Molecular and Cellular Mechanisms of Syndecans in Tissue Injury and Inflammation
The syndecan family of heparan sulfate protecoglycans is expressed on the surface of all adherent cells. Syndecans interact with a wide variety of molecules, including growth factors, cytokines, proteinases, adhesion receptors and extracellular matrix components, through their heparan sulfate chains...
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| Veröffentlicht in: | Molecules and cells 2007-10, Vol.24 (2), p.153-166 |
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| container_title | Molecules and cells |
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| creator | Bartlett, Allison H. (Baylor College of Medicine, Houston, TX, USA) Hayashida, Kazutaka (Baylor College of Medicine, Houston, TX, USA) Park, P.W. (Baylor College of Medicine, Houston, TX, USA), E-mail: pyong.park@childrens.harvard.edu |
| description | The syndecan family of heparan sulfate protecoglycans is expressed on the surface of all adherent cells. Syndecans interact with a wide variety of molecules, including growth factors, cytokines, proteinases, adhesion receptors and extracellular matrix components, through their heparan sulfate chains. Recent studies indicate that these interactions not only regulate key events in development and homeostasis, but also key mechanisms of the host inflammatory response. This review will focus on the molecular and cellular aspects of how syndecans modulate tissue injury and inflammation, and how syndecans affect the outcome of inflammatory diseases in vivo. |
| doi_str_mv | 10.1016/s1016-8478(23)07324-7 |
| format | Article |
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This review will focus on the molecular and cellular aspects of how syndecans modulate tissue injury and inflammation, and how syndecans affect the outcome of inflammatory diseases in vivo.</description><subject>Animals</subject><subject>chemokine</subject><subject>heparan sulfate</subject><subject>Heparan Sulfate Proteoglycans - biosynthesis</subject><subject>Heparan Sulfate Proteoglycans - chemistry</subject><subject>Host Defense</subject><subject>Humans</subject><subject>INFECCION</subject><subject>INFECTION</subject><subject>Infections - metabolism</subject><subject>Inflammation - metabolism</subject><subject>microbial pathogenesis</subject><subject>NEUMONIA</subject><subject>PNEUMONIA</subject><subject>PNEUMONIE</subject><subject>Protein Structure, Tertiary</subject><subject>PROTEOGLICANOS</subject><subject>PROTEOGLYCANE</subject><subject>PROTEOGLYCANS</subject><subject>Syndecans - metabolism</subject><subject>tissue repair</subject><issn>1016-8478</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMtOwzAQRb0A0VL4hKKsECwC49iOnSWqeFS0AtGytlw_IFXiFLtZ9O9J0wo2M5rRvfM4CI0x3GHA-X3cx1RQLm4ycgucZDTlJ2j41x6g8xjXAJjnmThDA8wLLljOh-h93lRWt5UKifImmdiq6ou51d_Kl7GOSeOSxc4bq5WPSemTZRlja5OpX7dh17um3lWqrtW2bPwFOnWqivbymEfo8-lxOXlJZ2_P08nDLNWUZttUg1JGU8scdYRwAcIWgIkByixfObCaAeNgMOGqKLBRwhqxKiDXhFHlgIzQ9WHuJjQ_rY1bWZdRd-crb5s2yrz7G-eQd0J2EOrQxBisk5tQ1irsJAa5JyQXfdxzkhmRPT7JO9_VcUG7qq35dx3ZdYLxQeBUI9VXKKN8_cgABEBGMSO_pkV2Pg</recordid><startdate>20071031</startdate><enddate>20071031</enddate><creator>Bartlett, Allison H. 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| source | MEDLINE; SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Animals chemokine heparan sulfate Heparan Sulfate Proteoglycans - biosynthesis Heparan Sulfate Proteoglycans - chemistry Host Defense Humans INFECCION INFECTION Infections - metabolism Inflammation - metabolism microbial pathogenesis NEUMONIA PNEUMONIA PNEUMONIE Protein Structure, Tertiary PROTEOGLICANOS PROTEOGLYCANE PROTEOGLYCANS Syndecans - metabolism tissue repair |
| title | Molecular and Cellular Mechanisms of Syndecans in Tissue Injury and Inflammation |
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