Small hairpin RNAs efficiently inhibit hepatitis C IRES-mediated gene expression in human tissue culture cells and a mouse model

Treatment and prevention of hepatitis C virus (HCV) infections remain a major challenge for controlling this worldwide health problem; existing therapies are only partially effective and no vaccine is currently available. RNA interference offers the potential of a novel therapeutic approach for trea...

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Veröffentlicht in:	Molecular therapy 2005-09, Vol.12 (3), p.562-568
Hauptverfasser:	Wang, Qian, Contag, Christopher H, Ilves, Heini, Johnston, Brian H, Kaspar, Roger L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Binding Sites Cell Line Cells, Cultured Disease Models, Animal Dose-Response Relationship, Drug Gene expression Gene Expression Regulation Genes, Reporter Genetic Therapy - methods Genetic Vectors Genome, Viral Hepatitis C Hepatitis C - genetics Hepatitis C - therapy Humans Liver Luciferases - metabolism Mice Molecular Sequence Data Plasmids - metabolism Ribonucleic acid Ribosomes - metabolism RNA RNA - chemistry RNA - metabolism RNA Interference Time Factors Transfection Viruses
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