The international HIV dementia scale : a new rapid screening test for HIV dementia
HIV dementia is an important neurological complication of advanced HIV infection. The use of a cross-cultural screening test to detect HIV dementia within the international community is critical for diagnosing this condition. The objective of this study was to evaluate the sensitivity and specificit...
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| Veröffentlicht in: | AIDS (London) 2005-09, Vol.19 (13), p.1367-1374 |
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| creator | SACKTOR, Ned C WONG, Matthew NAKASUJJA, Noeline SKOLASKY, Richard L SELNES, Ola A MUSISI, Seggane ROBERTSON, Kevin MCARTHUR, Justin C RONALD, Allan KATABIRA, Elly |
| description | HIV dementia is an important neurological complication of advanced HIV infection. The use of a cross-cultural screening test to detect HIV dementia within the international community is critical for diagnosing this condition. The objective of this study was to evaluate the sensitivity and specificity of a new screening test for HIV dementia, the International HIV Dementia Scale (IHDS) in cohorts from the US and Uganda.
Two cross-sectional cohort studies designed to evaluate for the presence of HIV dementia.
Sixty-six HIV-positive individuals in the US and 81 HIV-positive individuals in Uganda received the IHDS and full standardized neurological and neuropsychological assessments. The sensitivity and specificity of varying cut-off scores of the IHDS were evaluated in the two cohorts.
In the US cohort, the mean IHDS score for HIV-positive individuals without dementia and with dementia were 10.6 and 9.3 respectively (P < 0.001). Using the cut-off of < or = 10, the sensitivity and specificity for HIV dementia with the IHDS were 80% and 57% respectively in the US cohort, and 80% and 55% respectively in the Uganda cohort.
The IHDS may be a useful screening test to identify individuals at risk for HIV dementia in both the industrialized world and the developing world. Full neuropsychological testing should then be performed to confirm a diagnosis of HIV dementia. |
| format | Article |
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Two cross-sectional cohort studies designed to evaluate for the presence of HIV dementia.
Sixty-six HIV-positive individuals in the US and 81 HIV-positive individuals in Uganda received the IHDS and full standardized neurological and neuropsychological assessments. The sensitivity and specificity of varying cut-off scores of the IHDS were evaluated in the two cohorts.
In the US cohort, the mean IHDS score for HIV-positive individuals without dementia and with dementia were 10.6 and 9.3 respectively (P < 0.001). Using the cut-off of < or = 10, the sensitivity and specificity for HIV dementia with the IHDS were 80% and 57% respectively in the US cohort, and 80% and 55% respectively in the Uganda cohort.
The IHDS may be a useful screening test to identify individuals at risk for HIV dementia in both the industrialized world and the developing world. Full neuropsychological testing should then be performed to confirm a diagnosis of HIV dementia.</description><identifier>ISSN: 0269-9370</identifier><identifier>EISSN: 1473-5571</identifier><identifier>PMID: 16103767</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Aged ; AIDS Dementia Complex - diagnosis ; AIDS Dementia Complex - physiopathology ; AIDS Dementia Complex - psychology ; AIDS/HIV ; Biological and medical sciences ; Cross-Cultural Comparison ; Developing Countries ; Human viral diseases ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infectious diseases ; Mass Screening - methods ; Medical sciences ; Mental Recall ; Middle Aged ; Neuropsychological Tests ; Psychometrics ; Psychomotor Performance ; Sensitivity and Specificity ; Uganda ; United States ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids</subject><ispartof>AIDS (London), 2005-09, Vol.19 (13), p.1367-1374</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17334997$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16103767$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SACKTOR, Ned C</creatorcontrib><creatorcontrib>WONG, Matthew</creatorcontrib><creatorcontrib>NAKASUJJA, Noeline</creatorcontrib><creatorcontrib>SKOLASKY, Richard L</creatorcontrib><creatorcontrib>SELNES, Ola A</creatorcontrib><creatorcontrib>MUSISI, Seggane</creatorcontrib><creatorcontrib>ROBERTSON, Kevin</creatorcontrib><creatorcontrib>MCARTHUR, Justin C</creatorcontrib><creatorcontrib>RONALD, Allan</creatorcontrib><creatorcontrib>KATABIRA, Elly</creatorcontrib><title>The international HIV dementia scale : a new rapid screening test for HIV dementia</title><title>AIDS (London)</title><addtitle>AIDS</addtitle><description>HIV dementia is an important neurological complication of advanced HIV infection. The use of a cross-cultural screening test to detect HIV dementia within the international community is critical for diagnosing this condition. The objective of this study was to evaluate the sensitivity and specificity of a new screening test for HIV dementia, the International HIV Dementia Scale (IHDS) in cohorts from the US and Uganda.
