Platelet GPIb‐IX‐V‐dependent signaling

Although the signaling pathways related to GPIb‐IX‐V have not been fully elucidated, an accumulating body of evidence suggests that phospholipase C (PLC)γ2 activation, subsequent Ca++ release and oscillations constitute an essential signal transduction pathway related to GPIb‐IX‐V. Src family kinase...

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Veröffentlicht in:	Journal of thrombosis and haemostasis 2005-08, Vol.3 (8), p.1745-1751
Hauptverfasser:	OZAKI, Y., ASAZUMA, N., SUZUKI‐INOUE, K., BERNDT, M.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - chemistry Blood Platelets - metabolism Ca++ mobilization Calcium - metabolism Cyclic GMP - metabolism Cytoskeleton - metabolism Glycosphingolipids - chemistry Glycosphingolipids - metabolism GPIb‐IX‐V Humans Membrane Microdomains - chemistry Models, Biological Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Platelet Glycoprotein GPIb-IX Complex - metabolism Platelets PLCγ2 Receptors, IgG - chemistry Receptors, IgG - metabolism Signal Transduction Tyrosine - chemistry Tyrosine - metabolism tyrosine kinases
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