Role of cytochrome P450 metabolites of arachidonic acid in regulation of corporal smooth muscle tone in diabetic and older rats

Abstract This study examined the role of cytochrome P450 (CYP) metabolites of arachidonic acid (AA) to rat corporal smooth muscle tone. 11, 12-Epoxyeicosatrienoic acid (EET) (10 − 11 –10 − 6 M) produced dose-dependent relaxation of rat (control; 10 weeks old) corpus cavernosum with a pD2 value of 8...

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Veröffentlicht in:	Vascular pharmacology 2007-11, Vol.47 (5), p.281-287
Hauptverfasser:	Yousif, Mariam H.M, Benter, Ibrahim F
Format:	Artikel
Sprache:	eng
Schlagworte:	20-HETE 8,11,14-Eicosatrienoic Acid - analogs & derivatives 8,11,14-Eicosatrienoic Acid - metabolism 8,11,14-Eicosatrienoic Acid - pharmacology Aging - metabolism Animals Arachidonic Acid - metabolism Arachidonic Acid - pharmacology Cardiovascular Cytochrome P-450 Enzyme System - metabolism Diabetes Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - physiopathology Dose-Response Relationship, Drug Epoxyeicosatrienoic acid Erectile dysfunction Hydroxyeicosatetraenoic Acids - metabolism Hydroxyeicosatetraenoic Acids - pharmacology In Vitro Techniques KATP Channels - physiology Large-Conductance Calcium-Activated Potassium Channels - physiology Male Muscle Contraction - drug effects Muscle Relaxation - drug effects Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - physiopathology Penis - drug effects Penis - metabolism Penis - physiopathology Rats Rats, Wistar
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