Novel allele of the endothelial nitric oxide synthase gene polymorphism in Caucasian asthmatics
The purpose of the present study was to investigate an association of the endothelial nitric oxide synthase (eNOS) gene polymorphism with asthma. eNOS intron4 variable number of tandem repeats (27 bp repeats) genotypes were determined in asthma patients and control subjects using microplate PCR. The...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2005-09, Vol.335 (2), p.545-549 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Yanamandra, Krishna Boggs, Peter B. Thurmon, Theodore F. Lewis, David Bocchini, Joseph A. Dhanireddy, Ramasubbareddy |
| description | The purpose of the present study was to investigate an association of the endothelial nitric oxide synthase (eNOS) gene polymorphism with asthma. eNOS intron4 variable number of tandem repeats (27
bp repeats) genotypes were determined in asthma patients and control subjects using microplate PCR. The Caucasian Asthma patients displayed three alleles while Caucasian controls displayed only two alleles. However, African Americans displayed all three alleles in both asthma patients and controls. African American controls displayed significantly higher a allele, significantly lower b allele, as well as c allele than those in Caucasians. This was the first report to show that there was a novel eNOS genotype present in asthmatic patients but not in control subjects in the Caucasian Community. The novel allele which we termed the c allele, could be a significant risk factor in the etiology of asthma in Caucasians. This novel allele could be involved in higher levels of NO in our Caucasian asthmatics. |
| doi_str_mv | 10.1016/j.bbrc.2005.07.108 |
| format | Article |
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bp repeats) genotypes were determined in asthma patients and control subjects using microplate PCR. The Caucasian Asthma patients displayed three alleles while Caucasian controls displayed only two alleles. However, African Americans displayed all three alleles in both asthma patients and controls. African American controls displayed significantly higher a allele, significantly lower b allele, as well as c allele than those in Caucasians. This was the first report to show that there was a novel eNOS genotype present in asthmatic patients but not in control subjects in the Caucasian Community. The novel allele which we termed the c allele, could be a significant risk factor in the etiology of asthma in Caucasians. This novel allele could be involved in higher levels of NO in our Caucasian asthmatics.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2005.07.108</identifier><identifier>PMID: 16081038</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Alleles ; Asthma ; Asthma - ethnology ; Asthma - genetics ; Black or African American ; Black People ; Case-Control Studies ; Caucasians ; DNA - metabolism ; Endothelial nitric oxide synthase ; Gene Frequency ; Genotype ; Humans ; Introns ; Minisatellite Repeats ; Nitric Oxide Synthase - genetics ; Nitric Oxide Synthase Type III ; Novel allele ; Odds Ratio ; Polymorphism, Genetic ; Risk Factors ; Variable number of tandem repeats (27 bp repeats) ; White People</subject><ispartof>Biochemical and biophysical research communications, 2005-09, Vol.335 (2), p.545-549</ispartof><rights>2005 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-74fc8f2b77841fdaaa35a8d15029b2258a6883de749ec9ab9faa4c369104300c3</citedby><cites>FETCH-LOGICAL-c385t-74fc8f2b77841fdaaa35a8d15029b2258a6883de749ec9ab9faa4c369104300c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006291X05015913$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16081038$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yanamandra, Krishna</creatorcontrib><creatorcontrib>Boggs, Peter B.</creatorcontrib><creatorcontrib>Thurmon, Theodore F.</creatorcontrib><creatorcontrib>Lewis, David</creatorcontrib><creatorcontrib>Bocchini, Joseph A.</creatorcontrib><creatorcontrib>Dhanireddy, Ramasubbareddy</creatorcontrib><title>Novel allele of the endothelial nitric oxide synthase gene polymorphism in Caucasian asthmatics</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>The purpose of the present study was to investigate an association of the endothelial nitric oxide synthase (eNOS) gene polymorphism with asthma. eNOS intron4 variable number of tandem repeats (27
bp repeats) genotypes were determined in asthma patients and control subjects using microplate PCR. The Caucasian Asthma patients displayed three alleles while Caucasian controls displayed only two alleles. However, African Americans displayed all three alleles in both asthma patients and controls. African American controls displayed significantly higher a allele, significantly lower b allele, as well as c allele than those in Caucasians. This was the first report to show that there was a novel eNOS genotype present in asthmatic patients but not in control subjects in the Caucasian Community. The novel allele which we termed the c allele, could be a significant risk factor in the etiology of asthma in Caucasians. This novel allele could be involved in higher levels of NO in our Caucasian asthmatics.