Glycosylated neuropeptides: A new vista for neuropsychopharmacology?

The application of endogenous neuropeptides (e.g., enkephalins) as analgesics has been retarded by their poor stability in vivo and by their inability to effectively penetrate the blood–brain barrier (BBB). Effective BBB transport of glycosylated enkephalins has been demonstrated in several labs now...

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Veröffentlicht in:	Medicinal research reviews 2005-09, Vol.25 (5), p.557-585
Hauptverfasser:	Polt, Robin, Dhanasekaran, Muthu, Keyari, Charles M.
Format:	Artikel
Sprache:	eng
Schlagworte:	analgesia Animals Behavior, Animal - drug effects blood-brain barrier enkephalin glycopeptide Glycopeptides - chemistry Glycopeptides - pharmacology Humans morphine Narcotics - pharmacology Neuropeptides - chemistry Neuropeptides - pharmacology Neuropsychology - trends opioid Pharmacology - trends transcytosis
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