The cardiopulmonary effects of dobutamine and norepinephrine in isoflurane-anesthetized foals
To evaluate the cardiovascular effects of norepinephrine (NE) and dobutamine (DB) in isoflurane-anesthetized foals. Prospective laboratory study. Norepinephrine (0.05, 0.10, 0.20, and 0.40 μg kg−1 minute−1) and dobutamine (2.5, 5.0, and 10 μg kg−1 minute−1) were alternately administered to seven hea...
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| Veröffentlicht in: | Veterinary anaesthesia and analgesia 2007-11, Vol.34 (6), p.377-387 |
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| creator | Craig, Cary A Haskins, Steve C Hildebrand, Susan V |
| description | To evaluate the cardiovascular effects of norepinephrine (NE) and dobutamine (DB) in isoflurane-anesthetized foals.
Prospective laboratory study.
Norepinephrine (0.05, 0.10, 0.20, and 0.40 μg kg−1 minute−1) and dobutamine (2.5, 5.0, and 10 μg kg−1 minute−1) were alternately administered to seven healthy, 1- to 2-week-old isoflurane-anesthetized foals. Arterial and pulmonary arterial blood pressure, right atrial pressure, pulmonary artery occlusion pressure, heart rate, body temperature, cardiac output, arterial and mixed venous blood pH, partial pressure of carbon dioxide, partial pressure of oxygen [arterial partial pressure of oxygen (PaO2) and mixed venous partial pressure of oxygen (P v¯O2)], and packed cell volume were measured. Standard base excess, bicarbonate concentration, systemic and pulmonary vascular resistance, cardiac index (CI), stroke volume, left and right stroke work indices, oxygen delivery ( D˙O2), consumption, and extraction were calculated.
Norepinephrine infusion resulted in significant increases in arterial and pulmonary arterial pressure, systemic and pulmonary vascular resistance indices, and PaO2; heart rate was decreased. Dobutamine infusion resulted in significant increases in heart rate, stroke volume index, CI, and arterial and pulmonary arterial blood pressure. Systemic and pulmonary vascular resistance indices were decreased while the ventricular stroke work indices increased. The PaO2 decreased while D˙O2 and oxygen consumption increased. Oxygen extraction decreased and P v¯O2 increased.
Norepinephrine primarily augments arterial blood pressure while decreasing CI. Dobutamine primarily augments CI with only modest increases in arterial blood pressure. Both NE and DB could be useful in the hemodynamic management of anesthetized foals. |
| doi_str_mv | 10.1111/j.1467-2995.2006.00304.x |
| format | Article |
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Prospective laboratory study.
Norepinephrine (0.05, 0.10, 0.20, and 0.40 μg kg−1 minute−1) and dobutamine (2.5, 5.0, and 10 μg kg−1 minute−1) were alternately administered to seven healthy, 1- to 2-week-old isoflurane-anesthetized foals. Arterial and pulmonary arterial blood pressure, right atrial pressure, pulmonary artery occlusion pressure, heart rate, body temperature, cardiac output, arterial and mixed venous blood pH, partial pressure of carbon dioxide, partial pressure of oxygen [arterial partial pressure of oxygen (PaO2) and mixed venous partial pressure of oxygen (P v¯O2)], and packed cell volume were measured. Standard base excess, bicarbonate concentration, systemic and pulmonary vascular resistance, cardiac index (CI), stroke volume, left and right stroke work indices, oxygen delivery ( D˙O2), consumption, and extraction were calculated.
Norepinephrine infusion resulted in significant increases in arterial and pulmonary arterial pressure, systemic and pulmonary vascular resistance indices, and PaO2; heart rate was decreased. Dobutamine infusion resulted in significant increases in heart rate, stroke volume index, CI, and arterial and pulmonary arterial blood pressure. Systemic and pulmonary vascular resistance indices were decreased while the ventricular stroke work indices increased. The PaO2 decreased while D˙O2 and oxygen consumption increased. Oxygen extraction decreased and P v¯O2 increased.
