Role of Rho-kinase in regulation of insulin action and glucose homeostasis

Accumulating evidence indicates an important role for serine phosphorylation of IRS-1 in the regulation of insulin action. Recent studies suggest that Rho-kinase (ROK) is a mediator of insulin signaling, via interaction with IRS-1. Here we show that insulin stimulation of glucose transport is impair...

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Veröffentlicht in:	Cell metabolism 2005-08, Vol.2 (2), p.119-129
Hauptverfasser:	Furukawa, Noboru, Ongusaha, Pat, Jahng, Wan Jin, Araki, Kazushi, Choi, Cheol Soo, Kim, Hyo-Jeong, Lee, Yong Hee, Kaibuchi, Kozo, Kahn, Barbara B., Masuzaki, Hiroaki, Kim, Jason K., Lee, Sam W., Kim, Young-Bum
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - cytology Adipocytes - metabolism Animals Cell Line Cricetinae Glucose - metabolism Homeostasis Humans Insulin - metabolism Insulin Receptor Substrate Proteins Intracellular Signaling Peptides and Proteins Mice Muscle Fibers, Skeletal - cytology Muscle Fibers, Skeletal - metabolism Muscle, Skeletal - metabolism Phosphoproteins - metabolism Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism rho-Associated Kinases RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Signal Transduction - physiology
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