Impairment of hippocampal long‐term depression and defective spatial learning and memory in p35–/– mice

Cdk5 (cyclin‐dependent kinase 5) activity is dependent upon association with one of two neuron‐specific activators, p35 or p39. Genetic deletion of Cdk5 causes perinatal lethality with severe defects in corticogenesis and neuronal positioning. p35–/– mice are viable with milder histological abnormal...

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Veröffentlicht in:	Journal of neurochemistry 2005-08, Vol.94 (4), p.917-925
Hauptverfasser:	Ohshima, Toshio, Ogura, Hiroo, Tomizawa, Kazuhito, Hayashi, Kanehiro, Suzuki, Hiromi, Saito, Taro, Kamei, Hirotsugu, Nishi, Akinori, Bibb, James A., Hisanaga, Shin‐ichi, Matsui, Hideki, Mikoshiba, Katsuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biochemistry Biological and medical sciences Central nervous system Chromosome aberrations Cyclin-Dependent Kinase 5 Cyclin-dependent kinases Cyclin-Dependent Kinases - metabolism Electrophysiology Fundamental and applied biological sciences. Psychology Hippocampus - metabolism Hippocampus - pathology Hippocampus - physiology Hippocampus - physiopathology Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Long-Term Synaptic Depression - physiology long‐term depression long‐term potentiation Maze Learning - physiology Medical genetics Medical sciences Memory - physiology Mental depression Mice Mice, Knockout Neurology Neuronal Plasticity neuron‐specific activators Phosphorylation Phosphotransferases - deficiency Phosphotransferases - physiology Rodents Synapses synaptic plasticity Vertebrates: nervous system and sense organs
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