Correlation of Intraoperative Parathyroid Hormone Levels With Parathyroid Gland Size
Objectives: To study the relationship of intraoperative intact parathyroid hormone levels (iPTH) with parathyroid adenoma weight and volume in patients with primary hyperparathyroidism. Methods: Retrospective evaluation of consecutive patients undergoing minimally invasive parathyroidectomy with iPT...
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| Veröffentlicht in: | The Laryngoscope 2007-11, Vol.117 (11), p.1957-1960 |
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| container_issue | 11 |
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| container_title | The Laryngoscope |
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| creator | Moretz III, William H. Watts, Tammara L. Virgin Jr, Frank W. Chin, Edward Gourin, Christine G. Terris, David J. |
| description | Objectives: To study the relationship of intraoperative intact parathyroid hormone levels (iPTH) with parathyroid adenoma weight and volume in patients with primary hyperparathyroidism.
Methods: Retrospective evaluation of consecutive patients undergoing minimally invasive parathyroidectomy with iPTH measurement. Data collected include preoperative serum calcium, ionized calcium, and serum parathyroid hormone (PTH) levels, iPTH levels at baseline, 5 minutes, and 10 minutes, and parathyroid adenoma weight. Adenoma volume was calculated using an equation for the volume of a spheroid object.
Results: Thirty patients underwent minimally invasive parathyroidectomy with iPTH measurement for a single parathyroid adenoma between March 2004 and January 2006. There were 8 men and 22 women, with a mean age of 59.3 (range 26–92) years. A significant correlation between preoperative serum calcium and ionized calcium levels and parathyroid adenoma weight was identified (P = .0008 and P = .03, respectively). A significant correlation was also shown between baseline iPTH measurements and parathyroid adenoma volume (P = .03). There was no correlation between baseline iPTH levels and parathyroid adenoma weight. There was a significant correlation between parathyroid adenoma weight and percentage decrease of iPTH levels at 10 minutes compared to baseline (P = .04).
Conclusion: Preoperative serum calcium and baseline iPTH levels may be useful in predicting parathyroid adenoma weight and volume, respectively. Adenoma weight may relate to the percentage decrease of iPTH levels at the 10‐minute postparathyroidectomy interval. |
| doi_str_mv | 10.1097/MLG.0b013e31813c14fc |
| format | Article |
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Methods: Retrospective evaluation of consecutive patients undergoing minimally invasive parathyroidectomy with iPTH measurement. Data collected include preoperative serum calcium, ionized calcium, and serum parathyroid hormone (PTH) levels, iPTH levels at baseline, 5 minutes, and 10 minutes, and parathyroid adenoma weight. Adenoma volume was calculated using an equation for the volume of a spheroid object.
Results: Thirty patients underwent minimally invasive parathyroidectomy with iPTH measurement for a single parathyroid adenoma between March 2004 and January 2006. There were 8 men and 22 women, with a mean age of 59.3 (range 26–92) years. A significant correlation between preoperative serum calcium and ionized calcium levels and parathyroid adenoma weight was identified (P = .0008 and P = .03, respectively). A significant correlation was also shown between baseline iPTH measurements and parathyroid adenoma volume (P = .03). There was no correlation between baseline iPTH levels and parathyroid adenoma weight. There was a significant correlation between parathyroid adenoma weight and percentage decrease of iPTH levels at 10 minutes compared to baseline (P = .04).
Conclusion: Preoperative serum calcium and baseline iPTH levels may be useful in predicting parathyroid adenoma weight and volume, respectively. Adenoma weight may relate to the percentage decrease of iPTH levels at the 10‐minute postparathyroidectomy interval.</description><identifier>ISSN: 0023-852X</identifier><identifier>EISSN: 1531-4995</identifier><identifier>DOI: 10.1097/MLG.0b013e31813c14fc</identifier><identifier>PMID: 17891053</identifier><identifier>CODEN: LARYA8</identifier><language>eng</language><publisher>Hoboken, NJ: John Wiley & Sons, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Calcium - blood ; Endocrinopathies ; Humans ; hypercalcemia ; Hyperparathyroidism, Primary - blood ; Hyperparathyroidism, Primary - surgery ; intraoperative parathyroid hormone ; Medical sciences ; Middle Aged ; Minimally Invasive Surgical Procedures ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Otorhinolaryngology. Stomatology ; Parathyroid adenoma ; parathyroid gland size ; Parathyroid Glands - pathology ; parathyroid hormone ; Parathyroid Hormone - blood ; Parathyroidectomy - methods ; Parathyroids. Parafollicular cells. Cholecalciferol. Phosphocalcic homeostasis (diseases) ; Retrospective Studies</subject><ispartof>The Laryngoscope, 2007-11, Vol.117 (11), p.1957-1960</ispartof><rights>Copyright © 2007 The Triological Society</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4303-e03fd89d10a81c2496e88429400b175f2013721347454ba1c13430c45fc169733</citedby><cites>FETCH-LOGICAL-c4303-e03fd89d10a81c2496e88429400b175f2013721347454ba1c13430c45fc169733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1097%2FMLG.0b013e31813c14fc$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1097%2FMLG.0b013e31813c14fc$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19228832$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17891053$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moretz III, William H.</creatorcontrib><creatorcontrib>Watts, Tammara L.</creatorcontrib><creatorcontrib>Virgin Jr, Frank W.</creatorcontrib><creatorcontrib>Chin, Edward</creatorcontrib><creatorcontrib>Gourin, Christine G.</creatorcontrib><creatorcontrib>Terris, David J.</creatorcontrib><title>Correlation of Intraoperative Parathyroid Hormone Levels With Parathyroid Gland Size</title><title>The Laryngoscope</title><addtitle>The Laryngoscope</addtitle><description>Objectives: To study the relationship of intraoperative intact parathyroid hormone levels (iPTH) with parathyroid adenoma weight and volume in patients with primary hyperparathyroidism.
