Dyspnea, Ventilatory Pattern, and Changes in Dynamic Hyperinflation Related to the Intensity of Constant Work Rate Exercise in COPD
We undertook the present study to investigate the perception of dyspnea (with respect to changes in end-inspiratory and end-expiratory lung volumes), during four different levels of high-intensity constant work rate exercise (CWRE) in patients with severe COPD Crossover descriptive study with consec...
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| Veröffentlicht in: | Chest 2005-08, Vol.128 (2), p.651-656 |
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| creator | Puente-Maestu, Luis García de Pedro, Julia Martínez-Abad, Yolanda Ruíz de Oña, José Maria Llorente, Daniel Cubillo, José Manuel |
| description | We undertook the present study to investigate the perception of dyspnea (with respect to changes in end-inspiratory and end-expiratory lung volumes), during four different levels of high-intensity constant work rate exercise (CWRE) in patients with severe COPD
Crossover descriptive study with consecutively recruited subjects
Tertiary university hospital
Twenty-seven subjects with severe COPD (mean [± SD] age, 65 ± 5 years of age; mean FEV1, 43 ± 8% predicted; and mean inspiratory capacity [IC]; 74 ± 14% predicted)
Subjects randomly performed four high-intensity CWRE tests (conducted at 65%, 75%, 85%, and 95% of their symptom-limited peak work rate). Dyspnea, leg fatigue, and IC were determined every 2 min during exercise with breath-by-breath gas exchange and ventilatory measurements. There was a good correlation between the resting IC percent predicted and the oxygen uptake ( V.o2) peak (r= 0.64 to 0.69 between the IC percent predicted and V.o2peak at the four work rates). There were significant differences (p < 0.01) in mean respiratory rate (33 ± 6, 35 ± 6, 37 ± 6, and 38 ± 6 min), peak dyspnea score (5.9 ± 1.3, 6.3 ± 1.4, 6.8 ± 1.2, and 6.9 ± 1.6), minute ventilation (45.0 ± 8.7, 43.8 ± 7.7, 43.1 ± 8.7, and 42.8 ± 8.0 L/min), leg fatigue (4.8 ± 1.3, 5.1 ± 1.3, 5.7 ± 1.4, and 5.8 ± 1.4), and end-tidal carbon dioxide partial pressure (4.41 ± 0.36, 4.53 ± 0.33, 4.66 ± 0.31, and 4.76 ± 0.24 kPa), respectively, for tests conducted at 65%, 75%, 85%, and 95% of their symptom-limited peak work rate, and in mean end-expiratory lung volume ([EELV] 4.55 ± 0.44, 4.69 ± 0.43, and 4.79 ± 0.43 L), respectively, for tests conducted at 65%, 75%, and 85% of their symptom-limited peak work rate. In multivariable analysis, the factors that were independently correlated with dyspnea (p < 0.05) were EELV, peak inspiratory flow, and leg fatigue/discomfort
In COPD subjects with flow limitation at rest, the perception of dyspnea increased nonlinearly with the magnitude of high-intensity CWRE in association with a faster respiratory pattern and an increase in EELV. At the highest work rates, it appeared that a reduction in tidal volume and ventilation peak may have limited the tolerance to exercise |
| doi_str_mv | 10.1378/chest.128.2.651 |
| format | Article |
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Crossover descriptive study with consecutively recruited subjects
Tertiary university hospital
Twenty-seven subjects with severe COPD (mean [± SD] age, 65 ± 5 years of age; mean FEV1, 43 ± 8% predicted; and mean inspiratory capacity [IC]; 74 ± 14% predicted)
Subjects randomly performed four high-intensity CWRE tests (conducted at 65%, 75%, 85%, and 95% of their symptom-limited peak work rate). Dyspnea, leg fatigue, and IC were determined every 2 min during exercise with breath-by-breath gas exchange and ventilatory measurements. There was a good correlation between the resting IC percent predicted and the oxygen uptake ( V.o2) peak (r= 0.64 to 0.69 between the IC percent predicted and V.o2peak at the four work rates). There were significant differences (p < 0.01) in mean respiratory rate (33 ± 6, 35 ± 6, 37 ± 6, and 38 ± 6 min), peak dyspnea score (5.9 ± 1.3, 6.3 ± 1.4, 6.8 ± 1.2, and 6.9 ± 1.6), minute ventilation (45.0 ± 8.7, 43.8 ± 7.7, 43.1 ± 8.7, and 42.8 ± 8.0 L/min), leg fatigue (4.8 ± 1.3, 5.1 ± 1.3, 5.7 ± 1.4, and 5.8 ± 1.4), and end-tidal carbon dioxide partial pressure (4.41 ± 0.36, 4.53 ± 0.33, 4.66 ± 0.31, and 4.76 ± 0.24 kPa), respectively, for tests conducted at 65%, 75%, 85%, and 95% of their symptom-limited peak work rate, and in mean end-expiratory lung volume ([EELV] 4.55 ± 0.44, 4.69 ± 0.43, and 4.79 ± 0.43 L), respectively, for tests conducted at 65%, 75%, and 85% of their symptom-limited peak work rate. In multivariable analysis, the factors that were independently correlated with dyspnea (p < 0.05) were EELV, peak inspiratory flow, and leg fatigue/discomfort
