Transcription Factors</title><title>Endocrinology (Philadelphia)</title><addtitle>Endocrinology</addtitle><description>Inhibitors of histone deacetylases (HDACs) activate the sodium iodide symporter (NIS) expression in thyroid tumor cells. In this study, mechanisms accounting for these effects were investigated. Various human thyroid tumor cell lines (ARO, BCPAP, FRO, TPC-1) were treated with the HDAC inhibitors Na butyrate (NaB) and tricostatin A (TSA), and the effects on the expression of NIS and several thyroid-specific transcription factors together with the activity of NIS promoter were evaluated. TSA and NaB increased NIS mRNA levels in all cell lines. Among thyroid-specific transcription factors, only expression of PAX8 in ARO cells was increased. Down-regulation of thyroid-specific transcription factor-1 expression was observed in BCPAP and TPC-1 cell lines. Thyroid-specific transcription factor-2 mRNA was reduced in FRO, BCPAP, and TPC-1 cells. Histone acetylation had no significant effects on HEX expression. Altogether, these data indicate that the increase of NIS expression is not mediated by modification of expression of thyroid-specific transcription factors. Accordingly, in transfection experiments performed in the HeLa cell line (which does not express thyroid-specific transcription factors), treatment with TSA and NaB increased NIS promoter activity. Stimulation of NIS promoter activity was also obtained by overexpressing histone acetylating proteins pCAF and p300 in HeLa cells. Conversely, overexpression of the HDAC 1 enzyme inhibited basal activity of the NIS promoter. Effects of TSA and NaB on NIS expression were also evaluated in nonthyroid cell lines MCF-7, Hep-G2, and SAOS-2. In all cell lines TSA and NaB greatly increased NIS mRNA levels. We concluded that control of NIS expression by inhibition of HDAC appears not to be mediated by cell-specific mechanisms, suggesting it as a potential strategy to induce radioiodine sensitivity in different human tumors.</description><subject>Acetylation</subject><subject>Biological and medical sciences</subject><subject>Breast Neoplasms</subject><subject>Carcinoma, Hepatocellular</subject><subject>Cell Line, Tumor</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression</subject><subject>Gene Expression - physiology</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Gene regulation</subject><subject>Histone deacetylase</subject><subject>Histone Deacetylase Inhibitors</subject><subject>Histone Deacetylases - metabolism</subject><subject>Histones</subject><subject>Histones - metabolism</subject><subject>Humans</subject><subject>Inhibitors</subject><subject>Iodides</subject><subject>Iodine 131</subject><subject>Iodine radioisotopes</subject><subject>Liver Neoplasms</subject><subject>Osteosarcoma</subject><subject>Pax8 protein</subject><subject>Promoter Regions, Genetic - physiology</subject><subject>Sodium</subject><subject>Sodium iodide</subject><subject>Sodium iodide symporter</subject><subject>Symporters - genetics</subject><subject>Thyroid</subject><subject>Thyroid gland</subject><subject>Thyroid Neoplasms - genetics</subject><subject>Thyroid Neoplasms - metabolism</subject><subject>Transcription factors</subject><subject>Transcription Factors - metabolism</subject><subject>Transfection</subject><subject>Tumor cell lines</subject><subject>Tumor cells</subject><subject>Tumors</subject><subject>Vertebrates: endocrinology</subject><issn>0013-7227</issn><issn>1945-7170</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kd2L1DAUxYMo7rj65rMERH2xaz7apn1clll3YUFhxueQJjeYpU1q0sIO_vOmM4UBUQjcG_jlnJt7EHpLyRVllHwBf8UIqQpCWfMMbWhbVoWggjxHG0IoLwRj4gK9SukxX8uy5C_RBa1a2oqq3KDfW2tBTwkHi-9cmoIHfK1hOvRqcsHjfHbBuHnA97kYwLvDMIY4QcTfYxjC0ihv8PZpjJDS8YnF-5-HGJwpdiNoZ53G-6h80tGNR9FbpacQ02v0wqo-wZu1XqIft9v9zV3x8O3r_c31Q6HLSkwFrTvVNMDAGqN1bmplO0s5aduWKdaRxtjOWFoT27TcQNNoQkQNthKC2ErxS_TxpDvG8GuGNMnBJQ19rzyEOcm6KRtOaZ3B93-Bj2GOPs8mefarBG2ZyNTnE6VjSCmClWN0g4oHSYlcIpHg5RKJXCLJ-LtVdO4GMGd4zSADH1ZAJa16m1elXTpzgnBR0kXo04kL8_g_y2K15CcSvAl56x6O4Zx_889B_wAeObKf</recordid><startdate>20050901</startdate><enddate>20050901</enddate><creator>Puppin, Cinzia</creator><creator>D’Aurizio, Federica</creator><creator>D’Elia, Angela