Endothelin axis is a target of the lung metastasis suppressor gene RhoGDI2

Half of patients treated for locally advanced bladder cancer relapse with often fatal metastatic disease to the lung. We have recently shown that reduced expression of the GDP dissociation inhibitor, RhoGDI2, is associated with decreased survival of patients with advanced bladder cancer. However, th...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2005-08, Vol.65 (16), p.7320-7327
Hauptverfasser:	TITUS, Brian, FRIERSON, Henry F, CONAWAY, Mark, CHING, Keith, GUISE, Theresa, CHIRGWIN, John, HAMPTON, Garret, THEODORESCU, Dan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Line, Tumor Down-Regulation Endothelin-1 - antagonists & inhibitors Endothelin-1 - biosynthesis Endothelin-1 - metabolism Gene Expression Regulation, Neoplastic Genes, Tumor Suppressor Guanine Nucleotide Dissociation Inhibitors - genetics Humans Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - secondary Medical sciences Mice Mice, Nude Neoplasm Staging Oligonucleotide Array Sequence Analysis Pneumology rho Guanine Nucleotide Dissociation Inhibitor beta rho-Specific Guanine Nucleotide Dissociation Inhibitors Transfection Tumor Suppressor Proteins - genetics Tumors of the respiratory system and mediastinum Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - pathology
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