Differentiation and Ig-Allele Switch in Cell Line WEHI-231

Because of its susceptibility to apoptosis upon Ag receptor cross-linking and lack of IgD expression, cells of the mouse cell line WEHI-231 have been classified as immature B cells. In this study we show that early freezings of the WEHI-231 line express IgD but not CD93, which classifies the cells a...

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Veröffentlicht in:	The Journal of immunology (1950) 2007-11, Vol.179 (10), p.6395-6402
Hauptverfasser:	Spillmann, Freia J. X, Beck-Engeser, Gabriele, Wabl, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Antigens - immunology Antigens, Differentiation - immunology Antigens, Differentiation - metabolism Apoptosis - genetics Apoptosis - immunology B-Lymphocytes - enzymology B-Lymphocytes - immunology Cell Line Cell Membrane - genetics Cell Membrane - immunology Cell Membrane - metabolism Cytidine Deaminase - biosynthesis Cytidine Deaminase - genetics Cytidine Deaminase - immunology Enzyme Activation - genetics Enzyme Activation - immunology Female Gene Expression Regulation, Enzymologic - immunology Germinal Center - enzymology Germinal Center - immunology Humans Immunoglobulin D - biosynthesis Immunoglobulin D - genetics Immunoglobulin D - immunology Immunoglobulin M - biosynthesis Immunoglobulin M - genetics Immunoglobulin M - immunology Lymphoma, Mantle-Cell - enzymology Lymphoma, Mantle-Cell - genetics Lymphoma, Mantle-Cell - immunology Male Mice Mice, Inbred BALB C Receptors, Antigen, B-Cell - genetics Receptors, Antigen, B-Cell - immunology Receptors, Antigen, B-Cell - metabolism Somatic Hypermutation, Immunoglobulin - genetics Somatic Hypermutation, Immunoglobulin - immunology
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