</description><subject>Alleles</subject><subject>Asthma</subject><subject>Asthma - ethnology</subject><subject>Asthma - genetics</subject><subject>Black or African American</subject><subject>Black People</subject><subject>Case-Control Studies</subject><subject>Caucasians</subject><subject>DNA - metabolism</subject><subject>Endothelial nitric oxide synthase</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>Humans</subject><subject>Introns</subject><subject>Minisatellite Repeats</subject><subject>Nitric Oxide Synthase - genetics</subject><subject>Nitric Oxide Synthase Type III</subject><subject>Novel allele</subject><subject>Odds Ratio</subject><subject>Polymorphism, Genetic</subject><subject>Risk Factors</subject><subject>Variable number of tandem repeats (27 bp repeats)</subject><subject>White People</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2LFDEURYMoTjv6B1xIVu6qffmoqgTcSOOMA4NuHJhdeJV6ZadJVdqkerD_vdV0gztn9eBy7oV3GHsvYC1ANJ92667Lfi0B6jW0S2ZesJUAC5UUoF-yFQA0lbTi8Yq9KWUHIIRu7Gt2JRowApRZMfc9PVHkGCNF4mng85Y4TX1abgwY-RTmHDxPf0JPvByneYuF-C-aiO9TPI4p77ehjDxMfIMHjyXgxLHM2xHn4Mtb9mrAWOjd5V6zh5uvPzffqvsft3ebL_eVV6aeq1YP3gyya1ujxdAjoqrR9KIGaTspa4ONMaqnVlvyFjs7IGqvGrs8qgC8umYfz7v7nH4fqMxuDMVTjDhROhTXGN1qreWzoGiVAaXsAsoz6HMqJdPg9jmMmI9OgDv5dzt38u9O_h20S2aW0ofL-qEbqf9XuQhfgM9ngBYZT4GyKz7Q5KkPmfzs-hT-t_8X9-eXkg</recordid><startdate>20050923</startdate><enddate>20050923</enddate><creator>Yanamandra, Krishna</creator><creator>Boggs, Peter B.</creator><creator>Thurmon, Theodore F.</creator><creator>Lewis, David</creator><creator>Bocchini, Joseph A.</creator><creator>Dhanireddy, Ramasubbareddy</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20050923</creationdate><title>Novel allele of the endothelial nitric oxide synthase gene polymorphism in Caucasian asthmatics</title><author>Yanamandra, Krishna ; Boggs, Peter B. ; Thurmon, Theodore F. ; Lewis, David ; Bocchini, Joseph A. ; Dhanireddy, Ramasubbareddy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-74fc8f2b77841fdaaa35a8d15029b2258a6883de749ec9ab9faa4c369104300c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Alleles</topic><topic>Asthma</topic><topic>Asthma - ethnology</topic><topic>Asthma - genetics</topic><topic>Black or African American</topic><topic>Black People</topic><topic>Case-Control Studies</topic><topic>Caucasians</topic><topic>DNA - metabolism</topic><topic>Endothelial nitric oxide synthase</topic><topic>Gene Frequency</topic><topic>Genotype</topic><topic>Humans</topic><topic>Introns</topic><topic>Minisatellite Repeats</topic><topic>Nitric Oxide Synthase - genetics</topic><topic>Nitric Oxide Synthase Type III</topic><topic>Novel allele</topic><topic>Odds Ratio</topic><topic>Polymorphism, Genetic</topic><topic>Risk Factors</topic><topic>Variable number of tandem repeats (27 bp repeats)</topic><topic>White People</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yanamandra, Krishna</creatorcontrib><creatorcontrib>Boggs, Peter B.</creatorcontrib><creatorcontrib>Thurmon, Theodore F.</creatorcontrib><creatorcontrib>Lewis, David</creatorcontrib><creatorcontrib>Bocchini, Joseph A.</creatorcontrib><creatorcontrib>Dhanireddy, Ramasubbareddy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yanamandra, Krishna</au><au>Boggs, Peter B.</au><au>Thurmon, Theodore F.</au><au>Lewis, David</au><au>Bocchini, Joseph A.</au><au>Dhanireddy, Ramasubbareddy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel allele of the endothelial nitric oxide synthase gene polymorphism in Caucasian asthmatics</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2005-09-23</date><risdate>2005</risdate><volume>335</volume><issue>2</issue><spage>545</spage><epage>549</epage><pages>545-549</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>The purpose of the present study was to investigate an association of the endothelial nitric oxide synthase (eNOS) gene polymorphism with asthma. eNOS intron4 variable number of tandem repeats (27
bp repeats) genotypes were determined in asthma patients and control subjects using microplate PCR. The Caucasian Asthma patients displayed three alleles while Caucasian controls displayed only two alleles. However, African Americans displayed all three alleles in both asthma patients and controls. African American controls displayed significantly higher a allele, significantly lower b allele, as well as c allele than those in Caucasians. This was the first report to show that there was a novel eNOS genotype present in asthmatic patients but not in control subjects in the Caucasian Community. The novel allele which we termed the c allele, could be a significant risk factor in the etiology of asthma in Caucasians. This novel allele could be involved in higher levels of NO in our Caucasian asthmatics.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>16081038</pmid><doi>10.1016/j.bbrc.2005.07.108</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Alleles Asthma Asthma - ethnology Asthma - genetics Black or African American Black People Case-Control Studies Caucasians DNA - metabolism Endothelial nitric oxide synthase Gene Frequency Genotype Humans Introns Minisatellite Repeats Nitric Oxide Synthase - genetics Nitric Oxide Synthase Type III Novel allele Odds Ratio Polymorphism, Genetic Risk Factors Variable number of tandem repeats (27 bp repeats) White People |
| title | Novel allele of the endothelial nitric oxide synthase gene polymorphism in Caucasian asthmatics |
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