In COPD subjects with flow limitation at rest, the perception of dyspnea increased nonlinearly with the magnitude of high-intensity CWRE in association with a faster respiratory pattern and an increase in EELV. At the highest work rates, it appeared that a reduction in tidal volume and ventilation peak may have limited the tolerance to exercise</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.128.2.651</identifier><identifier>PMID: 16100150</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>Northbrook, IL: Elsevier Inc</publisher><subject>Aged ; Biological and medical sciences ; Carbon dioxide ; Cardiology. Vascular system ; Care and treatment ; Chronic obstructive pulmonary disease ; constant work rate exercise ; COPD ; Cross-Over Studies ; dynamic hyperinflation ; Dyspnea ; Dyspnea - physiopathology ; Exercise ; flow limitation ; Health aspects ; Humans ; Lung diseases, Obstructive ; Medical sciences ; Patients ; Physical fitness ; Pneumology ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Pulmonary Ventilation ; Respiratory system : syndromes and miscellaneous diseases ; Severity of Illness Index ; Shortness of breath ; Ventilation ; ventilatory pattern</subject><ispartof>Chest, 2005-08, Vol.128 (2), p.651-656</ispartof><rights>2005 The American College of Chest Physicians</rights><rights>2005 INIST-CNRS</rights><rights>COPYRIGHT 2005 Elsevier B.V.</rights><rights>Copyright American College of Chest Physicians Aug 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c585t-654eaf52624a56c71c91fb16817c0ae3eec3d52866fc95550c6ed558220a45c23</citedby><cites>FETCH-LOGICAL-c585t-654eaf52624a56c71c91fb16817c0ae3eec3d52866fc95550c6ed558220a45c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17019112$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16100150$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Puente-Maestu, Luis</creatorcontrib><creatorcontrib>García de Pedro, Julia</creatorcontrib><creatorcontrib>Martínez-Abad, Yolanda</creatorcontrib><creatorcontrib>Ruíz de Oña, José Maria</creatorcontrib><creatorcontrib>Llorente, Daniel</creatorcontrib><creatorcontrib>Cubillo, José Manuel</creatorcontrib><title>Dyspnea, Ventilatory Pattern, and Changes in Dynamic Hyperinflation Related to the Intensity of Constant Work Rate Exercise in COPD</title><title>Chest</title><addtitle>Chest</addtitle><description>We undertook the present study to investigate the perception of dyspnea (with respect to changes in end-inspiratory and end-expiratory lung volumes), during four different levels of high-intensity constant work rate exercise (CWRE) in patients with severe COPD
Crossover descriptive study with consecutively recruited subjects
Tertiary university hospital
Twenty-seven subjects with severe COPD (mean [± SD] age, 65 ± 5 years of age; mean FEV1, 43 ± 8% predicted; and mean inspiratory capacity [IC]; 74 ± 14% predicted)
Subjects randomly performed four high-intensity CWRE tests (conducted at 65%, 75%, 85%, and 95% of their symptom-limited peak work rate). Dyspnea, leg fatigue, and IC were determined every 2 min during exercise with breath-by-breath gas exchange and ventilatory measurements. There was a good correlation between the resting IC percent predicted and the oxygen uptake ( V.o2) peak (r= 0.64 to 0.69 between the IC percent predicted and V.o2peak at the four work rates). There were significant differences (p < 0.01) in mean respiratory rate (33 ± 6, 35 ± 6, 37 ± 6, and 38 ± 6 min), peak dyspnea score (5.9 ± 1.3, 6.3 ± 1.4, 6.8 ± 1.2, and 6.9 ± 1.6), minute ventilation (45.0 ± 8.7, 43.8 ± 7.7, 43.1 ± 8.7, and 42.8 ± 8.0 L/min), leg fatigue (4.8 ± 1.3, 5.1 ± 1.3, 5.7 ± 1.4, and 5.8 ± 1.4), and end-tidal carbon dioxide partial pressure (4.41 ± 0.36, 4.53 ± 0.33, 4.66 ± 0.31, and 4.76 ± 0.24 kPa), respectively, for tests conducted at 65%, 75%, 85%, and 95% of their symptom-limited peak work rate, and in mean end-expiratory lung volume ([EELV] 4.55 ± 0.44, 4.69 ± 0.43, and 4.79 ± 0.43 L), respectively, for tests conducted at 65%, 75%, and 85% of their symptom-limited peak work rate. In multivariable analysis, the factors that were independently correlated with dyspnea (p < 0.05) were EELV, peak inspiratory flow, and leg fatigue/discomfort
