Allergies and the Risk of Pancreatic Cancer: A Meta-analysis with Review of Epidemiology and Biological Mechanisms
Previous reports suggest that allergic disorders may protect against various types of cancer, but the association between history of allergy and pancreatic cancer risk has not been well studied. We did a systematic review and meta-analysis of published studies to evaluate the association of any type...
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| Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2005-08, Vol.14 (8), p.1908-1916 |
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| container_title | Cancer epidemiology, biomarkers & prevention |
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| creator | GANDINI, Sara LOWENFELS, Albert B JAFFEE, Elizabeth M ARMSTRONG, Todd D MAISONNEUVE, Patrick |
| description | Previous reports suggest that allergic disorders may protect against various types of cancer, but the association between
history of allergy and pancreatic cancer risk has not been well studied. We did a systematic review and meta-analysis of published
studies to evaluate the association of any type, and specific types, of allergy and the risk of pancreatic cancer. We did
a comprehensive literature search using MEDLINE, PUBMED, and the ISI Web of Science databases to identify potential relevant
case-control and cohort studies. Pooled relative risks (RR) and 95% confidence intervals (95% CI) were calculated using the
fixed- and random-effects model. Fourteen population-based studies (4 cohort and 10 case-control studies) with a total of
3,040 pancreatic cancer cases fulfilled our inclusion criteria. A history of allergy was associated with a reduced risk of
pancreatic cancer (RR, 0.82; 95% CI, 0.68-0.99). The risk reduction was stronger for allergies related to atopy (RR, 0.71;
95% CI, 0.64-0.80), but not for asthma (RR, 1.01; 95% CI, 0.77-1.31). There was no association between allergies related to
food or drugs and pancreatic cancer (RR, 1.08; 95% CI, 0.74-1.58). Overall, there was no evidence of publication bias. Allergies,
in particular those related to atopy, seem to be associated with a decreased risk of pancreatic cancer. The hyperactive immune
system of allergic individuals may, therefore, in some way lead to increased surveillance and protect against pancreatic cancer
development. |
| doi_str_mv | 10.1158/1055-9965.EPI-05-0119 |
| format | Article |
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history of allergy and pancreatic cancer risk has not been well studied. We did a systematic review and meta-analysis of published
studies to evaluate the association of any type, and specific types, of allergy and the risk of pancreatic cancer. We did
a comprehensive literature search using MEDLINE, PUBMED, and the ISI Web of Science databases to identify potential relevant
case-control and cohort studies. Pooled relative risks (RR) and 95% confidence intervals (95% CI) were calculated using the
fixed- and random-effects model. Fourteen population-based studies (4 cohort and 10 case-control studies) with a total of
3,040 pancreatic cancer cases fulfilled our inclusion criteria. A history of allergy was associated with a reduced risk of
pancreatic cancer (RR, 0.82; 95% CI, 0.68-0.99). The risk reduction was stronger for allergies related to atopy (RR, 0.71;
95% CI, 0.64-0.80), but not for asthma (RR, 1.01; 95% CI, 0.77-1.31). There was no association between allergies related to
food or drugs and pancreatic cancer (RR, 1.08; 95% CI, 0.74-1.58). Overall, there was no evidence of publication bias. Allergies,
in particular those related to atopy, seem to be associated with a decreased risk of pancreatic cancer. The hyperactive immune
system of allergic individuals may, therefore, in some way lead to increased surveillance and protect against pancreatic cancer