Methods: Retrospective evaluation of consecutive patients undergoing minimally invasive parathyroidectomy with iPTH measurement. Data collected include preoperative serum calcium, ionized calcium, and serum parathyroid hormone (PTH) levels, iPTH levels at baseline, 5 minutes, and 10 minutes, and parathyroid adenoma weight. Adenoma volume was calculated using an equation for the volume of a spheroid object.
Results: Thirty patients underwent minimally invasive parathyroidectomy with iPTH measurement for a single parathyroid adenoma between March 2004 and January 2006. There were 8 men and 22 women, with a mean age of 59.3 (range 26–92) years. A significant correlation between preoperative serum calcium and ionized calcium levels and parathyroid adenoma weight was identified (P = .0008 and P = .03, respectively). A significant correlation was also shown between baseline iPTH measurements and parathyroid adenoma volume (P = .03). There was no correlation between baseline iPTH levels and parathyroid adenoma weight. There was a significant correlation between parathyroid adenoma weight and percentage decrease of iPTH levels at 10 minutes compared to baseline (P = .04).
Conclusion: Preoperative serum calcium and baseline iPTH levels may be useful in predicting parathyroid adenoma weight and volume, respectively. Adenoma weight may relate to the percentage decrease of iPTH levels at the 10‐minute postparathyroidectomy interval.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Calcium - blood</subject><subject>Endocrinopathies</subject><subject>Humans</subject><subject>hypercalcemia</subject><subject>Hyperparathyroidism, Primary - blood</subject><subject>Hyperparathyroidism, Primary - surgery</subject><subject>intraoperative parathyroid hormone</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Minimally Invasive Surgical Procedures</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Parathyroid adenoma</subject><subject>parathyroid gland size</subject><subject>Parathyroid Glands - pathology</subject><subject>parathyroid hormone</subject><subject>Parathyroid Hormone - blood</subject><subject>Parathyroidectomy - methods</subject><subject>Parathyroids. Parafollicular cells. Cholecalciferol. Phosphocalcic homeostasis (diseases)</subject><subject>Retrospective Studies</subject><issn>0023-852X</issn><issn>1531-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1vEzEQhi1ERUPpP0BoL3Db1uOP2L5RRbCptC0VbVU4WY53VjVs1qm9KYRfz0aJqODEaUYzz7wz8xLyGugJUKNOL-rqhC4ocOSggXsQrX9GJiA5lMIY-ZxMKGW81JJ9OSQvc_5GKSgu6QtyCEoboJJPyM0spoSdG0Lsi9gW5_2QXFxhGiuPWFy5MbnfpBiaYh7TMvZY1PiIXS7uwnD_V7_qXN8U1-EXviIHresyHu_jEbn9-OFmNi_rT9X57KwuveCUl0h522jTAHUaPBNmiloLZgSlC1CyZeNzigEXSkixcODHlFMvZOthahTnR-TdTneV4sMa82CXIXvsxkMwrrOdaqGYkVtQ7ECfYs4JW7tKYenSxgK1Wzft6Kb9181x7M1ef71YYvM0tLdvBN7uAZe969rkeh_yE2cY05qzkXu_436EDjf_tdzWZ5-_SikAFABsV5U7iZAH_PlHwqXvdqq4kvbusrI1o9cX1fzKXvLf9FmfNw</recordid><startdate>200711</startdate><enddate>200711</enddate><creator>Moretz III, William H.</creator><creator>Watts, Tammara L.</creator><creator>Virgin Jr, Frank W.</creator><creator>Chin, Edward</creator><creator>Gourin, Christine G.</creator><creator>Terris, David J.</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>200711</creationdate><title>Correlation of Intraoperative Parathyroid Hormone Levels With Parathyroid Gland Size</title><author>Moretz III, William H. ; Watts, Tammara L. ; Virgin Jr, Frank W. ; Chin, Edward ; Gourin, Christine G. ; Terris, David J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4303-e03fd89d10a81c2496e88429400b175f2013721347454ba1c13430c45fc169733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Calcium - blood</topic><topic>Endocrinopathies</topic><topic>Humans</topic><topic>hypercalcemia</topic><topic>Hyperparathyroidism, Primary - blood</topic><topic>Hyperparathyroidism, Primary - surgery</topic><topic>intraoperative parathyroid hormone</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Minimally Invasive Surgical Procedures</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Parathyroid adenoma</topic><topic>parathyroid gland size</topic><topic>Parathyroid Glands - pathology</topic><topic>parathyroid hormone</topic><topic>Parathyroid Hormone - blood</topic><topic>Parathyroidectomy - methods</topic><topic>Parathyroids. Parafollicular cells. Cholecalciferol. Phosphocalcic homeostasis (diseases)</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moretz III, William H.