In COPD subjects with flow limitation at rest, the perception of dyspnea increased nonlinearly with the magnitude of high-intensity CWRE in association with a faster respiratory pattern and an increase in EELV. At the highest work rates, it appeared that a reduction in tidal volume and ventilation peak may have limited the tolerance to exercise</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Carbon dioxide</subject><subject>Cardiology. Vascular system</subject><subject>Care and treatment</subject><subject>Chronic obstructive pulmonary disease</subject><subject>constant work rate exercise</subject><subject>COPD</subject><subject>Cross-Over Studies</subject><subject>dynamic hyperinflation</subject><subject>Dyspnea</subject><subject>Dyspnea - physiopathology</subject><subject>Exercise</subject><subject>flow limitation</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Lung diseases, Obstructive</subject><subject>Medical sciences</subject><subject>Patients</subject><subject>Physical fitness</subject><subject>Pneumology</subject><subject>Pulmonary Disease, Chronic Obstructive - physiopathology</subject><subject>Pulmonary Ventilation</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Severity of Illness Index</subject><subject>Shortness of breath</subject><subject>Ventilation</subject><subject>ventilatory pattern</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kc1vEzEQxVcIRNPCmRuykODUTf2xdnaP1abQSpVaVXwcLdc7m7hs7NR2oHvmH2dKIgWhIh88tn5vZvReUbxhdMrErD6xS0h5yng95VMl2bNiwhrBSiEr8byYUMp4KVTDD4rDlO4ovlmjXhYHTDGsJZ0Uv-ZjWnswx-Qr-OwGk0McybXJGaI_JsZ3pF0av4BEnCfz0ZuVs-R8XEN0vkfcBU9uAAvoSA4kL4Fc-Aw-uTyS0JM2-JSNz-RbiN_JDXLk7AGidQkeO7ZX1_NXxYveDAle7-6j4svHs8_teXl59emiPb0sraxlLpWswPSSK14ZqeyM2Yb1t0zVbGapAQFgRSd5rVRvGykltQo6KWvOqamk5eKo-LDtu47hfoPG6ZVLFobBeAibpFVdzWpZMQTf_QPehU30uJvmlFaSciEQKrfQwgyg0YyQo7EL8BDNEDz0Dr9PmZAKzZYK-ekTPJ4O0NInBSdbgY0hpQi9Xke3MnHUjOrH9PWf9DWmr7nG9FHxdrf35nYF3Z7fxY3A-x1gkjVDH43HIPbcjLKGMb4fvXSL5U8XQaeVGQZsK7ZDd378PbrZKgAD_OEg6mQdeAsdqm3WXXD_Xfs3arfbzw</recordid><startdate>20050801</startdate><enddate>20050801</enddate><creator>Puente-Maestu, Luis</creator><creator>García de Pedro, Julia</creator><creator>Martínez-Abad, Yolanda</creator><creator>Ruíz de Oña, José Maria</creator><creator>Llorente, Daniel</creator><creator>Cubillo, José Manuel</creator><general>Elsevier Inc</general><general>American College of Chest Physicians</general><general>Elsevier B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20050801</creationdate><title>Dyspnea, Ventilatory Pattern, and Changes in Dynamic Hyperinflation Related to the Intensity of Constant Work Rate Exercise in COPD</title><author>Puente-Maestu, Luis ; García de Pedro, Julia ; Martínez-Abad, Yolanda ; Ruíz de Oña, José Maria ; Llorente, Daniel ; Cubillo, José Manuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c585t-654eaf52624a56c71c91fb16817c0ae3eec3d52866fc95550c6ed558220a45c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Carbon dioxide</topic><topic>Cardiology. Vascular system</topic><topic>Care and treatment</topic><topic>Chronic obstructive pulmonary disease</topic><topic>constant work rate exercise</topic><topic>COPD</topic><topic>Cross-Over Studies</topic><topic>dynamic hyperinflation</topic><topic>Dyspnea</topic><topic>Dyspnea - physiopathology</topic><topic>Exercise</topic><topic>flow limitation</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Lung diseases, Obstructive</topic><topic>Medical sciences</topic><topic>Patients</topic><topic>Physical fitness</topic><topic>Pneumology</topic><topic>Pulmonary Disease, Chronic Obstructive - physiopathology</topic><topic>Pulmonary Ventilation</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>Severity of Illness Index</topic><topic>Shortness of breath</topic><topic>Ventilation</topic><topic>ventilatory