V</creator><creator>Cesaratto, Laura</creator><creator>Tell, Gianluca</creator><creator>Russo, Diego</creator><creator>Filetti, Sebastiano</creator><creator>Ferretti, Elisabetta</creator><creator>Tosi, Emanuele</creator><creator>Mattei, Tiziana</creator><creator>Pianta, Annalisa</creator><creator>Pellizzari, Lucia</creator><creator>Damante, Giuseppe</creator><general>Endocrine Society</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20050901</creationdate><title>Effects of Histone Acetylation on Sodium Iodide Symporter Promoter and Expression of Thyroid-Specific Transcription Factors</title><author>Puppin, Cinzia ; D’Aurizio, Federica ; D’Elia, Angela V ; Cesaratto, Laura ; Tell, Gianluca ; Russo, Diego ; Filetti, Sebastiano ; Ferretti, Elisabetta ; Tosi, Emanuele ; Mattei, Tiziana ; Pianta, Annalisa ; Pellizzari, Lucia ; Damante, Giuseppe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-16ba88e2efddcc8e26afbf1309992a2b08dfbdf160f893de88c0076ef5770f5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acetylation</topic><topic>Biological and medical sciences</topic><topic>Breast Neoplasms</topic><topic>Carcinoma, Hepatocellular</topic><topic>Cell Line, Tumor</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene expression</topic><topic>Gene Expression - physiology</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Gene regulation</topic><topic>Histone deacetylase</topic><topic>Histone Deacetylase Inhibitors</topic><topic>Histone Deacetylases - metabolism</topic><topic>Histones</topic><topic>Histones - metabolism</topic><topic>Humans</topic><topic>Inhibitors</topic><topic>Iodides</topic><topic>Iodine 131</topic><topic>Iodine radioisotopes</topic><topic>Liver Neoplasms</topic><topic>Osteosarcoma</topic><topic>Pax8 protein</topic><topic>Promoter Regions, Genetic - physiology</topic><topic>Sodium</topic><topic>Sodium iodide</topic><topic>Sodium iodide symporter</topic><topic>Symporters - genetics</topic><topic>Thyroid</topic><topic>Thyroid gland</topic><topic>Thyroid Neoplasms - genetics</topic><topic>Thyroid Neoplasms - metabolism</topic><topic>Transcription factors</topic><topic>Transcription Factors - metabolism</topic><topic>Transfection</topic><topic>Tumor cell lines</topic><topic>Tumor cells</topic><topic>Tumors</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Puppin, Cinzia</creatorcontrib><creatorcontrib>D’Aurizio, Federica</creatorcontrib><creatorcontrib>D’Elia, Angela V</creatorcontrib><creatorcontrib>Cesaratto, Laura</creatorcontrib><creatorcontrib>Tell, Gianluca</creatorcontrib><creatorcontrib>Russo, Diego</creatorcontrib><creatorcontrib>Filetti, Sebastiano</creatorcontrib><creatorcontrib>Ferretti, Elisabetta</creatorcontrib><creatorcontrib>Tosi, Emanuele</creatorcontrib><creatorcontrib>Mattei, Tiziana</creatorcontrib><creatorcontrib>Pianta, Annalisa</creatorcontrib><creatorcontrib>Pellizzari, Lucia</creatorcontrib><creatorcontrib>Damante, Giuseppe</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrinology (Philadelphia)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Puppin, Cinzia</au><au>D’Aurizio, Federica</au><au>D’Elia, Angela V</au><au>Cesaratto, Laura</au><au>Tell, Gianluca</au><au>Russo, Diego</au><au>Filetti, Sebastiano</au><au>Ferretti, Elisabetta</au><au>Tosi, Emanuele</au><au>Mattei, Tiziana</au><au>Pianta, Annalisa</au><au>Pellizzari, Lucia</au><au>Damante, Giuseppe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Histone Acetylation on Sodium Iodide Symporter Promoter and Expression of Thyroid-Specific Transcription Factors</atitle><jtitle>Endocrinology (Philadelphia)</jtitle><addtitle>Endocrinology</addtitle><date>2005-09-01</date><risdate>2005</risdate><volume>146</volume><issue>9</issue><spage>3967</spage><epage>3974</epage><pages>3967-3974</pages><issn>0013-7227</issn><eissn>1945-7170</eissn><coden>ENDOAO</coden><abstract>Inhibitors