Two cross-sectional cohort studies designed to evaluate for the presence of HIV dementia.
Sixty-six HIV-positive individuals in the US and 81 HIV-positive individuals in Uganda received the IHDS and full standardized neurological and neuropsychological assessments. The sensitivity and specificity of varying cut-off scores of the IHDS were evaluated in the two cohorts.
In the US cohort, the mean IHDS score for HIV-positive individuals without dementia and with dementia were 10.6 and 9.3 respectively (P < 0.001). Using the cut-off of < or = 10, the sensitivity and specificity for HIV dementia with the IHDS were 80% and 57% respectively in the US cohort, and 80% and 55% respectively in the Uganda cohort.
The IHDS may be a useful screening test to identify individuals at risk for HIV dementia in both the industrialized world and the developing world. Full neuropsychological testing should then be performed to confirm a diagnosis of HIV dementia.</description><subject>Adult</subject><subject>Aged</subject><subject>AIDS Dementia Complex - diagnosis</subject><subject>AIDS Dementia Complex - physiopathology</subject><subject>AIDS Dementia Complex - psychology</subject><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Cross-Cultural Comparison</subject><subject>Developing Countries</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Infectious diseases</subject><subject>Mass Screening - methods</subject><subject>Medical sciences</subject><subject>Mental Recall</subject><subject>Middle Aged</subject><subject>Neuropsychological Tests</subject><subject>Psychometrics</subject><subject>Psychomotor Performance</subject><subject>Sensitivity and Specificity</subject><subject>Uganda</subject><subject>United States</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><issn>0269-9370</issn><issn>1473-5571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0MFKxDAQBuAgiruuvoLkordC2jRJ400WdRcWBFm9ltlkopE2rUmL-PZWXBFPngaG7x-G_4DM81LxTAiVH5I5K6TONFdsRk5SemWMCVZVx2SWy5xxJdWcPGxfkPowYAww-C5AQ1frJ2qxxTB4oMlAg_SKAg34TiP03k67iBh8eKYDpoG6Lv7JnJIjB03Cs_1ckMfbm-1ylW3u79bL603WF4oNmZXWCeMMqkoyLHNeWLszjjFnKitMabTaoXIaUEtuCo4SHdcMhGUKjLN8QS6_7_axexunT-rWJ4NNAwG7MdWyKpXgovoX5kpKnjM5wfM9HHct2rqPvoX4Uf_UNYGLPYCvYlyEYHz6dYrzUmvFPwFvz3SV</recordid><startdate>20050902</startdate><enddate>20050902</enddate><creator>SACKTOR, Ned C</creator><creator>WONG, Matthew</creator><creator>NAKASUJJA, Noeline</creator><creator>SKOLASKY, Richard L</creator><creator>SELNES, Ola A</creator><creator>MUSISI, Seggane</creator><creator>ROBERTSON, Kevin</creator><creator>MCARTHUR, Justin C</creator><creator>RONALD, Allan</creator><creator>KATABIRA, Elly</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20050902</creationdate><title>The international HIV dementia scale : a new rapid screening test for HIV dementia</title><author>SACKTOR, Ned C ; WONG, Matthew ; NAKASUJJA, Noeline ; SKOLASKY, Richard L ; SELNES, Ola A ; MUSISI, Seggane ; ROBERTSON, Kevin ; MCARTHUR, Justin C ; RONALD, Allan ; KATABIRA, Elly</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p270t-d6df5cfce7860e4132ddbcf00fc8d5c4c97be7f9ae963c23e6ef390a5d07acfd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>AIDS Dementia Complex - diagnosis</topic><topic>AIDS Dementia Complex - physiopathology</topic><topic>AIDS Dementia Complex - psychology</topic><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>Cross-Cultural Comparison</topic><topic>Developing Countries</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Infectious diseases</topic><topic>Mass Screening - methods</topic><topic>Medical sciences</topic><topic>Mental