</creatorcontrib><creatorcontrib>Watts, Tammara L.</creatorcontrib><creatorcontrib>Virgin Jr, Frank W.</creatorcontrib><creatorcontrib>Chin, Edward</creatorcontrib><creatorcontrib>Gourin, Christine G.</creatorcontrib><creatorcontrib>Terris, David J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>The Laryngoscope</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moretz III, William H.</au><au>Watts, Tammara L.</au><au>Virgin Jr, Frank W.</au><au>Chin, Edward</au><au>Gourin, Christine G.</au><au>Terris, David J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation of Intraoperative Parathyroid Hormone Levels With Parathyroid Gland Size</atitle><jtitle>The Laryngoscope</jtitle><addtitle>The Laryngoscope</addtitle><date>2007-11</date><risdate>2007</risdate><volume>117</volume><issue>11</issue><spage>1957</spage><epage>1960</epage><pages>1957-1960</pages><issn>0023-852X</issn><eissn>1531-4995</eissn><coden>LARYA8</coden><abstract>Objectives: To study the relationship of intraoperative intact parathyroid hormone levels (iPTH) with parathyroid adenoma weight and volume in patients with primary hyperparathyroidism.
Methods: Retrospective evaluation of consecutive patients undergoing minimally invasive parathyroidectomy with iPTH measurement. Data collected include preoperative serum calcium, ionized calcium, and serum parathyroid hormone (PTH) levels, iPTH levels at baseline, 5 minutes, and 10 minutes, and parathyroid adenoma weight. Adenoma volume was calculated using an equation for the volume of a spheroid object.
Results: Thirty patients underwent minimally invasive parathyroidectomy with iPTH measurement for a single parathyroid adenoma between March 2004 and January 2006. There were 8 men and 22 women, with a mean age of 59.3 (range 26–92) years. A significant correlation between preoperative serum calcium and ionized calcium levels and parathyroid adenoma weight was identified (P = .0008 and P = .03, respectively). A significant correlation was also shown between baseline iPTH measurements and parathyroid adenoma volume (P = .03). There was no correlation between baseline iPTH levels and parathyroid adenoma weight. There was a significant correlation between parathyroid adenoma weight and percentage decrease of iPTH levels at 10 minutes compared to baseline (P = .04).
Conclusion: Preoperative serum calcium and baseline iPTH levels may be useful in predicting parathyroid adenoma weight and volume, respectively. Adenoma weight may relate to the percentage decrease of iPTH levels at the 10‐minute postparathyroidectomy interval.</abstract><cop>Hoboken, NJ</cop><pub>John Wiley & Sons, Inc</pub><pmid>17891053</pmid><doi>10.1097/MLG.0b013e31813c14fc</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Calcium - blood Endocrinopathies Humans hypercalcemia Hyperparathyroidism, Primary - blood Hyperparathyroidism, Primary - surgery intraoperative parathyroid hormone Medical sciences Middle Aged Minimally Invasive Surgical Procedures Non tumoral diseases. Target tissue resistance. Benign neoplasms Otorhinolaryngology. Stomatology Parathyroid adenoma parathyroid gland size Parathyroid Glands - pathology parathyroid hormone Parathyroid Hormone - blood Parathyroidectomy - methods Parathyroids. Parafollicular cells. Cholecalciferol. Phosphocalcic homeostasis (diseases) Retrospective Studies |
| title | Correlation of Intraoperative Parathyroid Hormone Levels With Parathyroid Gland Size |
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