of histone deacetylases (HDACs) activate the sodium iodide symporter (NIS) expression in thyroid tumor cells. In this study, mechanisms accounting for these effects were investigated. Various human thyroid tumor cell lines (ARO, BCPAP, FRO, TPC-1) were treated with the HDAC inhibitors Na butyrate (NaB) and tricostatin A (TSA), and the effects on the expression of NIS and several thyroid-specific transcription factors together with the activity of NIS promoter were evaluated. TSA and NaB increased NIS mRNA levels in all cell lines. Among thyroid-specific transcription factors, only expression of PAX8 in ARO cells was increased. Down-regulation of thyroid-specific transcription factor-1 expression was observed in BCPAP and TPC-1 cell lines. Thyroid-specific transcription factor-2 mRNA was reduced in FRO, BCPAP, and TPC-1 cells. Histone acetylation had no significant effects on HEX expression. Altogether, these data indicate that the increase of NIS expression is not mediated by modification of expression of thyroid-specific transcription factors. Accordingly, in transfection experiments performed in the HeLa cell line (which does not express thyroid-specific transcription factors), treatment with TSA and NaB increased NIS promoter activity. Stimulation of NIS promoter activity was also obtained by overexpressing histone acetylating proteins pCAF and p300 in HeLa cells. Conversely, overexpression of the HDAC 1 enzyme inhibited basal activity of the NIS promoter. Effects of TSA and NaB on NIS expression were also evaluated in nonthyroid cell lines MCF-7, Hep-G2, and SAOS-2. In all cell lines TSA and NaB greatly increased NIS mRNA levels. We concluded that control of NIS expression by inhibition of HDAC appears not to be mediated by cell-specific mechanisms, suggesting it as a potential strategy to induce radioiodine sensitivity in different human tumors.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>15919754</pmid><doi>10.1210/en.2005-0128</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0013-7227 |
| ispartof | Endocrinology (Philadelphia), 2005-09, Vol.146 (9), p.3967-3974 |
| issn | 0013-7227 1945-7170 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68483116 |
| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Acetylation Biological and medical sciences Breast Neoplasms Carcinoma, Hepatocellular Cell Line, Tumor Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Gene expression Gene Expression - physiology Gene Expression Regulation, Neoplastic Gene regulation Histone deacetylase Histone Deacetylase Inhibitors Histone Deacetylases - metabolism Histones Histones - metabolism Humans Inhibitors Iodides Iodine 131 Iodine radioisotopes Liver Neoplasms Osteosarcoma Pax8 protein Promoter Regions, Genetic - physiology Sodium Sodium iodide Sodium iodide symporter Symporters - genetics Thyroid Thyroid gland Thyroid Neoplasms - genetics Thyroid Neoplasms - metabolism Transcription factors Transcription Factors - metabolism Transfection Tumor cell lines Tumor cells Tumors Vertebrates: endocrinology |
| title | Effects of Histone Acetylation on Sodium Iodide Symporter Promoter and Expression of Thyroid-Specific Transcription Factors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T18%3A06%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20Histone%20Acetylation%20on%20Sodium%20Iodide%20Symporter%20Promoter%20and%20Expression%20of%20Thyroid-Specific%20Transcription%20Factors&rft.jtitle=Endocrinology%20(Philadelphia)&rft.au=Puppin,%20Cinzia&rft.date=2005-09-01&rft.volume=146&rft.issue=9&rft.spage=3967&rft.epage=3974&rft.pages=3967-3974&rft.issn=0013-7227&rft.eissn=1945-7170&rft.coden=ENDOAO&rft_id=info:doi/10.1210/en.2005-0128&rft_dat=%3Cproquest_cross%3E68483116%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3130571927&rft_id=info:pmid/15919754&rft_oup_id=10.1210/en.2005-0128&rfr_iscdi=true |