Recall</topic><topic>Middle Aged</topic><topic>Neuropsychological Tests</topic><topic>Psychometrics</topic><topic>Psychomotor Performance</topic><topic>Sensitivity and Specificity</topic><topic>Uganda</topic><topic>United States</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SACKTOR, Ned C</creatorcontrib><creatorcontrib>WONG, Matthew</creatorcontrib><creatorcontrib>NAKASUJJA, Noeline</creatorcontrib><creatorcontrib>SKOLASKY, Richard L</creatorcontrib><creatorcontrib>SELNES, Ola A</creatorcontrib><creatorcontrib>MUSISI, Seggane</creatorcontrib><creatorcontrib>ROBERTSON, Kevin</creatorcontrib><creatorcontrib>MCARTHUR, Justin C</creatorcontrib><creatorcontrib>RONALD, Allan</creatorcontrib><creatorcontrib>KATABIRA, Elly</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>AIDS (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SACKTOR, Ned C</au><au>WONG, Matthew</au><au>NAKASUJJA, Noeline</au><au>SKOLASKY, Richard L</au><au>SELNES, Ola A</au><au>MUSISI, Seggane</au><au>ROBERTSON, Kevin</au><au>MCARTHUR, Justin C</au><au>RONALD, Allan</au><au>KATABIRA, Elly</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The international HIV dementia scale : a new rapid screening test for HIV dementia</atitle><jtitle>AIDS (London)</jtitle><addtitle>AIDS</addtitle><date>2005-09-02</date><risdate>2005</risdate><volume>19</volume><issue>13</issue><spage>1367</spage><epage>1374</epage><pages>1367-1374</pages><issn>0269-9370</issn><eissn>1473-5571</eissn><abstract>HIV dementia is an important neurological complication of advanced HIV infection. The use of a cross-cultural screening test to detect HIV dementia within the international community is critical for diagnosing this condition. The objective of this study was to evaluate the sensitivity and specificity of a new screening test for HIV dementia, the International HIV Dementia Scale (IHDS) in cohorts from the US and Uganda.
Two cross-sectional cohort studies designed to evaluate for the presence of HIV dementia.
Sixty-six HIV-positive individuals in the US and 81 HIV-positive individuals in Uganda received the IHDS and full standardized neurological and neuropsychological assessments. The sensitivity and specificity of varying cut-off scores of the IHDS were evaluated in the two cohorts.
In the US cohort, the mean IHDS score for HIV-positive individuals without dementia and with dementia were 10.6 and 9.3 respectively (P < 0.001). Using the cut-off of < or = 10, the sensitivity and specificity for HIV dementia with the IHDS were 80% and 57% respectively in the US cohort, and 80% and 55% respectively in the Uganda cohort.
The IHDS may be a useful screening test to identify individuals at risk for HIV dementia in both the industrialized world and the developing world. Full neuropsychological testing should then be performed to confirm a diagnosis of HIV dementia.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>16103767</pmid><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged AIDS Dementia Complex - diagnosis AIDS Dementia Complex - physiopathology AIDS Dementia Complex - psychology AIDS/HIV Biological and medical sciences Cross-Cultural Comparison Developing Countries Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Mass Screening - methods Medical sciences Mental Recall Middle Aged Neuropsychological Tests Psychometrics Psychomotor Performance Sensitivity and Specificity Uganda United States Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | The international HIV dementia scale : a new rapid screening test for HIV dementia |
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