Adenosine induces expression of glial cell line-derived neurotrophic factor (GDNF) in primary rat astrocytes

Adenosine, which accumulates rapidly during ischemia due to the breakdown of ATP, has beneficial effects in many tissues. We examined whether adenosine induces the production of glial cell line-derived neurotrophic factor (GDNF) in cultured astrocytes. We evaluated GDNF mRNA expression and GDNF prod...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience research 2007-12, Vol.59 (4), p.467-474
Hauptverfasser:	Yamagata, Kazuo, Hakata, Kumiko, Maeda, Aya, Mochizuki, Chiemi, Matsufuji, Hiroshi, Chino, Makoto, Yamori, Yukio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Adenosine - analogs & derivatives Adenosine - metabolism Adenosine - pharmacology Adenosine A2 Receptor Agonists Adenosine A2 Receptor Antagonists Animals Antihypertensive Agents - pharmacology Astrocytes Astrocytes - drug effects Astrocytes - metabolism Astrocytes - secretion Cells, Cultured Central Nervous System - drug effects Central Nervous System - metabolism Down-Regulation - drug effects Down-Regulation - physiology Flavins - pharmacology GDNF Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Glial Cell Line-Derived Neurotrophic Factor - genetics Glial Cell Line-Derived Neurotrophic Factor - metabolism Glial Cell Line-Derived Neurotrophic Factor - secretion Phenethylamines - pharmacology Rats Rats, Inbred SHR Rats, Inbred WKY Receptor, Adenosine A2B - metabolism RNA, Messenger - drug effects RNA, Messenger - metabolism SHRSP Species Specificity Stroke
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!