Norepinephrine primarily augments arterial blood pressure while decreasing CI. Dobutamine primarily augments CI with only modest increases in arterial blood pressure. Both NE and DB could be useful in the hemodynamic management of anesthetized foals.</description><identifier>ISSN: 1467-2987</identifier><identifier>EISSN: 1467-2995</identifier><identifier>DOI: 10.1111/j.1467-2995.2006.00304.x</identifier><identifier>PMID: 17696976</identifier><language>eng</language><publisher>Oxford, UK: Elsevier Ltd</publisher><subject><![CDATA[acute effects ; Adrenergic alpha-Agonists - administration & dosage ; Adrenergic alpha-Agonists - pharmacology ; Adrenergic beta-Agonists - administration & dosage ; Adrenergic beta-Agonists - pharmacology ; anesthesia ; Anesthesia - veterinary ; Anesthetics, Inhalation - administration & dosage ; Animals ; Animals, Newborn - physiology ; blood pressure ; Blood Pressure - drug effects ; Carbon Dioxide - blood ; cardiac output ; Cardiac Output - drug effects ; cardiovascular system ; dobutamine ; Dobutamine - administration & dosage ; Dobutamine - pharmacology ; drug evaluation ; Female ; foals ; Horses - physiology ; Hydrogen-Ion Concentration ; Infusions, Intravenous - veterinary ; isoflurane ; Isoflurane - administration & dosage ; Male ; mean arterial pressure ; norepinephrine ; Norepinephrine - administration & dosage ; Norepinephrine - pharmacology ; Oxygen - blood ; Prospective Studies ; Pulmonary Wedge Pressure - drug effects ; sympathomimetics ; veterinary drugs]]></subject><ispartof>Veterinary anaesthesia and analgesia, 2007-11, Vol.34 (6), p.377-387</ispartof><rights>2007 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4874-ef52b8293defabcf7f2fc063f922e2bb8a10db78b2d057b3a5edb01d9302ef233</citedby><cites>FETCH-LOGICAL-c4874-ef52b8293defabcf7f2fc063f922e2bb8a10db78b2d057b3a5edb01d9302ef233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1467-2995.2006.00304.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1467-2995.2006.00304.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17696976$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Craig, Cary A</creatorcontrib><creatorcontrib>Haskins, Steve C</creatorcontrib><creatorcontrib>Hildebrand, Susan V</creatorcontrib><title>The cardiopulmonary effects of dobutamine and norepinephrine in isoflurane-anesthetized foals</title><title>Veterinary anaesthesia and analgesia</title><addtitle>Vet Anaesth Analg</addtitle><description>To evaluate the cardiovascular effects of norepinephrine (NE) and dobutamine (DB) in isoflurane-anesthetized foals.
Prospective laboratory study.
Norepinephrine (0.05, 0.10, 0.20, and 0.40 μg kg−1 minute−1) and dobutamine (2.5, 5.0, and 10 μg kg−1 minute−1) were alternately administered to seven healthy, 1- to 2-week-old isoflurane-anesthetized foals. Arterial and pulmonary arterial blood pressure, right atrial pressure, pulmonary artery occlusion pressure, heart rate, body temperature, cardiac output, arterial and mixed venous blood pH, partial pressure of carbon dioxide, partial pressure of oxygen [arterial partial pressure of oxygen (PaO2) and mixed venous partial pressure of oxygen (P v¯O2)], and packed cell volume were measured. Standard base excess, bicarbonate concentration, systemic and pulmonary vascular resistance, cardiac index (CI), stroke volume, left and right stroke work indices, oxygen delivery ( D˙O2), consumption, and extraction were calculated.
Norepinephrine infusion resulted in significant increases in arterial and pulmonary arterial pressure, systemic and pulmonary vascular resistance indices, and PaO2; heart rate was decreased. Dobutamine infusion resulted in significant increases in heart rate, stroke volume index, CI, and arterial and pulmonary arterial blood pressure. Systemic and pulmonary vascular resistance indices were decreased while the ventricular stroke work indices increased. The PaO2 decreased while D˙O2 and oxygen consumption increased. Oxygen extraction decreased and P v¯O2 increased.