development.</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>DOI: 10.1158/1055-9965.EPI-05-0119</identifier><identifier>PMID: 16103436</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>allergy ; atopy ; Biological and medical sciences ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Hypersensitivity - complications ; Hypersensitivity - immunology ; immunosurveillance ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; meta-analysis ; Pancreas cancer ; Pancreatic Neoplasms - etiology ; Pancreatic Neoplasms - immunology ; Risk ; Tumors</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2005-08, Vol.14 (8), p.1908-1916</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-7638a079c7b378e22fb06f20a550bd5ca0ee40d86b4092e3f8451bd3ebac7dda3</citedby><cites>FETCH-LOGICAL-c422t-7638a079c7b378e22fb06f20a550bd5ca0ee40d86b4092e3f8451bd3ebac7dda3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3356,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17020943$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16103436$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GANDINI, Sara</creatorcontrib><creatorcontrib>LOWENFELS, Albert B</creatorcontrib><creatorcontrib>JAFFEE, Elizabeth M</creatorcontrib><creatorcontrib>ARMSTRONG, Todd D</creatorcontrib><creatorcontrib>MAISONNEUVE, Patrick</creatorcontrib><title>Allergies and the Risk of Pancreatic Cancer: A Meta-analysis with Review of Epidemiology and Biological Mechanisms</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>Previous reports suggest that allergic disorders may protect against various types of cancer, but the association between
history of allergy and pancreatic cancer risk has not been well studied. We did a systematic review and meta-analysis of published
studies to evaluate the association of any type, and specific types, of allergy and the risk of pancreatic cancer. We did
a comprehensive literature search using MEDLINE, PUBMED, and the ISI Web of Science databases to identify potential relevant
case-control and cohort studies. Pooled relative risks (RR) and 95% confidence intervals (95% CI) were calculated using the
fixed- and random-effects model. Fourteen population-based studies (4 cohort and 10 case-control studies) with a total of
3,040 pancreatic cancer cases fulfilled our inclusion criteria. A history of allergy was associated with a reduced risk of
pancreatic cancer (RR, 0.82; 95% CI, 0.68-0.99). The risk reduction was stronger for allergies related to atopy (RR, 0.71;
95% CI, 0.64-0.80), but not for asthma (RR, 1.01; 95% CI, 0.77-1.31). There was no association between allergies related to
food or drugs and pancreatic cancer (RR, 1.08; 95% CI, 0.74-1.58). Overall, there was no evidence of publication bias. Allergies,
in particular those related to atopy, seem to be associated with a decreased risk of pancreatic cancer. The hyperactive immune
system of allergic individuals may, therefore, in some way lead to increased surveillance and protect against pancreatic cancer
development.</description><subject>allergy</subject><subject>atopy</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Hypersensitivity - complications</subject><subject>Hypersensitivity - immunology</subject><subject>immunosurveillance</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>meta-analysis</subject><subject>Pancreas cancer</subject><subject>Pancreatic Neoplasms - etiology</subject><subject>Pancreatic Neoplasms - immunology</subject><subject>Risk</subject><subject>Tumors</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1v1DAQhiMEoqXwE0C-UHFJGcd2nHBbVttSqYiqas_WxJlsDPlY7GxX--9xdhf1NO_heWdGT5J85HDFuSq-clAqLctcXa3ub1NQKXBevkrOuRJFqrVSr2P-z5wl70L4DQC6VOptcsZzDkKK_Dzxi64jv3YUGA41m1piDy78YWPD7nGwnnByli1jJP-NLdhPmjDFAbt9cIHt3NSyB3p2tJsbq42rqXdjN673h3XfD9lZ7GLRtji40If3yZsGu0AfTvMiebpePS5_pHe_bm6Xi7vUyiybUp2LAuPDVldCF5RlTQV5kwEqBVWtLAKRhLrIKwllRqIppOJVLahCq-saxUVyedy78ePfLYXJ9C5Y6jocaNwGkxdSl1pmEVRH0PoxBE-N2XjXo98bDmaWbWaRZhZpomwDysyyY-_T6cC26ql-aZ3sRuDzCcAQHTQ-anThhdOQQSlF5L4cudat253zZOxBuKdA6G1ruDTxiRIK8Q8RlpZk</recordid><startdate>20050801</startdate><enddate>20050801</enddate><creator>GANDINI, Sara</creator><creator>LOWENFELS, Albert B</creator><creator>JAFFEE, Elizabeth M</creator><creator>ARMSTRONG, Todd D</creator><creator>MAISONNEUVE, Patrick</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050801</creationdate><title>Allergies