Developmental Stage-Dependent Collaboration between the TNF Receptor-Associated Factor 6 and Lymphotoxin Pathways for B Cell Follicle Organization in Secondary Lymphoid Organs

Signal transduction pathways regulating NF-kappaB activation essential for microenvironment formation in secondary lymphoid organs remain to be determined. We investigated the effect of a deficiency of TNFR-associated factor 6 (TRAF6), which activates the classical NF-kappaB pathway, in splenic micr...

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Veröffentlicht in:	The Journal of immunology (1950) 2007-11, Vol.179 (10), p.6799-6807
Hauptverfasser:	Qin, Junwen, Konno, Hiroyasu, Ohshima, Daisuke, Yanai, Hiromi, Motegi, Hidehiko, Shimo, Yusuke, Hirota, Fumiko, Matsumoto, Mitsuru, Takaki, Satoshi, Inoue, Jun-ichiro, Akiyama, Taishin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Differentiation - biosynthesis Antigens, Differentiation - immunology Cell Differentiation Chemokine CXCL13 - biosynthesis Chemokine CXCL13 - immunology Dendritic Cells, Follicular - immunology Dendritic Cells, Follicular - metabolism Liver - growth & development Liver - immunology Liver - metabolism Lymphotoxin beta Receptor - genetics Lymphotoxin beta Receptor - immunology Lymphotoxin beta Receptor - metabolism Lymphotoxin-beta - biosynthesis Lymphotoxin-beta - genetics Lymphotoxin-beta - immunology Mice Mice, Inbred BALB C Mice, Knockout Mice, Mutant Strains NF-kappa B - genetics NF-kappa B - immunology NF-kappa B - metabolism Signal Transduction - genetics Signal Transduction - immunology Spleen - growth & development Spleen - immunology Spleen - metabolism TNF Receptor-Associated Factor 6 - genetics TNF Receptor-Associated Factor 6 - immunology TNF Receptor-Associated Factor 6 - metabolism
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