Norepinephrine primarily augments arterial blood pressure while decreasing CI. Dobutamine primarily augments CI with only modest increases in arterial blood pressure. Both NE and DB could be useful in the hemodynamic management of anesthetized foals.</description><subject>acute effects</subject><subject>Adrenergic alpha-Agonists - administration & dosage</subject><subject>Adrenergic alpha-Agonists - pharmacology</subject><subject>Adrenergic beta-Agonists - administration & dosage</subject><subject>Adrenergic beta-Agonists - pharmacology</subject><subject>anesthesia</subject><subject>Anesthesia - veterinary</subject><subject>Anesthetics, Inhalation - administration & dosage</subject><subject>Animals</subject><subject>Animals, Newborn - physiology</subject><subject>blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Carbon Dioxide - blood</subject><subject>cardiac output</subject><subject>Cardiac Output - drug effects</subject><subject>cardiovascular system</subject><subject>dobutamine</subject><subject>Dobutamine - administration & dosage</subject><subject>Dobutamine - pharmacology</subject><subject>drug evaluation</subject><subject>Female</subject><subject>foals</subject><subject>Horses - physiology</subject><subject>Hydrogen-Ion Concentration</subject><subject>Infusions, Intravenous - veterinary</subject><subject>isoflurane</subject><subject>Isoflurane - administration & dosage</subject><subject>Male</subject><subject>mean arterial pressure</subject><subject>norepinephrine</subject><subject>Norepinephrine - administration & dosage</subject><subject>Norepinephrine - pharmacology</subject><subject>Oxygen - blood</subject><subject>Prospective Studies</subject><subject>Pulmonary Wedge Pressure - drug effects</subject><subject>sympathomimetics</subject><subject>veterinary drugs</subject><issn>1467-2987</issn><issn>1467-2995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUU1v1DAQjRCIfsBfgJy4JTh2EicSl6XAFqmCQ7-4oJEdj1kvSZzaCd3y63Ga1XIES9aM7fdm5j1HUZyRNAvr7TbN8pIntK6LlBJSpoQwkqe7J9Hx4eHpIa_4UXTi_ZaQjNcFeR4dZbysy5qXx9H3qw3GjXDK2GFqO9sL9xCj1tiMPrY6VlZOo-hMj7HoVdxbh0M4DBs3X5k-Nt7qdnKixyRsP25wNL9RxdqK1r-InukQ8OU-nkbXnz5enZ0nF1_Xn89WF0mTVzxPUBdUVrRmCrWQjeaa6oaUTNeUIpWyEhlRkleSKlJwyUSBSpJM1YxQ1JSx0-jNUndw9m4KU0BnfINtG0ayk4eyyjmrSRWA1QJsnPXeoYbBmS5ohozAbC1sYXYNZgdhthYerYVdoL7a95hkh-ovce9lALxbAPemxYf_Lgw3q1VIAj1Z6MaPuDvQhfsJJWe8gNsva7g5_7YuPtxewizl9YLXwoL44YyH60tKMkZIRUn5KPb9gsBg_S-DDnxjsG9QGRf-F5Q1_5b9Byoqt7w</recordid><startdate>200711</startdate><enddate>200711</enddate><creator>Craig, Cary A</creator><creator>Haskins, Steve C</creator><creator>Hildebrand, Susan V</creator><general>Elsevier Ltd</general><general>Oxford, UK : Blackwell Publishing Ltd</general><general>Blackwell Publishing Ltd</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200711</creationdate><title>The cardiopulmonary effects of dobutamine and norepinephrine in isoflurane-anesthetized foals</title><author>Craig, Cary A ; Haskins, Steve C ; Hildebrand, Susan V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4874-ef52b8293defabcf7f2fc063f922e2bb8a10db78b2d057b3a5edb01d9302ef233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>acute effects</topic><topic>Adrenergic alpha-Agonists - administration & dosage</topic><topic>Adrenergic alpha-Agonists - pharmacology</topic><topic>Adrenergic beta-Agonists - administration & dosage</topic><topic>Adrenergic beta-Agonists - pharmacology</topic><topic>anesthesia</topic><topic>Anesthesia - veterinary</topic><topic>Anesthetics, Inhalation - administration & dosage</topic><topic>Animals</topic><topic>Animals, Newborn - physiology</topic><topic>blood pressure</topic><topic>Blood Pressure - drug effects</topic><topic>Carbon Dioxide - blood</topic><topic>cardiac output</topic><topic>Cardiac Output - drug effects</topic><topic>cardiovascular system</topic><topic>dobutamine</topic><topic>Dobutamine - administration & dosage</topic><topic>Dobutamine - pharmacology</topic><topic>drug evaluation</topic><topic>Female</topic><topic>foals</topic><topic>Horses - physiology</topic><topic>Hydrogen-Ion Concentration</topic><topic>Infusions, Intravenous - veterinary</topic><topic>isoflurane</topic><topic>Isoflurane - administration & dosage</topic><topic>Male</topic><topic>mean arterial pressure</topic><topic>norepinephrine</topic><topic>Norepinephrine - administration & dosage</topic><topic>Norepinephrine - pharmacology</topic><topic>Oxygen - blood</topic><topic>Prospective Studies</topic><topic>Pulmonary Wedge Pressure - drug effects</topic><topic>sympathomimetics</topic><topic>veterinary drugs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Craig, Cary A</creatorcontrib><creatorcontrib>Haskins, Steve C</creatorcontrib><creatorcontrib>Hildebrand, Susan V</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary anaesthesia and analgesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Craig, Cary A</au><au>Haskins, Steve C</au><au>Hildebrand, Susan V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The cardiopulmonary effects of dobutamine and norepinephrine in isoflurane-anesthetized foals</atitle><jtitle>Veterinary anaesthesia and analgesia</jtitle><addtitle>Vet Anaesth Analg</addtitle><date>2007-11</date><risdate>2007</risdate><volume>34</volume><issue>6</issue><spage>377</spage><epage>387</epage><pages>377-387</pages><issn>1467-2987</issn><eissn>1467-2995</eissn><abstract>To evaluate the cardiovascular effects of norepinephrine (NE) and dobutamine (DB) in isoflurane-anesthetized foals.
Prospective laboratory study.
Norepinephrine (0.05, 0.10, 0.20, and 0.40 μg kg−1 minute−1) and dobutamine (2.5, 5.0, and 10 μg kg−1 minute−1) were alternately administered to seven healthy, 1- to 2-week-old isoflurane-anesthetized foals. Arterial and pulmonary arterial blood pressure, right atrial pressure, pulmonary artery occlusion pressure, heart rate, body temperature, cardiac output, arterial and mixed venous blood pH, partial pressure of carbon dioxide, partial pressure of oxygen [arterial partial pressure of oxygen (PaO2) and mixed venous partial pressure of oxygen (P v¯O2)], and packed cell volume were measured. Standard base excess, bicarbonate concentration, systemic and pulmonary vascular resistance, cardiac index (CI), stroke volume, left and right stroke work indices, oxygen delivery ( D˙O2), consumption, and extraction were calculated.
Norepinephrine infusion resulted in significant increases in arterial and pulmonary arterial pressure, systemic and pulmonary vascular resistance indices, and PaO2; heart rate was decreased. Dobutamine infusion resulted in significant increases in heart rate, stroke volume index, CI, and arterial and pulmonary arterial blood pressure. Systemic and pulmonary vascular resistance indices were decreased while the ventricular stroke work indices increased. The PaO2 decreased while D˙O2 and oxygen consumption increased. Oxygen extraction decreased and P v¯O2 increased.
Norepinephrine primarily augments arterial blood pressure while decreasing CI. Dobutamine primarily augments CI with only modest increases in arterial blood pressure. Both NE and DB could be useful in the hemodynamic management of anesthetized foals.</abstract><cop>Oxford, UK</cop><pub>Elsevier Ltd</pub><pmid>17696976</pmid><doi>10.1111/j.1467-2995.2006.00304.x</doi><tpages>11</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | acute effects Adrenergic alpha-Agonists - administration & dosage Adrenergic alpha-Agonists - pharmacology Adrenergic beta-Agonists - administration & dosage Adrenergic beta-Agonists - pharmacology anesthesia Anesthesia - veterinary Anesthetics, Inhalation - administration & dosage Animals Animals, Newborn - physiology blood pressure Blood Pressure - drug effects Carbon Dioxide - blood cardiac output Cardiac Output - drug effects cardiovascular system dobutamine Dobutamine - administration & dosage Dobutamine - pharmacology drug evaluation Female foals Horses - physiology Hydrogen-Ion Concentration Infusions, Intravenous - veterinary isoflurane Isoflurane - administration & dosage Male mean arterial pressure norepinephrine Norepinephrine - administration & dosage Norepinephrine - pharmacology Oxygen - blood Prospective Studies Pulmonary Wedge Pressure - drug effects sympathomimetics veterinary drugs |
| title | The cardiopulmonary effects of dobutamine and norepinephrine in isoflurane-anesthetized foals |
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