and the Risk of Pancreatic Cancer: A Meta-analysis with Review of Epidemiology and Biological Mechanisms</title><author>GANDINI, Sara ; LOWENFELS, Albert B ; JAFFEE, Elizabeth M ; ARMSTRONG, Todd D ; MAISONNEUVE, Patrick</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-7638a079c7b378e22fb06f20a550bd5ca0ee40d86b4092e3f8451bd3ebac7dda3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>allergy</topic><topic>atopy</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Hypersensitivity - complications</topic><topic>Hypersensitivity - immunology</topic><topic>immunosurveillance</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>meta-analysis</topic><topic>Pancreas cancer</topic><topic>Pancreatic Neoplasms - etiology</topic><topic>Pancreatic Neoplasms - immunology</topic><topic>Risk</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GANDINI, Sara</creatorcontrib><creatorcontrib>LOWENFELS, Albert B</creatorcontrib><creatorcontrib>JAFFEE, Elizabeth M</creatorcontrib><creatorcontrib>ARMSTRONG, Todd D</creatorcontrib><creatorcontrib>MAISONNEUVE, Patrick</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GANDINI, Sara</au><au>LOWENFELS, Albert B</au><au>JAFFEE, Elizabeth M</au><au>ARMSTRONG, Todd D</au><au>MAISONNEUVE, Patrick</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Allergies and the Risk of Pancreatic Cancer: A Meta-analysis with Review of Epidemiology and Biological Mechanisms</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2005-08-01</date><risdate>2005</risdate><volume>14</volume><issue>8</issue><spage>1908</spage><epage>1916</epage><pages>1908-1916</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><abstract>Previous reports suggest that allergic disorders may protect against various types of cancer, but the association between
history of allergy and pancreatic cancer risk has not been well studied. We did a systematic review and meta-analysis of published
studies to evaluate the association of any type, and specific types, of allergy and the risk of pancreatic cancer. We did
a comprehensive literature search using MEDLINE, PUBMED, and the ISI Web of Science databases to identify potential relevant
case-control and cohort studies. Pooled relative risks (RR) and 95% confidence intervals (95% CI) were calculated using the
fixed- and random-effects model. Fourteen population-based studies (4 cohort and 10 case-control studies) with a total of
3,040 pancreatic cancer cases fulfilled our inclusion criteria. A history of allergy was associated with a reduced risk of
pancreatic cancer (RR, 0.82; 95% CI, 0.68-0.99). The risk reduction was stronger for allergies related to atopy (RR, 0.71;
95% CI, 0.64-0.80), but not for asthma (RR, 1.01; 95% CI, 0.77-1.31). There was no association between allergies related to
food or drugs and pancreatic cancer (RR, 1.08; 95% CI, 0.74-1.58). Overall, there was no evidence of publication bias. Allergies,
in particular those related to atopy, seem to be associated with a decreased risk of pancreatic cancer. The hyperactive immune
system of allergic individuals may, therefore, in some way lead to increased surveillance and protect against pancreatic cancer
development.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>16103436</pmid><doi>10.1158/1055-9965.EPI-05-0119</doi><tpages>9</tpages></addata></record> |
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| ispartof | Cancer epidemiology, biomarkers & prevention, 2005-08, Vol.14 (8), p.1908-1916 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; American Association for Cancer Research |
| subjects | allergy atopy Biological and medical sciences Female Gastroenterology. Liver. Pancreas. Abdomen Humans Hypersensitivity - complications Hypersensitivity - immunology immunosurveillance Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences meta-analysis Pancreas cancer Pancreatic Neoplasms - etiology Pancreatic Neoplasms - immunology Risk Tumors |
| title | Allergies and the Risk of Pancreatic Cancer: A Meta-analysis with Review of Epidemiology and Biological Mechanisms |
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