pattern</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Puente-Maestu, Luis</creatorcontrib><creatorcontrib>García de Pedro, Julia</creatorcontrib><creatorcontrib>Martínez-Abad, Yolanda</creatorcontrib><creatorcontrib>Ruíz de Oña, José Maria</creatorcontrib><creatorcontrib>Llorente, Daniel</creatorcontrib><creatorcontrib>Cubillo, José Manuel</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Puente-Maestu, Luis</au><au>García de Pedro, Julia</au><au>Martínez-Abad, Yolanda</au><au>Ruíz de Oña, José Maria</au><au>Llorente, Daniel</au><au>Cubillo, José Manuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dyspnea, Ventilatory Pattern, and Changes in Dynamic Hyperinflation Related to the Intensity of Constant Work Rate Exercise in COPD</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>2005-08-01</date><risdate>2005</risdate><volume>128</volume><issue>2</issue><spage>651</spage><epage>656</epage><pages>651-656</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract>We undertook the present study to investigate the perception of dyspnea (with respect to changes in end-inspiratory and end-expiratory lung volumes), during four different levels of high-intensity constant work rate exercise (CWRE) in patients with severe COPD
Crossover descriptive study with consecutively recruited subjects
Tertiary university hospital
Twenty-seven subjects with severe COPD (mean [± SD] age, 65 ± 5 years of age; mean FEV1, 43 ± 8% predicted; and mean inspiratory capacity [IC]; 74 ± 14% predicted)
Subjects randomly performed four high-intensity CWRE tests (conducted at 65%, 75%, 85%, and 95% of their symptom-limited peak work rate). Dyspnea, leg fatigue, and IC were determined every 2 min during exercise with breath-by-breath gas exchange and ventilatory measurements. There was a good correlation between the resting IC percent predicted and the oxygen uptake ( V.o2) peak (r= 0.64 to 0.69 between the IC percent predicted and V.o2peak at the four work rates). There were significant differences (p < 0.01) in mean respiratory rate (33 ± 6, 35 ± 6, 37 ± 6, and 38 ± 6 min), peak dyspnea score (5.9 ± 1.3, 6.3 ± 1.4, 6.8 ± 1.2, and 6.9 ± 1.6), minute ventilation (45.0 ± 8.7, 43.8 ± 7.7, 43.1 ± 8.7, and 42.8 ± 8.0 L/min), leg fatigue (4.8 ± 1.3, 5.1 ± 1.3, 5.7 ± 1.4, and 5.8 ± 1.4), and end-tidal carbon dioxide partial pressure (4.41 ± 0.36, 4.53 ± 0.33, 4.66 ± 0.31, and 4.76 ± 0.24 kPa), respectively, for tests conducted at 65%, 75%, 85%, and 95% of their symptom-limited peak work rate, and in mean end-expiratory lung volume ([EELV] 4.55 ± 0.44, 4.69 ± 0.43, and 4.79 ± 0.43 L), respectively, for tests conducted at 65%, 75%, and 85% of their symptom-limited peak work rate. In multivariable analysis, the factors that were independently correlated with dyspnea (p < 0.05) were EELV, peak inspiratory flow, and leg fatigue/discomfort
In COPD subjects with flow limitation at rest, the perception of dyspnea increased nonlinearly with the magnitude of high-intensity CWRE in association with a faster respiratory pattern and an increase in EELV. At the highest work rates, it appeared that a reduction in tidal volume and ventilation peak may have limited the tolerance to exercise</abstract><cop>Northbrook, IL</cop><pub>Elsevier Inc</pub><pmid>16100150</pmid><doi>10.1378/chest.128.2.651</doi><tpages>6</tpages></addata></record> |
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| subjects | Aged Biological and medical sciences Carbon dioxide Cardiology. Vascular system Care and treatment Chronic obstructive pulmonary disease constant work rate exercise COPD Cross-Over Studies dynamic hyperinflation Dyspnea Dyspnea - physiopathology Exercise flow limitation Health aspects Humans Lung diseases, Obstructive Medical sciences Patients Physical fitness Pneumology Pulmonary Disease, Chronic Obstructive - physiopathology Pulmonary Ventilation Respiratory system : syndromes and miscellaneous diseases Severity of Illness Index Shortness of breath Ventilation ventilatory pattern |
| title | Dyspnea, Ventilatory Pattern, and Changes in Dynamic Hyperinflation Related to the Intensity of Constant Work Rate Exercise in COPD |
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