The combined use of brachial artery flow-mediated dilatation and carotid artery intima-media thickness measurements may be a method to determine vasculogenic erectile dysfunction
The aim of this study was to investigate the relationship between penile color Doppler sonography (CDS) findings and sonographic endothelial parameters in patients with erectile dysfunction (ED), including intima-media thickness (IMT) of common carotid arteries (CCA) and flow-mediated dilatation (FM...
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| Veröffentlicht in: | International journal of impotence research 2007-11, Vol.19 (6), p.577-583 |
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| creator | Ucar, G Secil, M Demir, O Demir, T Comlekci, A Uysal, S Esen, A A |
| description | The aim of this study was to investigate the relationship between penile color Doppler sonography (CDS) findings and sonographic endothelial parameters in patients with erectile dysfunction (ED), including intima-media thickness (IMT) of common carotid arteries (CCA) and flow-mediated dilatation (FMD) of brachial artery. Fifty-six ED patients were included in the study. Penile CDS, IMT of CCA and FMD of brachial artery were performed in all patients. According to penile CDS findings, 27 (48%) patients had non-vasculogenic and 29 (52%) patients had vasculogenic ED. Among 29 patients, 17 (30%) patients had cavernous veno-occlusive disease (CVOD) and 12 (22%) patients had arterial/combined insufficiency (AI). Median (interquartile range) FMD values of non-vasculogenic ED, CVOD and AI were 12.50 (6.54)%, 12.82 (7.41)% and 6.25 (7.17)%, respectively. FMD was found to be impaired significantly in AI group when compared to the other groups. FMD values of CVOD group were lower when compared to non-vasculogenic group, but the difference was not statistically significant. IMT values of vasculogenic ED patients were higher than non-vasculogenic ED patients (
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| doi_str_mv | 10.1038/sj.ijir.3901572 |
| format | Article |
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P
<0.05). Although IMT values were higher in AI group when compared to CVOD, the difference was not statistically significant. The combined use of IMT and FMD established the diagnosis of vasculogenic ED with 100% sensitivity and 59.2% specificity. The positive predictive value was 72%, negative predictive value 100% and accuracy 80%. The combined use of brachial artery FMD and carotid arteries IMT measurements may be suggested as an alternative method to evaluate vasculogenic ED.</description><identifier>ISSN: 0955-9930</identifier><identifier>EISSN: 1476-5489</identifier><identifier>DOI: 10.1038/sj.ijir.3901572</identifier><identifier>PMID: 17568758</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Biological and medical sciences ; Brachial Artery - anatomy & histology ; Brachial Artery - physiology ; Care and treatment ; Carotid arteries ; Carotid Arteries - anatomy & histology ; Diagnosis ; Dilatation ; Erectile dysfunction ; Erectile Dysfunction - diagnosis ; Erectile Dysfunction - diagnostic imaging ; Gynecology. Andrology. Obstetrics ; Humans ; Impotence ; Male ; Male genital diseases ; Medical Laboratory Science - methods ; Medical sciences ; Medicine ; Medicine & Public Health ; Methods ; Middle Aged ; Non tumoral diseases ; original-article ; Penis ; Regional Blood Flow ; Reproductive Medicine ; Risk factors ; rology ; Tunica Intima - anatomy & histology ; Ultrasonography, Doppler ; Ultrasound imaging ; Urology ; Veins & arteries</subject><ispartof>International journal of impotence research, 2007-11, Vol.19 (6), p.577-583</ispartof><rights>Springer Nature Limited 2007</rights><rights>2007 INIST-CNRS</rights><rights>COPYRIGHT 2007 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Nov 2007</rights><rights>Nature Publishing Group 2007.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c560t-5e05f43c19f0a5aaeafc7b54fce7ff5507e1af9c1a5d125683a6b34d851bd0eb3</citedby><cites>FETCH-LOGICAL-c560t-5e05f43c19f0a5aaeafc7b54fce7ff5507e1af9c1a5d125683a6b34d851bd0eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.ijir.3901572$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.ijir.3901572$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19198618$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17568758$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ucar, G</creatorcontrib><creatorcontrib>Secil, M</creatorcontrib><creatorcontrib>Demir, O</creatorcontrib><creatorcontrib>Demir, T</creatorcontrib><creatorcontrib>Comlekci, A</creatorcontrib><creatorcontrib>Uysal, S</creatorcontrib><creatorcontrib>Esen, A A</creatorcontrib><title>The combined use of brachial artery flow-mediated dilatation and carotid artery intima-media thickness measurements may be a method to determine vasculogenic erectile dysfunction</title><title>International journal of impotence research</title><addtitle>Int J Impot Res</addtitle><addtitle>Int J Impot Res</addtitle><description>The aim of this study was to investigate the relationship between penile color Doppler sonography (CDS) findings and sonographic endothelial parameters in patients with erectile dysfunction (ED), including intima-media thickness (IMT) of common carotid arteries (CCA) and flow-mediated dilatation (FMD) of brachial artery. Fifty-six ED patients were included in the study. Penile CDS, IMT of CCA and FMD of brachial artery were performed in all patients. According to penile CDS findings, 27 (48%) patients had non-vasculogenic and 29 (52%) patients had vasculogenic ED. Among 29 patients, 17 (30%) patients had cavernous veno-occlusive disease (CVOD) and 12 (22%) patients had arterial/combined insufficiency (AI). Median (interquartile range) FMD values of non-vasculogenic ED, CVOD and AI were 12.50 (6.54)%, 12.82 (7.41)% and 6.25 (7.17)%, respectively. FMD was found to be impaired significantly in AI group when compared to the other groups. FMD values of CVOD group were lower when compared to non-vasculogenic group, but the difference was not statistically significant. IMT values of vasculogenic ED patients were higher than non-vasculogenic ED patients (
