Role of phospholipase A2 (group I secreted) in the genesis of basal tone in the internal anal sphincter smooth muscle

The role of phospholipase A(2) (PLA(2)) in the genesis of basal tone in the internal anal sphincter (IAS) is not known. We determined the effects of PLA(2) and inhibitors on the basal tone and intraluminal pressures (IASP) in the rat IAS vs. rectal smooth muscles (RSM). In addition, we determined th...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2007-11, Vol.293 (5), p.G979-G986
Hauptverfasser:	de Godoy, Márcio A F, Rattan, Satish
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonic Acids - pharmacology Enzyme Inhibitors - pharmacology Male Muscle Tonus - physiology Muscle, Smooth - physiology Phospholipase A2 Inhibitors Phospholipases A2 - genetics Phospholipases A2 - physiology Rats Rats, Sprague-Dawley Rectum - physiology RNA, Messenger - genetics
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