P
<0.05). Although IMT values were higher in AI group when compared to CVOD, the difference was not statistically significant. The combined use of IMT and FMD established the diagnosis of vasculogenic ED with 100% sensitivity and 59.2% specificity. The positive predictive value was 72%, negative predictive value 100% and accuracy 80%. The combined use of brachial artery FMD and carotid arteries IMT measurements may be suggested as an alternative method to evaluate vasculogenic ED.</description><subject>Biological and medical sciences</subject><subject>Brachial Artery - anatomy & histology</subject><subject>Brachial Artery - physiology</subject><subject>Care and treatment</subject><subject>Carotid arteries</subject><subject>Carotid Arteries - anatomy & histology</subject><subject>Diagnosis</subject><subject>Dilatation</subject><subject>Erectile dysfunction</subject><subject>Erectile Dysfunction - diagnosis</subject><subject>Erectile Dysfunction - diagnostic imaging</subject><subject>Gynecology. Andrology. 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Andrology. Obstetrics</topic><topic>Humans</topic><topic>Impotence</topic><topic>Male</topic><topic>Male genital diseases</topic><topic>Medical Laboratory Science - methods</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Methods</topic><topic>Middle Aged</topic><topic>Non tumoral diseases</topic><topic>original-article</topic><topic>Penis</topic><topic>Regional Blood Flow</topic><topic>Reproductive Medicine</topic><topic>Risk factors</topic><topic>rology</topic><topic>Tunica Intima - anatomy & histology</topic><topic>Ultrasonography, Doppler</topic><topic>Ultrasound imaging</topic><topic>Urology</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ucar, G</creatorcontrib><creatorcontrib>Secil, M</creatorcontrib><creatorcontrib>Demir, O</creatorcontrib><creatorcontrib>Demir, T</creatorcontrib><creatorcontrib>Comlekci, A</creatorcontrib><creatorcontrib>Uysal, S</creatorcontrib><creatorcontrib>Esen, A A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of impotence research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ucar, G</au><au>Secil, M</au><au>Demir, O</au><au>Demir, T</au><au>Comlekci, A</au><au>Uysal, S</au><au>Esen, A A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The combined use of brachial artery flow-mediated dilatation and carotid artery intima-media thickness measurements may be a method to determine vasculogenic erectile dysfunction</atitle><jtitle>International journal of impotence research</jtitle><stitle>Int J Impot Res</stitle><addtitle>Int J Impot Res</addtitle><date>2007-11-01</date><risdate>2007</risdate><volume>19</volume><issue>6</issue><spage>577</spage><epage>583</epage><pages>577-583</pages><issn>0955-9930</issn><eissn>1476-5489</eissn><abstract>The aim of this study was to investigate the relationship between penile color Doppler sonography (CDS) findings and sonographic endothelial parameters in patients with erectile dysfunction (ED), including intima-media thickness (IMT) of common carotid arteries (CCA) and flow-mediated dilatation (FMD) of brachial artery. Fifty-six ED patients were included in the study. Penile CDS, IMT of CCA and FMD of brachial artery were performed in all patients. According to penile CDS findings, 27 (48%) patients had non-vasculogenic and 29 (52%) patients had vasculogenic ED. Among 29 patients, 17 (30%) patients had cavernous veno-occlusive disease (CVOD) and 12 (22%) patients had arterial/combined insufficiency (AI). Median (interquartile range) FMD values of non-vasculogenic ED, CVOD and AI were 12.50 (6.54)%, 12.82 (7.41)% and 6.25 (7.17)%, respectively. FMD was found to be impaired significantly in AI group when compared to the other groups. FMD values of CVOD group were lower when compared to non-vasculogenic group, but the difference was not statistically significant. IMT values of vasculogenic ED patients were higher than non-vasculogenic ED patients (
P
<0.05). Although IMT values were higher in AI group when compared to CVOD, the difference was not statistically significant. The combined use of IMT and FMD established the diagnosis of vasculogenic ED with 100% sensitivity and 59.2% specificity. The positive predictive value was 72%, negative predictive value 100% and accuracy 80%. The combined use of brachial artery FMD and carotid arteries IMT measurements may be suggested as an alternative method to evaluate vasculogenic ED.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>17568758</pmid><doi>10.1038/sj.ijir.3901572</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature - Complete Springer Journals |
| subjects | Biological and medical sciences Brachial Artery - anatomy & histology Brachial Artery - physiology Care and treatment Carotid arteries Carotid Arteries - anatomy & histology Diagnosis Dilatation Erectile dysfunction Erectile Dysfunction - diagnosis Erectile Dysfunction - diagnostic imaging Gynecology. Andrology. Obstetrics Humans Impotence Male Male genital diseases Medical Laboratory Science - methods Medical sciences Medicine Medicine & Public Health Methods Middle Aged Non tumoral diseases original-article Penis Regional Blood Flow Reproductive Medicine Risk factors rology Tunica Intima - anatomy & histology Ultrasonography, Doppler Ultrasound imaging Urology Veins & arteries |
| title | The combined use of brachial artery flow-mediated dilatation and carotid artery intima-media thickness measurements may be a method to determine vasculogenic erectile dysfunction |
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